Role of TLR4 rs4986790A>G and rs4986791C>T Polymorphisms in the Risk of Inflammatory Bowel Disease
Objective. The present meta-analysis investigated the contribution of TLR4 rs4986790A>G and rs4986791C>T genetic polymorphisms in increasing the risk of inflammatory bowel disease (IBD). Methods. Databases were searched using a combination of keywords related to TLR4 and IBD. Relevant studies...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2015/141070 |
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| author | Ran Ao Ying Wang Dao-Rong Zhnag Ya-Qi Du |
| author_facet | Ran Ao Ying Wang Dao-Rong Zhnag Ya-Qi Du |
| author_sort | Ran Ao |
| collection | DOAJ |
| description | Objective. The present meta-analysis investigated the contribution of TLR4 rs4986790A>G and rs4986791C>T genetic polymorphisms in increasing the risk of inflammatory bowel disease (IBD). Methods. Databases were searched using a combination of keywords related to TLR4 and IBD. Relevant studies were selected based on strict inclusion and exclusion criteria. Meta-analysis of the data extracted from the selected studies was performed using CMA 2.0 statistical analysis software. Results. Out of the 70 studies retrieved by database search, only 13 studies were eligible for inclusion in this meta-analysis and these 13 studies contained a total number of 4409 IBD patients and 5693 healthy controls. The meta-analysis results demonstrated that TLR4 rs4986790A>G polymorphism is associated with an increased risk of IBD (allele model: OR = 1.268, 95% CI = 1.124~1.431, and P<0.001; dominant model: OR = 1.240, 95% CI = 1.090~1.409, and P=0.001). Similarly, TLR4 rs4986791C>T polymorphism also conferred an increased risk of IBD (allele model: OR = 1.259, 95% CI = 1.092~1.453, and P=0.002; dominant model: OR = 1.246, 95% CI = 1.072~1.447, and P=0.004). Conclusion. Our meta-analysis results demonstrate that TLR4 rs4986790A>G and rs4986791C>T genetic polymorphisms are associated with the etiopathogenesis of IBD. |
| format | Article |
| id | doaj-art-2db6ed224ced4cbbae9e741ae4064df5 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-2db6ed224ced4cbbae9e741ae4064df52025-02-03T01:11:07ZengWileyGastroenterology Research and Practice1687-61211687-630X2015-01-01201510.1155/2015/141070141070Role of TLR4 rs4986790A>G and rs4986791C>T Polymorphisms in the Risk of Inflammatory Bowel DiseaseRan Ao0Ying Wang1Dao-Rong Zhnag2Ya-Qi Du3Department of Gastroenterology, First Affiliated Hospital of China Medical University, Shenyang 110001, ChinaDepartment of Gastroenterology, First Affiliated Hospital of China Medical University, Shenyang 110001, ChinaDepartment of Pathophysiology, College of Basic Medical Sciences, China Medical University, Shenyang 110001, ChinaDepartment of Gastroenterology, First Affiliated Hospital of China Medical University, Shenyang 110001, ChinaObjective. The present meta-analysis investigated the contribution of TLR4 rs4986790A>G and rs4986791C>T genetic polymorphisms in increasing the risk of inflammatory bowel disease (IBD). Methods. Databases were searched using a combination of keywords related to TLR4 and IBD. Relevant studies were selected based on strict inclusion and exclusion criteria. Meta-analysis of the data extracted from the selected studies was performed using CMA 2.0 statistical analysis software. Results. Out of the 70 studies retrieved by database search, only 13 studies were eligible for inclusion in this meta-analysis and these 13 studies contained a total number of 4409 IBD patients and 5693 healthy controls. The meta-analysis results demonstrated that TLR4 rs4986790A>G polymorphism is associated with an increased risk of IBD (allele model: OR = 1.268, 95% CI = 1.124~1.431, and P<0.001; dominant model: OR = 1.240, 95% CI = 1.090~1.409, and P=0.001). Similarly, TLR4 rs4986791C>T polymorphism also conferred an increased risk of IBD (allele model: OR = 1.259, 95% CI = 1.092~1.453, and P=0.002; dominant model: OR = 1.246, 95% CI = 1.072~1.447, and P=0.004). Conclusion. Our meta-analysis results demonstrate that TLR4 rs4986790A>G and rs4986791C>T genetic polymorphisms are associated with the etiopathogenesis of IBD.http://dx.doi.org/10.1155/2015/141070 |
| spellingShingle | Ran Ao Ying Wang Dao-Rong Zhnag Ya-Qi Du Role of TLR4 rs4986790A>G and rs4986791C>T Polymorphisms in the Risk of Inflammatory Bowel Disease Gastroenterology Research and Practice |
| title | Role of TLR4 rs4986790A>G and rs4986791C>T Polymorphisms in the Risk of Inflammatory Bowel Disease |
| title_full | Role of TLR4 rs4986790A>G and rs4986791C>T Polymorphisms in the Risk of Inflammatory Bowel Disease |
| title_fullStr | Role of TLR4 rs4986790A>G and rs4986791C>T Polymorphisms in the Risk of Inflammatory Bowel Disease |
| title_full_unstemmed | Role of TLR4 rs4986790A>G and rs4986791C>T Polymorphisms in the Risk of Inflammatory Bowel Disease |
| title_short | Role of TLR4 rs4986790A>G and rs4986791C>T Polymorphisms in the Risk of Inflammatory Bowel Disease |
| title_sort | role of tlr4 rs4986790a g and rs4986791c t polymorphisms in the risk of inflammatory bowel disease |
| url | http://dx.doi.org/10.1155/2015/141070 |
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