Experimentally Induced Pulpal Lesion and Substance P Expression: Effect of Ketoprofen—A Preliminary Study
Objectives. To evaluate substance P (SP) and the effect of ketoprofen administration, a nonsteroidal anti-inflammatory drug (NSAID), on SP in the pulp of upper third molars with experimentally induced pulpal lesion. Materials and Methods. A sample of 20 young systemically healthy adults of both sexe...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | International Journal of Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2016/6820781 |
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| author | Gian Marco Abbate Paola Sacerdote Giada Amodeo Alessandro Mangano Luca Levrini |
| author_facet | Gian Marco Abbate Paola Sacerdote Giada Amodeo Alessandro Mangano Luca Levrini |
| author_sort | Gian Marco Abbate |
| collection | DOAJ |
| description | Objectives. To evaluate substance P (SP) and the effect of ketoprofen administration, a nonsteroidal anti-inflammatory drug (NSAID), on SP in the pulp of upper third molars with experimentally induced pulpal lesion. Materials and Methods. A sample of 20 young systemically healthy adults of both sexes, nonsmokers, with a healthy upper third molar to extract for orthodontic purposes, was selected. Prior to the procedure, an inflammatory process was generated by mechanical exposure of the pulp. After 15 minutes, the pulp was collected using a sterile barbed broach. SP levels were determined by using a commercially available enzyme immunoassay (ELISA) kit. The subjects were randomly divided into two groups: group 1 received a dose of ketoprofen 30 minutes prior to the experimental procedure. The subjects of group 2 did not receive any kind of drug administration. The patients were asked to complete a diary on the postoperative pain. Results. No statistically significant difference could be detected in SP expression between the two groups. In group 1, pain manifestation was significantly delayed in comparison with group 2. Conclusions. Preventive administration of ketoprofen did not significantly affect the pulpal levels of SP but resulted in a significantly postponed manifestation of pain after extraction. |
| format | Article |
| id | doaj-art-2de3b6cbf45448a48e865b9abe6c863a |
| institution | Kabale University |
| issn | 1687-8728 1687-8736 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Dentistry |
| spelling | doaj-art-2de3b6cbf45448a48e865b9abe6c863a2025-02-03T01:29:56ZengWileyInternational Journal of Dentistry1687-87281687-87362016-01-01201610.1155/2016/68207816820781Experimentally Induced Pulpal Lesion and Substance P Expression: Effect of Ketoprofen—A Preliminary StudyGian Marco Abbate0Paola Sacerdote1Giada Amodeo2Alessandro Mangano3Luca Levrini4Faculty of Dentistry and Oral Hygiene, University of Insubria, Via Piatti 10, 21100 Varese, ItalyDipartimento di Scienze Farmacologiche e Biomolecolari, University of Milan, 20129 Milano, ItalyDipartimento di Scienze Farmacologiche e Biomolecolari, University of Milan, 20129 Milano, ItalyFaculty of Dentistry and Oral Hygiene, University of Insubria, Via Piatti 10, 21100 Varese, ItalyFaculty of Dentistry and Oral Hygiene, University of Insubria, Via Piatti 10, 21100 Varese, ItalyObjectives. To evaluate substance P (SP) and the effect of ketoprofen administration, a nonsteroidal anti-inflammatory drug (NSAID), on SP in the pulp of upper third molars with experimentally induced pulpal lesion. Materials and Methods. A sample of 20 young systemically healthy adults of both sexes, nonsmokers, with a healthy upper third molar to extract for orthodontic purposes, was selected. Prior to the procedure, an inflammatory process was generated by mechanical exposure of the pulp. After 15 minutes, the pulp was collected using a sterile barbed broach. SP levels were determined by using a commercially available enzyme immunoassay (ELISA) kit. The subjects were randomly divided into two groups: group 1 received a dose of ketoprofen 30 minutes prior to the experimental procedure. The subjects of group 2 did not receive any kind of drug administration. The patients were asked to complete a diary on the postoperative pain. Results. No statistically significant difference could be detected in SP expression between the two groups. In group 1, pain manifestation was significantly delayed in comparison with group 2. Conclusions. Preventive administration of ketoprofen did not significantly affect the pulpal levels of SP but resulted in a significantly postponed manifestation of pain after extraction.http://dx.doi.org/10.1155/2016/6820781 |
| spellingShingle | Gian Marco Abbate Paola Sacerdote Giada Amodeo Alessandro Mangano Luca Levrini Experimentally Induced Pulpal Lesion and Substance P Expression: Effect of Ketoprofen—A Preliminary Study International Journal of Dentistry |
| title | Experimentally Induced Pulpal Lesion and Substance P Expression: Effect of Ketoprofen—A Preliminary Study |
| title_full | Experimentally Induced Pulpal Lesion and Substance P Expression: Effect of Ketoprofen—A Preliminary Study |
| title_fullStr | Experimentally Induced Pulpal Lesion and Substance P Expression: Effect of Ketoprofen—A Preliminary Study |
| title_full_unstemmed | Experimentally Induced Pulpal Lesion and Substance P Expression: Effect of Ketoprofen—A Preliminary Study |
| title_short | Experimentally Induced Pulpal Lesion and Substance P Expression: Effect of Ketoprofen—A Preliminary Study |
| title_sort | experimentally induced pulpal lesion and substance p expression effect of ketoprofen a preliminary study |
| url | http://dx.doi.org/10.1155/2016/6820781 |
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