Impact of psychostimulants on microbiota and short-chain fatty acids alterations in children with attention-deficit/hyperactivity disorder
Abstract Attention-deficit/hyperactivity disorder (ADHD), a common neurodevelopmental disorder in children, is associated with alterations in gut microbiota and short-chain fatty acids (SCFAs), which are metabolites influencing the gut-brain axis. Evidence suggests that psychostimulant medications,...
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| Format: | Article |
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Nature Portfolio
2025-01-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-87546-y |
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| author | Nonglak Boonchooduang Orawan Louthrenoo Narueporn Likhitweerawong Chanon Kunasol Chanisa Thonusin Sirawit Sriwichaiin Wichwara Nawara Nipon Chattipakorn Siriporn C. Chattipakorn |
| author_facet | Nonglak Boonchooduang Orawan Louthrenoo Narueporn Likhitweerawong Chanon Kunasol Chanisa Thonusin Sirawit Sriwichaiin Wichwara Nawara Nipon Chattipakorn Siriporn C. Chattipakorn |
| author_sort | Nonglak Boonchooduang |
| collection | DOAJ |
| description | Abstract Attention-deficit/hyperactivity disorder (ADHD), a common neurodevelopmental disorder in children, is associated with alterations in gut microbiota and short-chain fatty acids (SCFAs), which are metabolites influencing the gut-brain axis. Evidence suggests that psychostimulant medications, widely used to manage ADHD symptoms, may also impact gut microbiota composition and SCFA levels. This study explores these potential effects by examining gut microbiota profiles and SCFA concentrations in unmedicated and medicated children with ADHD, compared to healthy controls. Fecal samples from 30 children aged 6–12 years (10 unmedicated ADHD, 10 medicated ADHD, and 10 healthy controls) were analyzed using 16 S rRNA sequencing and targeted metabolomics. Unmedicated ADHD children show distinct gut microbiota profiles, with lower level of Tyzzerella, Prevotellaceae, and Coriobacteriaceae, compared to controls. Notably, propionic acid levels were negatively associated with ADHD symptom severity, suggesting a potential biomarker role. Medicated ADHD children showed lower gut microbial diversity, unique taxa, and lower SCFA levels, compared to unmedicated children with ADHD. These findings suggest that gut microbiota and SCFAs may be linked to ADHD symptomatology, underscoring the importance of gut-brain interactions in ADHD. This study highlights the potential of gut health monitoring as part of future ADHD management strategies. |
| format | Article |
| id | doaj-art-2dbbc57c09414757b1bac9f38e0c8c3c |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-2dbbc57c09414757b1bac9f38e0c8c3c2025-01-26T12:29:23ZengNature PortfolioScientific Reports2045-23222025-01-0115111610.1038/s41598-025-87546-yImpact of psychostimulants on microbiota and short-chain fatty acids alterations in children with attention-deficit/hyperactivity disorderNonglak Boonchooduang0Orawan Louthrenoo1Narueporn Likhitweerawong2Chanon Kunasol3Chanisa Thonusin4Sirawit Sriwichaiin5Wichwara Nawara6Nipon Chattipakorn7Siriporn C. Chattipakorn8Division of Developmental and Behavioral Pediatrics, Department of Pediatrics, Faculty of Medicine, Chiang Mai UniversityDivision of Developmental and Behavioral Pediatrics, Department of Pediatrics, Faculty of Medicine, Chiang Mai UniversityDivision of Developmental and Behavioral Pediatrics, Department of Pediatrics, Faculty of Medicine, Chiang Mai UniversityNeurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai UniversityNeurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai UniversityNeurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai UniversityNeurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai UniversityNeurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai UniversityNeurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai UniversityAbstract Attention-deficit/hyperactivity disorder (ADHD), a common neurodevelopmental disorder in children, is associated with alterations in gut microbiota and short-chain fatty acids (SCFAs), which are metabolites influencing the gut-brain axis. Evidence suggests that psychostimulant medications, widely used to manage ADHD symptoms, may also impact gut microbiota composition and SCFA levels. This study explores these potential effects by examining gut microbiota profiles and SCFA concentrations in unmedicated and medicated children with ADHD, compared to healthy controls. Fecal samples from 30 children aged 6–12 years (10 unmedicated ADHD, 10 medicated ADHD, and 10 healthy controls) were analyzed using 16 S rRNA sequencing and targeted metabolomics. Unmedicated ADHD children show distinct gut microbiota profiles, with lower level of Tyzzerella, Prevotellaceae, and Coriobacteriaceae, compared to controls. Notably, propionic acid levels were negatively associated with ADHD symptom severity, suggesting a potential biomarker role. Medicated ADHD children showed lower gut microbial diversity, unique taxa, and lower SCFA levels, compared to unmedicated children with ADHD. These findings suggest that gut microbiota and SCFAs may be linked to ADHD symptomatology, underscoring the importance of gut-brain interactions in ADHD. This study highlights the potential of gut health monitoring as part of future ADHD management strategies.https://doi.org/10.1038/s41598-025-87546-yADHDGut microbiotaSCFAsPsychostimulantsChildrenBiomarkers |
| spellingShingle | Nonglak Boonchooduang Orawan Louthrenoo Narueporn Likhitweerawong Chanon Kunasol Chanisa Thonusin Sirawit Sriwichaiin Wichwara Nawara Nipon Chattipakorn Siriporn C. Chattipakorn Impact of psychostimulants on microbiota and short-chain fatty acids alterations in children with attention-deficit/hyperactivity disorder Scientific Reports ADHD Gut microbiota SCFAs Psychostimulants Children Biomarkers |
| title | Impact of psychostimulants on microbiota and short-chain fatty acids alterations in children with attention-deficit/hyperactivity disorder |
| title_full | Impact of psychostimulants on microbiota and short-chain fatty acids alterations in children with attention-deficit/hyperactivity disorder |
| title_fullStr | Impact of psychostimulants on microbiota and short-chain fatty acids alterations in children with attention-deficit/hyperactivity disorder |
| title_full_unstemmed | Impact of psychostimulants on microbiota and short-chain fatty acids alterations in children with attention-deficit/hyperactivity disorder |
| title_short | Impact of psychostimulants on microbiota and short-chain fatty acids alterations in children with attention-deficit/hyperactivity disorder |
| title_sort | impact of psychostimulants on microbiota and short chain fatty acids alterations in children with attention deficit hyperactivity disorder |
| topic | ADHD Gut microbiota SCFAs Psychostimulants Children Biomarkers |
| url | https://doi.org/10.1038/s41598-025-87546-y |
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