Insights into the Multidisciplinary Approach for Metastatic Acinic Cell Lung Carcinoma: The Pathologist’s Role in Romania Today
<b>Background/Objectives</b>: Acinic cell carcinoma (ACC) is a rare lung neoplasm that can affect both children and adults as a parenchymal or endobronchial mass. It is histologically similar to this kind of tumor described in salivary glands, but with a different immunophenotype. In gen...
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2025-01-01
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| Series: | Current Oncology |
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| author | Dorela-Codruta Lazureanu Amelia Burlea Robert Barna Daniela Cipu Mihaela Pasca Fenesan Ioan Icma Marioara Cornianu |
| author_facet | Dorela-Codruta Lazureanu Amelia Burlea Robert Barna Daniela Cipu Mihaela Pasca Fenesan Ioan Icma Marioara Cornianu |
| author_sort | Dorela-Codruta Lazureanu |
| collection | DOAJ |
| description | <b>Background/Objectives</b>: Acinic cell carcinoma (ACC) is a rare lung neoplasm that can affect both children and adults as a parenchymal or endobronchial mass. It is histologically similar to this kind of tumor described in salivary glands, but with a different immunophenotype. In general, it poses a reduced degree of malignancy, with indolent growth and a favorable prognosis, with exceptionally rare cases associated with recurring disease or lymph node metastases. <b>Methods</b>: When clinicians are facing puzzling symptomatology in their patients, the main role of the multidisciplinary team in their review of oncological cases is to recommend imagistic-guided biopsies. Tissues samples were routinely processed, stained with hematoxylin-eosin (HE) and periodic acid–Schiff (PAS), and submitted to complementary immunohistochemistry tests. <b>Results</b>: Histopathological reports were consistent for lung ACC with regional lymph node involvement and remote metastases. Oncological therapies followed. <b>Conclusions</b>: Postponements of the presentation to the doctor at the onset of symptoms, as well as a lack of periodic health control for people insured by national health insurance companies, often lead to medical, human and financial complications that are difficult to manage. The pathologist involved in the discussion of oncological cases brings his expertise in solving cases, certifying the evolution of tumors considered less aggressive, such as in the case of lung ACCs. |
| format | Article |
| id | doaj-art-2de8f775b3fc470fabe65d5b2abd5fe2 |
| institution | Kabale University |
| issn | 1198-0052 1718-7729 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj-art-2de8f775b3fc470fabe65d5b2abd5fe22025-01-24T13:28:26ZengMDPI AGCurrent Oncology1198-00521718-77292025-01-013213710.3390/curroncol32010037Insights into the Multidisciplinary Approach for Metastatic Acinic Cell Lung Carcinoma: The Pathologist’s Role in Romania TodayDorela-Codruta Lazureanu0Amelia Burlea1Robert Barna2Daniela Cipu3Mihaela Pasca Fenesan4Ioan Icma5Marioara Cornianu6Microscopic Morphology Department—Anatomical Pathology, ANAPATMOL Research Center, “Victor Babes” University of Medicine and Pharmacy, 300041 Timișoara, RomaniaPathology Department, Emergency County Hospital Arad, 310037 Arad, RomaniaMicroscopic Morphology Department—Anatomical Pathology, ANAPATMOL Research Center, “Victor Babes” University of Medicine and Pharmacy, 300041 Timișoara, RomaniaRadiology and Medical Imaging, “Victor Babes” University of Medicine and Pharmacy, 300041 Timișoara, RomaniaOncoHelp Hospital, 300239 Timisoara, RomaniaSurgery Department Ist Clinic, “Pius Brinzeu” Emergency County Clinical Hospital Timisoara, 300723 Timisoara, RomaniaMicroscopic Morphology Department—Anatomical Pathology, ANAPATMOL Research Center, “Victor Babes” University of Medicine and Pharmacy, 300041 Timișoara, Romania<b>Background/Objectives</b>: Acinic cell carcinoma (ACC) is a rare lung neoplasm that can affect both children and adults as a parenchymal or endobronchial mass. It is histologically similar to this kind of tumor described in salivary glands, but with a different immunophenotype. In general, it poses a reduced degree of malignancy, with indolent growth and a favorable prognosis, with exceptionally rare cases associated with recurring disease or lymph node metastases. <b>Methods</b>: When clinicians are facing puzzling symptomatology in their patients, the main role of the multidisciplinary team in their review of oncological cases is to recommend imagistic-guided biopsies. Tissues samples were routinely processed, stained with hematoxylin-eosin (HE) and periodic acid–Schiff (PAS), and submitted to complementary immunohistochemistry tests. <b>Results</b>: Histopathological reports were consistent for lung ACC with regional lymph node involvement and remote metastases. Oncological therapies followed. <b>Conclusions</b>: Postponements of the presentation to the doctor at the onset of symptoms, as well as a lack of periodic health control for people insured by national health insurance companies, often lead to medical, human and financial complications that are difficult to manage. The pathologist involved in the discussion of oncological cases brings his expertise in solving cases, certifying the evolution of tumors considered less aggressive, such as in the case of lung ACCs.https://www.mdpi.com/1718-7729/32/1/37acinic cell carcinomalungmetastasesancillary testsmultidisciplinary approach |
| spellingShingle | Dorela-Codruta Lazureanu Amelia Burlea Robert Barna Daniela Cipu Mihaela Pasca Fenesan Ioan Icma Marioara Cornianu Insights into the Multidisciplinary Approach for Metastatic Acinic Cell Lung Carcinoma: The Pathologist’s Role in Romania Today Current Oncology acinic cell carcinoma lung metastases ancillary tests multidisciplinary approach |
| title | Insights into the Multidisciplinary Approach for Metastatic Acinic Cell Lung Carcinoma: The Pathologist’s Role in Romania Today |
| title_full | Insights into the Multidisciplinary Approach for Metastatic Acinic Cell Lung Carcinoma: The Pathologist’s Role in Romania Today |
| title_fullStr | Insights into the Multidisciplinary Approach for Metastatic Acinic Cell Lung Carcinoma: The Pathologist’s Role in Romania Today |
| title_full_unstemmed | Insights into the Multidisciplinary Approach for Metastatic Acinic Cell Lung Carcinoma: The Pathologist’s Role in Romania Today |
| title_short | Insights into the Multidisciplinary Approach for Metastatic Acinic Cell Lung Carcinoma: The Pathologist’s Role in Romania Today |
| title_sort | insights into the multidisciplinary approach for metastatic acinic cell lung carcinoma the pathologist s role in romania today |
| topic | acinic cell carcinoma lung metastases ancillary tests multidisciplinary approach |
| url | https://www.mdpi.com/1718-7729/32/1/37 |
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