Pituranthos chloranthus Oil as an Antioxidant-Based Adjuvant Therapy against Cisplatin-Induced Nephrotoxicity
The therapeutic outcome of cisplatin is limited due to its adverse side effects in normal tissues. Despite its potent antineoplastic effect, cisplatin is known by a relevant collateral action, for instance, acute renal failure. The aim of this study was to assess the effectiveness of Pituranthos chl...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | Journal of Toxicology |
| Online Access: | http://dx.doi.org/10.1155/2020/7054534 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832547136960462848 |
|---|---|
| author | Aida Lahmar Zaineb Dhaouefi Rihab Khlifi Fairouz Sioud Leila Chekir- Ghedira |
| author_facet | Aida Lahmar Zaineb Dhaouefi Rihab Khlifi Fairouz Sioud Leila Chekir- Ghedira |
| author_sort | Aida Lahmar |
| collection | DOAJ |
| description | The therapeutic outcome of cisplatin is limited due to its adverse side effects in normal tissues. Despite its potent antineoplastic effect, cisplatin is known by a relevant collateral action, for instance, acute renal failure. The aim of this study was to assess the effectiveness of Pituranthos chloranthus (PC) essential oil for contracting cisplatin-induced toxicity, in Balb/c mice. The standard mouse model of cisplatin-induced acute kidney injury (AKI), consisting of one intraperitoneal injection of cisplatin (20 mg/kg), was adopted. Mice were pretreated by intraperitoneal administration of PC (5 and 10 mg/Kg b.w) for one week. Cisplatin induced alteration in renal and liver functions, evidenced by increased serum biomarkers levels (creatinine, ALT, and AST). Significant mitigation of cisplatin-induced toxicity was confirmed by lowered levels of serum biomarkers and reduced DNA damage in liver and kidney. PC also restored the alterations in oxidative stress markers and proinflammatory cytokine IFN-γ level. Overall, this study provides, for the first time, that PC can be applied as an antioxidant-adjuvant treatment to mitigate cisplatin-induced renal failure. |
| format | Article |
| id | doaj-art-2de9d87e7e094c67ba168393f821da44 |
| institution | Kabale University |
| issn | 1687-8191 1687-8205 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Toxicology |
| spelling | doaj-art-2de9d87e7e094c67ba168393f821da442025-02-03T06:45:46ZengWileyJournal of Toxicology1687-81911687-82052020-01-01202010.1155/2020/70545347054534Pituranthos chloranthus Oil as an Antioxidant-Based Adjuvant Therapy against Cisplatin-Induced NephrotoxicityAida Lahmar0Zaineb Dhaouefi1Rihab Khlifi2Fairouz Sioud3Leila Chekir- Ghedira4Unit of Bioactive and Natural Substances and Biotechnology UR17ES49, Faculty of Dental Medicine, University of Monastir, Avicenna Street, Monastir 5000, TunisiaUnit of Bioactive and Natural Substances and Biotechnology UR17ES49, Faculty of Dental Medicine, University of Monastir, Avicenna Street, Monastir 5000, TunisiaUnit of Bioactive and Natural Substances and Biotechnology UR17ES49, Faculty of Dental Medicine, University of Monastir, Avicenna Street, Monastir 5000, TunisiaUnit of Bioactive and Natural Substances and Biotechnology UR17ES49, Faculty of Dental Medicine, University of Monastir, Avicenna Street, Monastir 5000, TunisiaUnit of Bioactive and Natural Substances and Biotechnology UR17ES49, Faculty of Dental Medicine, University of Monastir, Avicenna Street, Monastir 5000, TunisiaThe therapeutic outcome of cisplatin is limited due to its adverse side effects in normal tissues. Despite its potent antineoplastic effect, cisplatin is known by a relevant collateral action, for instance, acute renal failure. The aim of this study was to assess the effectiveness of Pituranthos chloranthus (PC) essential oil for contracting cisplatin-induced toxicity, in Balb/c mice. The standard mouse model of cisplatin-induced acute kidney injury (AKI), consisting of one intraperitoneal injection of cisplatin (20 mg/kg), was adopted. Mice were pretreated by intraperitoneal administration of PC (5 and 10 mg/Kg b.w) for one week. Cisplatin induced alteration in renal and liver functions, evidenced by increased serum biomarkers levels (creatinine, ALT, and AST). Significant mitigation of cisplatin-induced toxicity was confirmed by lowered levels of serum biomarkers and reduced DNA damage in liver and kidney. PC also restored the alterations in oxidative stress markers and proinflammatory cytokine IFN-γ level. Overall, this study provides, for the first time, that PC can be applied as an antioxidant-adjuvant treatment to mitigate cisplatin-induced renal failure.http://dx.doi.org/10.1155/2020/7054534 |
| spellingShingle | Aida Lahmar Zaineb Dhaouefi Rihab Khlifi Fairouz Sioud Leila Chekir- Ghedira Pituranthos chloranthus Oil as an Antioxidant-Based Adjuvant Therapy against Cisplatin-Induced Nephrotoxicity Journal of Toxicology |
| title | Pituranthos chloranthus Oil as an Antioxidant-Based Adjuvant Therapy against Cisplatin-Induced Nephrotoxicity |
| title_full | Pituranthos chloranthus Oil as an Antioxidant-Based Adjuvant Therapy against Cisplatin-Induced Nephrotoxicity |
| title_fullStr | Pituranthos chloranthus Oil as an Antioxidant-Based Adjuvant Therapy against Cisplatin-Induced Nephrotoxicity |
| title_full_unstemmed | Pituranthos chloranthus Oil as an Antioxidant-Based Adjuvant Therapy against Cisplatin-Induced Nephrotoxicity |
| title_short | Pituranthos chloranthus Oil as an Antioxidant-Based Adjuvant Therapy against Cisplatin-Induced Nephrotoxicity |
| title_sort | pituranthos chloranthus oil as an antioxidant based adjuvant therapy against cisplatin induced nephrotoxicity |
| url | http://dx.doi.org/10.1155/2020/7054534 |
| work_keys_str_mv | AT aidalahmar pituranthoschloranthusoilasanantioxidantbasedadjuvanttherapyagainstcisplatininducednephrotoxicity AT zainebdhaouefi pituranthoschloranthusoilasanantioxidantbasedadjuvanttherapyagainstcisplatininducednephrotoxicity AT rihabkhlifi pituranthoschloranthusoilasanantioxidantbasedadjuvanttherapyagainstcisplatininducednephrotoxicity AT fairouzsioud pituranthoschloranthusoilasanantioxidantbasedadjuvanttherapyagainstcisplatininducednephrotoxicity AT leilachekirghedira pituranthoschloranthusoilasanantioxidantbasedadjuvanttherapyagainstcisplatininducednephrotoxicity |