Maternal exposure to fullerenols impairs placental development in mice by inhibiting estriol synthesis and reducing ERα

Maternal exposure to fullerenols impairs placental development in mice by inhibiting estriol synthesis and reducing ERα

Abstract Fullerenols, a water-soluble polyhydroxy derivative of fullerene, hold promise in medical and materials science due to their unique properties. However, concerns about their potential embryotoxicity remain. Using a pregnancy mouse model and metabolomics analysis, our findings reveal that fu...

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Bibliographic Details
Main Authors: Qing He, Jiali Yuan, Huihui Yang, Ting Du, Siqing Hu, Ling Ding, Wei Yan, Panpan Chen, Jing Li, Zhenyao Huang
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Nanobiotechnology
Subjects:
Fullerenols
Placental development
Estriol
Oxidative stress
Online Access:https://doi.org/10.1186/s12951-025-03121-7
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