PPARs in Calorie Restricted and Genetically Long-Lived Mice
Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear receptors superfamily. The three subtypes, PPARα, PPARγ, and PPARβ/δ, are expressed in multiple organs. These transcription factors regulate different physiological functions such as energy metabolism (including li...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2007-01-01
|
| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2007/28436 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear receptors
superfamily. The three subtypes, PPARα, PPARγ, and PPARβ/δ, are expressed in multiple organs. These transcription factors regulate different physiological
functions such as energy metabolism (including lipid and carbohydrate metabolism), insulin action, and
immunity and inflammation, and apparently also act as important mediators of longevity and aging. Calorie restriction (CR) is the most effective intervention known to delay aging and increase lifespan.
Calorie restriction affects the same physiological functions as PPARs. This review summarizes recent
findings on the effects of CR and aging on the expression of PPARγ, α, and β/δ in mice and discusses possible involvement of PPARs in mediating the effects of murine
longevity genes. The levels of PPARs change with age and CR appears to prevent these alterations
which make “PPARs-CR-AGING” dependence of considerable interest. |
|---|---|
| ISSN: | 1687-4757 1687-4765 |