Short Bowel Syndrome: Intestinal Adaptation and Medical Therapy
Short bowel syndrome is a clinical entity, a consequence of significant loss of intestinal surface area, and manifests a variable picture of diarrhea, steatorrhea, malabsorprion and weight loss. Previously high mortality rates have been reduced by the early use of parenteral nutrition and have subse...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1990-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1990/701014 |
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| _version_ | 1832559815841284096 |
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| author | WD Buie OG Thurston Richard N Fedorak |
| author_facet | WD Buie OG Thurston Richard N Fedorak |
| author_sort | WD Buie |
| collection | DOAJ |
| description | Short bowel syndrome is a clinical entity, a consequence of
significant loss of intestinal surface area, and manifests a variable picture of
diarrhea, steatorrhea, malabsorprion and weight loss. Previously high mortality
rates have been reduced by the early use of parenteral nutrition and have
subsequently resulted in increased survival and prevalence of the condition.
Ultimate patient survival is dependent on the intrinsic adaptive ability of residual
intestine and this, in turn, is dependent upon length, type, functional state and
the presence or absence of an ileocecal valve. The mechanisms of intestinal
adaptation are not entirely understood; however, they can be grouped into three
broad categories: luminal nutrition, hormonal factors, and pancreaticobiliary
secretion. Medical treatment of short bowel syndrome remains supportive and
centres around the control of three pathophysiological defects: decreased intestinal
transit time, gastric hypersecretion, and reduced functional mucosal surface
area. |
| format | Article |
| id | doaj-art-2e16b66593644d8cb012a16db682cb8c |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 1990-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-2e16b66593644d8cb012a16db682cb8c2025-02-03T01:29:06ZengWileyCanadian Journal of Gastroenterology0835-79001990-01-0142707810.1155/1990/701014Short Bowel Syndrome: Intestinal Adaptation and Medical TherapyWD BuieOG ThurstonRichard N FedorakShort bowel syndrome is a clinical entity, a consequence of significant loss of intestinal surface area, and manifests a variable picture of diarrhea, steatorrhea, malabsorprion and weight loss. Previously high mortality rates have been reduced by the early use of parenteral nutrition and have subsequently resulted in increased survival and prevalence of the condition. Ultimate patient survival is dependent on the intrinsic adaptive ability of residual intestine and this, in turn, is dependent upon length, type, functional state and the presence or absence of an ileocecal valve. The mechanisms of intestinal adaptation are not entirely understood; however, they can be grouped into three broad categories: luminal nutrition, hormonal factors, and pancreaticobiliary secretion. Medical treatment of short bowel syndrome remains supportive and centres around the control of three pathophysiological defects: decreased intestinal transit time, gastric hypersecretion, and reduced functional mucosal surface area.http://dx.doi.org/10.1155/1990/701014 |
| spellingShingle | WD Buie OG Thurston Richard N Fedorak Short Bowel Syndrome: Intestinal Adaptation and Medical Therapy Canadian Journal of Gastroenterology |
| title | Short Bowel Syndrome: Intestinal Adaptation and Medical Therapy |
| title_full | Short Bowel Syndrome: Intestinal Adaptation and Medical Therapy |
| title_fullStr | Short Bowel Syndrome: Intestinal Adaptation and Medical Therapy |
| title_full_unstemmed | Short Bowel Syndrome: Intestinal Adaptation and Medical Therapy |
| title_short | Short Bowel Syndrome: Intestinal Adaptation and Medical Therapy |
| title_sort | short bowel syndrome intestinal adaptation and medical therapy |
| url | http://dx.doi.org/10.1155/1990/701014 |
| work_keys_str_mv | AT wdbuie shortbowelsyndromeintestinaladaptationandmedicaltherapy AT ogthurston shortbowelsyndromeintestinaladaptationandmedicaltherapy AT richardnfedorak shortbowelsyndromeintestinaladaptationandmedicaltherapy |