Elucidating the Role of the T Cell Receptor Repertoire in Myelodysplastic Neoplasms and Acute Myeloid Leukemia
T cells, as integral components of the adaptive immune system, recognize diverse antigens through unique T cell receptors (TCRs). To achieve this, during T cell maturation, the thymus generates a wide repertoire of TCRs. This is essential for understanding cancer evolution, progression, and the effi...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Series: | Diseases |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-9721/13/1/19 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832588681983033344 |
|---|---|
| author | Georgios Petros Barakos Vasileios Georgoulis Epameinondas Koumpis Eleftheria Hatzimichael |
| author_facet | Georgios Petros Barakos Vasileios Georgoulis Epameinondas Koumpis Eleftheria Hatzimichael |
| author_sort | Georgios Petros Barakos |
| collection | DOAJ |
| description | T cells, as integral components of the adaptive immune system, recognize diverse antigens through unique T cell receptors (TCRs). To achieve this, during T cell maturation, the thymus generates a wide repertoire of TCRs. This is essential for understanding cancer evolution, progression, and the efficacy of immunotherapies. Myelodysplastic neoplasms (MDS) and acute myeloid leukemia (AML) are hematological neoplasms that are characterized by immune evasion mechanisms, with immunotherapy giving only modest results thus far. Our review of TCR repertoire dynamics in these diseases reveals distinct patterns: MDS patients show increased TCR clonality with disease progression, while AML exhibits varied TCR signatures depending on disease stage and treatment response. Understanding these patterns has important clinical implications, as TCR repertoire metrics may serve as potential biomarkers for disease progression and treatment response, particularly in the context of immunotherapy and stem cell transplantation. These insights could guide patient stratification and treatment selection, ultimately improving therapeutic outcomes in MDS and AML. |
| format | Article |
| id | doaj-art-2de805aa145b40d2983d2b0a18e75e25 |
| institution | Kabale University |
| issn | 2079-9721 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diseases |
| spelling | doaj-art-2de805aa145b40d2983d2b0a18e75e252025-01-24T13:29:16ZengMDPI AGDiseases2079-97212025-01-011311910.3390/diseases13010019Elucidating the Role of the T Cell Receptor Repertoire in Myelodysplastic Neoplasms and Acute Myeloid LeukemiaGeorgios Petros Barakos0Vasileios Georgoulis1Epameinondas Koumpis2Eleftheria Hatzimichael3First Department of Internal Medicine, General Hospital of Piraeus “Tzaneio”, 18536 Piraeus, GreeceDepartment of Haematology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45500 Ioannina, GreeceDepartment of Haematology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45500 Ioannina, GreeceDepartment of Haematology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45500 Ioannina, GreeceT cells, as integral components of the adaptive immune system, recognize diverse antigens through unique T cell receptors (TCRs). To achieve this, during T cell maturation, the thymus generates a wide repertoire of TCRs. This is essential for understanding cancer evolution, progression, and the efficacy of immunotherapies. Myelodysplastic neoplasms (MDS) and acute myeloid leukemia (AML) are hematological neoplasms that are characterized by immune evasion mechanisms, with immunotherapy giving only modest results thus far. Our review of TCR repertoire dynamics in these diseases reveals distinct patterns: MDS patients show increased TCR clonality with disease progression, while AML exhibits varied TCR signatures depending on disease stage and treatment response. Understanding these patterns has important clinical implications, as TCR repertoire metrics may serve as potential biomarkers for disease progression and treatment response, particularly in the context of immunotherapy and stem cell transplantation. These insights could guide patient stratification and treatment selection, ultimately improving therapeutic outcomes in MDS and AML.https://www.mdpi.com/2079-9721/13/1/19myelodysplastic syndromesacute myeloid leukemiaT cell receptorTCR repertoireimmunotherapyhematopoietic stem cell transplantation |
| spellingShingle | Georgios Petros Barakos Vasileios Georgoulis Epameinondas Koumpis Eleftheria Hatzimichael Elucidating the Role of the T Cell Receptor Repertoire in Myelodysplastic Neoplasms and Acute Myeloid Leukemia Diseases myelodysplastic syndromes acute myeloid leukemia T cell receptor TCR repertoire immunotherapy hematopoietic stem cell transplantation |
| title | Elucidating the Role of the T Cell Receptor Repertoire in Myelodysplastic Neoplasms and Acute Myeloid Leukemia |
| title_full | Elucidating the Role of the T Cell Receptor Repertoire in Myelodysplastic Neoplasms and Acute Myeloid Leukemia |
| title_fullStr | Elucidating the Role of the T Cell Receptor Repertoire in Myelodysplastic Neoplasms and Acute Myeloid Leukemia |
| title_full_unstemmed | Elucidating the Role of the T Cell Receptor Repertoire in Myelodysplastic Neoplasms and Acute Myeloid Leukemia |
| title_short | Elucidating the Role of the T Cell Receptor Repertoire in Myelodysplastic Neoplasms and Acute Myeloid Leukemia |
| title_sort | elucidating the role of the t cell receptor repertoire in myelodysplastic neoplasms and acute myeloid leukemia |
| topic | myelodysplastic syndromes acute myeloid leukemia T cell receptor TCR repertoire immunotherapy hematopoietic stem cell transplantation |
| url | https://www.mdpi.com/2079-9721/13/1/19 |
| work_keys_str_mv | AT georgiospetrosbarakos elucidatingtheroleofthetcellreceptorrepertoireinmyelodysplasticneoplasmsandacutemyeloidleukemia AT vasileiosgeorgoulis elucidatingtheroleofthetcellreceptorrepertoireinmyelodysplasticneoplasmsandacutemyeloidleukemia AT epameinondaskoumpis elucidatingtheroleofthetcellreceptorrepertoireinmyelodysplasticneoplasmsandacutemyeloidleukemia AT eleftheriahatzimichael elucidatingtheroleofthetcellreceptorrepertoireinmyelodysplasticneoplasmsandacutemyeloidleukemia |