Effect of Dementia on the Use of Drugs for Secondary Prevention of Ischemic Heart Disease
Background. Dementia and cardiovascular disease (CVD) are frequently comorbid. The presence of dementia may have an effect on how CVD is treated. Objective. To examine the effect of dementia on the use of four medications recommended for secondary prevention of ischemic heart disease (IHD): angioten...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Aging Research |
| Online Access: | http://dx.doi.org/10.1155/2014/897671 |
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| _version_ | 1832565151274893312 |
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| author | Nicole R. Fowler Amber E. Barnato Howard B. Degenholtz Angela M. Curcio James T. Becker Lewis H. Kuller Oscar L. Lopez |
| author_facet | Nicole R. Fowler Amber E. Barnato Howard B. Degenholtz Angela M. Curcio James T. Becker Lewis H. Kuller Oscar L. Lopez |
| author_sort | Nicole R. Fowler |
| collection | DOAJ |
| description | Background. Dementia and cardiovascular disease (CVD) are frequently comorbid. The presence of dementia may have an effect on how CVD is treated. Objective. To examine the effect of dementia on the use of four medications recommended for secondary prevention of ischemic heart disease (IHD): angiotensin-converting enzyme inhibitors, beta-blockers, lipid-lowering medications, and antiplatelet medications. Design. Retrospective analysis of data from the Cardiovascular Health Study: Cognition Study. Setting and Subjects. 1,087 older adults in four US states who had or developed IHD between 1989 and 1998. Methods. Generalized estimating equations to explore the association between dementia and the use of guideline-recommended medications for the secondary prevention of IHD. Results. The length of follow-up for the cohort was 8.7 years and 265 (24%) had or developed dementia during the study. Use of medications for the secondary prevention of IHD for patients with and without dementia increased during the study period. In models, subjects with dementia were not less likely to use any one particular class of medication but were less likely to use two or more classes of medications as a group (OR, 0.60; 95% CI, 0.36–0.99). Conclusions. Subjects with dementia used fewer guideline-recommended medications for the secondary prevention of IHD than those without dementia. |
| format | Article |
| id | doaj-art-2dc1bb83e6bd424d81d364279c38475d |
| institution | Kabale University |
| issn | 2090-2204 2090-2212 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Aging Research |
| spelling | doaj-art-2dc1bb83e6bd424d81d364279c38475d2025-02-03T01:09:10ZengWileyJournal of Aging Research2090-22042090-22122014-01-01201410.1155/2014/897671897671Effect of Dementia on the Use of Drugs for Secondary Prevention of Ischemic Heart DiseaseNicole R. Fowler0Amber E. Barnato1Howard B. Degenholtz2Angela M. Curcio3James T. Becker4Lewis H. Kuller5Oscar L. Lopez6Division of General Internal Medicine, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USADivision of General Internal Medicine, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USADepartment of Health Policy and Management, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USACollege of Medicine, Drexel University, Philadelphia, PA 19129, USADepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USADepartment of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USADepartment of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USABackground. Dementia and cardiovascular disease (CVD) are frequently comorbid. The presence of dementia may have an effect on how CVD is treated. Objective. To examine the effect of dementia on the use of four medications recommended for secondary prevention of ischemic heart disease (IHD): angiotensin-converting enzyme inhibitors, beta-blockers, lipid-lowering medications, and antiplatelet medications. Design. Retrospective analysis of data from the Cardiovascular Health Study: Cognition Study. Setting and Subjects. 1,087 older adults in four US states who had or developed IHD between 1989 and 1998. Methods. Generalized estimating equations to explore the association between dementia and the use of guideline-recommended medications for the secondary prevention of IHD. Results. The length of follow-up for the cohort was 8.7 years and 265 (24%) had or developed dementia during the study. Use of medications for the secondary prevention of IHD for patients with and without dementia increased during the study period. In models, subjects with dementia were not less likely to use any one particular class of medication but were less likely to use two or more classes of medications as a group (OR, 0.60; 95% CI, 0.36–0.99). Conclusions. Subjects with dementia used fewer guideline-recommended medications for the secondary prevention of IHD than those without dementia.http://dx.doi.org/10.1155/2014/897671 |
| spellingShingle | Nicole R. Fowler Amber E. Barnato Howard B. Degenholtz Angela M. Curcio James T. Becker Lewis H. Kuller Oscar L. Lopez Effect of Dementia on the Use of Drugs for Secondary Prevention of Ischemic Heart Disease Journal of Aging Research |
| title | Effect of Dementia on the Use of Drugs for Secondary Prevention of Ischemic Heart Disease |
| title_full | Effect of Dementia on the Use of Drugs for Secondary Prevention of Ischemic Heart Disease |
| title_fullStr | Effect of Dementia on the Use of Drugs for Secondary Prevention of Ischemic Heart Disease |
| title_full_unstemmed | Effect of Dementia on the Use of Drugs for Secondary Prevention of Ischemic Heart Disease |
| title_short | Effect of Dementia on the Use of Drugs for Secondary Prevention of Ischemic Heart Disease |
| title_sort | effect of dementia on the use of drugs for secondary prevention of ischemic heart disease |
| url | http://dx.doi.org/10.1155/2014/897671 |
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