Role of glucocorticoids in neutrophil and endothelial adhesion molecule expression and function
Glucocorticoids are very effective inhibitors of both the acute and chronic inflammatory response. In this study the hypothesis that glucocorticoids inhibit an early component of the inflammatory response, neutrophil adhesion to endothelium, by down-regulation of adhesion molecules on neutrophils or...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1992-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935192000176 |
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| _version_ | 1832556872632107008 |
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| author | Kevin D. Forsyth Vivienne Talbot |
| author_facet | Kevin D. Forsyth Vivienne Talbot |
| author_sort | Kevin D. Forsyth |
| collection | DOAJ |
| description | Glucocorticoids are very effective inhibitors of both the acute and chronic inflammatory response. In this study the hypothesis that glucocorticoids inhibit an early component of the inflammatory response, neutrophil adhesion to endothelium, by down-regulation of adhesion molecules on neutrophils or endothelium was examined. No effect of dexamethasone on neutrophil adhesion to endothelium or of antigen expression by neutrophils or endothelium was found. The mechanism of action of glucocorticoids in the inflammatory response is probably not mediated by alterations in adhesion molecules. |
| format | Article |
| id | doaj-art-2dd7038b69854297ac9df61a04be5330 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1992-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-2dd7038b69854297ac9df61a04be53302025-02-03T05:44:11ZengWileyMediators of Inflammation0962-93511466-18611992-01-011210110610.1155/S0962935192000176Role of glucocorticoids in neutrophil and endothelial adhesion molecule expression and functionKevin D. Forsyth0Vivienne Talbot1Department of Immunology, Princess Margaret Hospital for Children, Box D184, GPO, Perth 6001, AustraliaDepartment of Immunology, Princess Margaret Hospital for Children, Box D184, GPO, Perth 6001, AustraliaGlucocorticoids are very effective inhibitors of both the acute and chronic inflammatory response. In this study the hypothesis that glucocorticoids inhibit an early component of the inflammatory response, neutrophil adhesion to endothelium, by down-regulation of adhesion molecules on neutrophils or endothelium was examined. No effect of dexamethasone on neutrophil adhesion to endothelium or of antigen expression by neutrophils or endothelium was found. The mechanism of action of glucocorticoids in the inflammatory response is probably not mediated by alterations in adhesion molecules.http://dx.doi.org/10.1155/S0962935192000176 |
| spellingShingle | Kevin D. Forsyth Vivienne Talbot Role of glucocorticoids in neutrophil and endothelial adhesion molecule expression and function Mediators of Inflammation |
| title | Role of glucocorticoids in neutrophil and endothelial adhesion molecule expression and function |
| title_full | Role of glucocorticoids in neutrophil and endothelial adhesion molecule expression and function |
| title_fullStr | Role of glucocorticoids in neutrophil and endothelial adhesion molecule expression and function |
| title_full_unstemmed | Role of glucocorticoids in neutrophil and endothelial adhesion molecule expression and function |
| title_short | Role of glucocorticoids in neutrophil and endothelial adhesion molecule expression and function |
| title_sort | role of glucocorticoids in neutrophil and endothelial adhesion molecule expression and function |
| url | http://dx.doi.org/10.1155/S0962935192000176 |
| work_keys_str_mv | AT kevindforsyth roleofglucocorticoidsinneutrophilandendothelialadhesionmoleculeexpressionandfunction AT viviennetalbot roleofglucocorticoidsinneutrophilandendothelialadhesionmoleculeexpressionandfunction |