Research Progress in Small-Molecule Detection Using Aptamer-Based SERS Techniques
Nucleic acid aptamers are single-stranded oligonucleotides that are selected through exponential enrichment (SELEX) technology from synthetic DNA/RNA libraries. These aptamers can specifically recognize and bind to target molecules, serving as specific recognition elements. Surface-enhanced Raman sc...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Biosensors |
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| Online Access: | https://www.mdpi.com/2079-6374/15/1/29 |
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| author | Li Zheng Qingdan Ye Mengmeng Wang Fan Sun Qiang Chen Xiaoping Yu Yufeng Wang Pei Liang |
| author_facet | Li Zheng Qingdan Ye Mengmeng Wang Fan Sun Qiang Chen Xiaoping Yu Yufeng Wang Pei Liang |
| author_sort | Li Zheng |
| collection | DOAJ |
| description | Nucleic acid aptamers are single-stranded oligonucleotides that are selected through exponential enrichment (SELEX) technology from synthetic DNA/RNA libraries. These aptamers can specifically recognize and bind to target molecules, serving as specific recognition elements. Surface-enhanced Raman scattering (SERS) spectroscopy is an ultra-sensitive, non-destructive analytical technique that can rapidly acquire the “fingerprint information” of the measured molecules. It has been widely applied in qualitative and trace analysis across various fields, including food safety, environmental monitoring, and biomedical applications. Small molecules, such as toxins, antibiotics, and pesticides, have significant biological effects and are harmful to both human health and the environment. In this paper, we mainly introduced the application and the research progress of SERS detection with aptamers (aptamer-based SERS techniques) in the field of small-molecule detection, particularly in the analysis of pesticide (animal) residues, antibiotics, and toxins. And the progress and prospect of combining the two methods in detection were reviewed. |
| format | Article |
| id | doaj-art-2e0d7c62f8584f5089626544d0c962ab |
| institution | Kabale University |
| issn | 2079-6374 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj-art-2e0d7c62f8584f5089626544d0c962ab2025-01-24T13:25:29ZengMDPI AGBiosensors2079-63742025-01-011512910.3390/bios15010029Research Progress in Small-Molecule Detection Using Aptamer-Based SERS TechniquesLi Zheng0Qingdan Ye1Mengmeng Wang2Fan Sun3Qiang Chen4Xiaoping Yu5Yufeng Wang6Pei Liang7College of Optical and Electronic Technology, China Jiliang University, Hangzhou 310018, ChinaCollege of Optical and Electronic Technology, China Jiliang University, Hangzhou 310018, ChinaCollege of Optical and Electronic Technology, China Jiliang University, Hangzhou 310018, ChinaKey Laboratory of Microbiological Metrology, Measurement & Bio-Product Quality Security, State Administration for Market Regulation, Zhejiang Provincial Key Laboratory of Biometrology and Inspection & Quarantine, College of Life Sciences, China Jiliang University, Hangzhou 310018, ChinaCollege of Metrology and Measurement Engineering, China Jiliang University, Hangzhou 310018, ChinaKey Laboratory of Microbiological Metrology, Measurement & Bio-Product Quality Security, State Administration for Market Regulation, Zhejiang Provincial Key Laboratory of Biometrology and Inspection & Quarantine, College of Life Sciences, China Jiliang University, Hangzhou 310018, ChinaKey Laboratory of Microbiological Metrology, Measurement & Bio-Product Quality Security, State Administration for Market Regulation, Zhejiang Provincial Key Laboratory of Biometrology and Inspection & Quarantine, College of Life Sciences, China Jiliang University, Hangzhou 310018, ChinaCollege of Optical and Electronic Technology, China Jiliang University, Hangzhou 310018, ChinaNucleic acid aptamers are single-stranded oligonucleotides that are selected through exponential enrichment (SELEX) technology from synthetic DNA/RNA libraries. These aptamers can specifically recognize and bind to target molecules, serving as specific recognition elements. Surface-enhanced Raman scattering (SERS) spectroscopy is an ultra-sensitive, non-destructive analytical technique that can rapidly acquire the “fingerprint information” of the measured molecules. It has been widely applied in qualitative and trace analysis across various fields, including food safety, environmental monitoring, and biomedical applications. Small molecules, such as toxins, antibiotics, and pesticides, have significant biological effects and are harmful to both human health and the environment. In this paper, we mainly introduced the application and the research progress of SERS detection with aptamers (aptamer-based SERS techniques) in the field of small-molecule detection, particularly in the analysis of pesticide (animal) residues, antibiotics, and toxins. And the progress and prospect of combining the two methods in detection were reviewed.https://www.mdpi.com/2079-6374/15/1/29small moleculeaptamerSERSsensors |
| spellingShingle | Li Zheng Qingdan Ye Mengmeng Wang Fan Sun Qiang Chen Xiaoping Yu Yufeng Wang Pei Liang Research Progress in Small-Molecule Detection Using Aptamer-Based SERS Techniques Biosensors small molecule aptamer SERS sensors |
| title | Research Progress in Small-Molecule Detection Using Aptamer-Based SERS Techniques |
| title_full | Research Progress in Small-Molecule Detection Using Aptamer-Based SERS Techniques |
| title_fullStr | Research Progress in Small-Molecule Detection Using Aptamer-Based SERS Techniques |
| title_full_unstemmed | Research Progress in Small-Molecule Detection Using Aptamer-Based SERS Techniques |
| title_short | Research Progress in Small-Molecule Detection Using Aptamer-Based SERS Techniques |
| title_sort | research progress in small molecule detection using aptamer based sers techniques |
| topic | small molecule aptamer SERS sensors |
| url | https://www.mdpi.com/2079-6374/15/1/29 |
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