In Vitro Exposure to the Endocrine-Disrupting Chemical Climbazole Impairs Human Sperm Motility, Hormonal Signalling, and Mitochondrial Activity

In Vitro Exposure to the Endocrine-Disrupting Chemical Climbazole Impairs Human Sperm Motility, Hormonal Signalling, and Mitochondrial Activity

This study explores the endocrine-disrupting effects of climbazole (CBZ), an environmental and lifestyle stressor, on male fertility. The impact of CBZ on sperm vitality, motility, and molecular pathways related to hormone receptors and apoptosis was evaluated, in non-capacitated and capacitated con...

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Bibliographic Details
Main Authors: Eugenia Annunzi, Francesca Paola Luongo, Francesca Girolamo, Rosetta Ponchia, Sofia Passaponti, Paola Piomboni, Alice Luddi
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Cells
Subjects:
endocrine-disrupting chemicals (EDCs)
male fertility
climbazole (CBZ)
semen quality
oxidative stress
Online Access:https://www.mdpi.com/2073-4409/14/6/427
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