Evaluation of the inhibitory effect of Gingerol on bacteria and fungi isolated from the vagina
Abstract Background: Gingerol is extracted from the rhizomes of ginger. It showed a clear effect on the bacteria and the Candida isolation from the vagina, and the highest effect was at a concentration of 30 mg/mL. The positive bacteria are more responsive to gingerol than the negative bacteria; gin...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-01-01
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| Series: | Medical Journal of Babylon |
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| Online Access: | https://doi.org/10.4103/MJBL.MJBL_152_23 |
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| author | Heba Hadid Rashed Ibtihal Muiz Al-Hussaini Ali H. Al-Marzoqi |
| author_facet | Heba Hadid Rashed Ibtihal Muiz Al-Hussaini Ali H. Al-Marzoqi |
| author_sort | Heba Hadid Rashed |
| collection | DOAJ |
| description | Abstract Background: Gingerol is extracted from the rhizomes of ginger. It showed a clear effect on the bacteria and the Candida isolation from the vagina, and the highest effect was at a concentration of 30 mg/mL. The positive bacteria are more responsive to gingerol than the negative bacteria; gingerol is a great inhibitory activity compared to antibiotics on bacteria. Objectives: The aim of the article is to test the sensitivity of bacteria and Candida to gingerol and some antibiotics. Materials and Methods: In this study, we detected the presence of the phytochemical compounds present in the Zingiber officinale and the process of extraction of gingerol from ginger by HPLC technology, and tested different concentrations of gingerol for their effect on bacteria and fungi isolated from the vagina. Some antibiotics such as (tobramycin and kanamycin) on Staphylococcus aureus and ciprofloxacin and doxycycline on Klebsiella spp. and Escherichia coli and antifungal itraconazole and nystatin on Candida species. Results: Gingerol showed a clear effect on bacteria and Candida isolation from the vagina, and the highest effect was at a concentration of 30 mg/mL. Gram-positive bacteria S. aureus is more sensitive to gingerol than the Gram-negative bacteria E. coli and Klebsiella. Gingerol has a great inhibitory activity compared to antibiotics on bacteria and the highest effect on Candida albicans more than Candida tropicalis and Candida krusei. Conclusion: Through the results, ginger contains many pharaohs and the most important of these is an active compound gingerol that has anti-inflammatory properties through its ability to inhibit the growth of bacteria and Candida and had more impact on microorganisms than antibiotics. |
| format | Article |
| id | doaj-art-2dae00fc8adf43209f990f258f92ed23 |
| institution | Kabale University |
| issn | 1812-156X 2312-6760 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Medical Journal of Babylon |
| spelling | doaj-art-2dae00fc8adf43209f990f258f92ed232025-01-25T10:14:50ZengWolters Kluwer Medknow PublicationsMedical Journal of Babylon1812-156X2312-67602024-01-01211859310.4103/MJBL.MJBL_152_23Evaluation of the inhibitory effect of Gingerol on bacteria and fungi isolated from the vaginaHeba Hadid RashedIbtihal Muiz Al-HussainiAli H. Al-MarzoqiAbstract Background: Gingerol is extracted from the rhizomes of ginger. It showed a clear effect on the bacteria and the Candida isolation from the vagina, and the highest effect was at a concentration of 30 mg/mL. The positive bacteria are more responsive to gingerol than the negative bacteria; gingerol is a great inhibitory activity compared to antibiotics on bacteria. Objectives: The aim of the article is to test the sensitivity of bacteria and Candida to gingerol and some antibiotics. Materials and Methods: In this study, we detected the presence of the phytochemical compounds present in the Zingiber officinale and the process of extraction of gingerol from ginger by HPLC technology, and tested different concentrations of gingerol for their effect on bacteria and fungi isolated from the vagina. Some antibiotics such as (tobramycin and kanamycin) on Staphylococcus aureus and ciprofloxacin and doxycycline on Klebsiella spp. and Escherichia coli and antifungal itraconazole and nystatin on Candida species. Results: Gingerol showed a clear effect on bacteria and Candida isolation from the vagina, and the highest effect was at a concentration of 30 mg/mL. Gram-positive bacteria S. aureus is more sensitive to gingerol than the Gram-negative bacteria E. coli and Klebsiella. Gingerol has a great inhibitory activity compared to antibiotics on bacteria and the highest effect on Candida albicans more than Candida tropicalis and Candida krusei. Conclusion: Through the results, ginger contains many pharaohs and the most important of these is an active compound gingerol that has anti-inflammatory properties through its ability to inhibit the growth of bacteria and Candida and had more impact on microorganisms than antibiotics.https://doi.org/10.4103/MJBL.MJBL_152_23bacteriafungigingerolsusceptibility test |
| spellingShingle | Heba Hadid Rashed Ibtihal Muiz Al-Hussaini Ali H. Al-Marzoqi Evaluation of the inhibitory effect of Gingerol on bacteria and fungi isolated from the vagina Medical Journal of Babylon bacteria fungi gingerol susceptibility test |
| title | Evaluation of the inhibitory effect of Gingerol on bacteria and fungi isolated from the vagina |
| title_full | Evaluation of the inhibitory effect of Gingerol on bacteria and fungi isolated from the vagina |
| title_fullStr | Evaluation of the inhibitory effect of Gingerol on bacteria and fungi isolated from the vagina |
| title_full_unstemmed | Evaluation of the inhibitory effect of Gingerol on bacteria and fungi isolated from the vagina |
| title_short | Evaluation of the inhibitory effect of Gingerol on bacteria and fungi isolated from the vagina |
| title_sort | evaluation of the inhibitory effect of gingerol on bacteria and fungi isolated from the vagina |
| topic | bacteria fungi gingerol susceptibility test |
| url | https://doi.org/10.4103/MJBL.MJBL_152_23 |
| work_keys_str_mv | AT hebahadidrashed evaluationoftheinhibitoryeffectofgingerolonbacteriaandfungiisolatedfromthevagina AT ibtihalmuizalhussaini evaluationoftheinhibitoryeffectofgingerolonbacteriaandfungiisolatedfromthevagina AT alihalmarzoqi evaluationoftheinhibitoryeffectofgingerolonbacteriaandfungiisolatedfromthevagina |