Analysis of the mechanism of Zangjiangzhi capsule in the treatment of hyperlipidemia based on its ingredients identified by UHPLC-Q-Exactive-Orbitrap-MS

Analysis of the mechanism of Zangjiangzhi capsule in the treatment of hyperlipidemia based on its ingredients identified by UHPLC-Q-Exactive-Orbitrap-MS

Objective: To explore the mechanism of action of Zangjiangzhi capsule (ZJZC) in treating hyperlipidemia (HLP). Methods: The components of ZJZC were analyzed and identified using ultra-high performance liquid chromatography with Q-Exactive Orbitrap tandem mass spectrometry (UHPLC-Q-Exactive-Orbitrap-...

Full description

Saved in:

Bibliographic Details
Main Authors:	Changting He, Yuling Zhao, Yongchun Huang, Yudong Su, Shoude Zhang
Format:	Article
Language:	English
Published:	Elsevier 2025-01-01
Series:	Journal of Traditional Chinese Medical Sciences
Subjects:	Zangjiangzhi capsule Hyperlipidemia UHPLC-MS/MS Network pharmacology Molecular docking Enzyme-linked immunosorbent assay
Online Access:	http://www.sciencedirect.com/science/article/pii/S2095754824000991
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Unveiling cellular changes in leukaemia cell lines after cannabidiol treatment through lipidomics
by: David Chamoso-Sanchez, et al.
Published: (2025-01-01)

Pharmacokinetics study of a supersaturatable self-microemulsifying drug delivery system for ellagic acid by UHPLC-Q-TOF-MS
by: Wang Jinglong, et al.
Published: (2021-12-01)

Determination of Saponins in Leaves of Four Swiss Chard ( Beta vulgaris L.) Cultivars by UHPLC-CAD/QTOF-MS/MS
by: Agnieszka Mroczek, et al.
Published: (2021-04-01)

Ripening-dependent changes in antioxidant activities and un-targeted phytochemical fingerprinting of mango (Mangifera Indica L.) cultivar Safaid Chonsa
by: Aniqa, et al.
Published: (2025-01-01)

Effect of Indigenous Non-<i>Saccharomyces</i> Yeasts on Lipid Compositions of Maraština Wine
by: Ana Boban, et al.
Published: (2025-01-01)

Physiological and metabolome characterization of Amaranthus hybridus L. grown under cypermethrin stress: an insight of Jasmonic acid treatment
by: Arun Kumar, et al.
Published: (2025-02-01)

Recovery of Bioactive Constituents from Olive Leaf Pruning Waste of Five Different Cultivars: A Comparison of Green Extraction Techniques to Maximize Health Benefits
by: Hamid Mushtaq, et al.
Published: (2025-01-01)

Systematic identification of the chemical components of leaves and roots of Didymocarpus heucherifolius Hand.-Mazz. based on UHPLC Q-Exactive Orbitrap MS technology coupled with molecular networking strategy
by: Liangyin Shu, et al.
Published: (2025-01-01)

Cell-free supernatants from plant growth-promoting rhizobacteria Bacillus albus strains control Aspergillus flavus disease in peanut and maize seedlings
by: Lai Loi Trinh, et al.
Published: (2025-01-01)

Forced degradation of tacrolimus and the development of a UHPLC method for impurities determination
by: Peterka Tanja Rozman, et al.
Published: (2019-09-01)

The antibacterial and antifungal potential of marine natural ingredients from the symbiont bacteria of mangrove
by: D. Pringgenies, et al.
Published: (2023-10-01)

Pulsed Electric Field Induces Significant Changes in the Metabolome of <i>Fusarium</i> Species and Decreases Their Viability and Toxigenicity
by: Adam Behner, et al.
Published: (2025-01-01)

Effect of in vitro gastrointestinal digestion on the chemical composition and antioxidant properties of Ginkgo biloba leaves decoction and commercial capsules
by: Zhou Yubo, et al.
Published: (2022-12-01)

Antidepressant- and Anxiolytic-like Effects in Mice of Alkaloids from Aerial Parts of <i>Argemone platyceras</i> Link & Otto
by: Mayra Beatriz Gómez-Patiño, et al.
Published: (2025-01-01)

Anti-Hyperlipidemic Effect of Zinc complex of Betulinic acid in High Fat Diet- Induced Hyperlipidemia
by: Mehwish Tayyab, et al.
Published: (2023-04-01)

Automated process assessment of primary healthcare for hyperlipidemia: preliminary findings and implications form Anhui, China
by: Ningjing Yang, et al.
Published: (2025-01-01)

Isoniazid urine spectrophotometry for prediction of serum pharmacokinetics in adults with TB
by: P. S. Rao, et al.
Published: (2024-02-01)

Based on theoretical design simultaneous analysis of multiple neonicotinoid pesticides in beeswax by deep eutectic solvents extraction combined with UHPLC-MS/MS
by: Guodong Mu, et al.
Published: (2025-01-01)

Discovery of novel serum peptide biomarkers for cholangiocarcinoma recurrence through MALDI-TOF MS and LC–MS/MS peptidome analysis
by: Vasin Thanasukarn, et al.
Published: (2025-01-01)

The association between obesity indicators and mortality among individuals with hyperlipidemia: evidence from the NHANES 2003–2018
by: Yiheng Zhang, et al.
Published: (2025-01-01)

Comparison of chemical constituents in Lysimachia species and their antimicrobial activity for extending the shelf life of foods
by: Li-Li Chen, et al.
Published: (2025-01-01)

Identification and pharmacokinetics of saponins in Rhizoma Anemarrhenae after oral administration to rats by HPLC-Q-TOF/MS and HPLC-MS/MS
by: Wang Hai-Qiao, et al.
Published: (2021-12-01)

Environmental Applications of Mass Spectrometry for Emerging Contaminants
by: Anil Kumar Meher, et al.
Published: (2025-01-01)

Network-Based Protein Biomarker Discovery Platforms
by: Minhyung Kim, et al.
Published: (2016-03-01)

UHPLC-UV method validation for simultaneous quantification of vitexin and isovitexin from Santalum album L. leaves
by: Thi Kim Phung Phan, et al.
Published: (2024-06-01)

Characterization of Anthocyanins Including Acetylated Glycosides from Highbush Blueberry (<i>Vaccinium corymbosum</i> L.) Cultivated in Korea Based on UPLC-DAD-QToF/MS and UPLC-Qtrap-MS/MS
by: Ju Hyung Kim, et al.
Published: (2025-01-01)

Comprehensive Metabolomics in Mouse Mast Cell Model of Allergic Rhinitis for Profiling, Modulation, Semiquantitative Analysis, and Pathway Analysis
by: Akshay Suresh Patil, et al.
Published: (2025-01-01)

Metabolomics and Transcriptomics Reveal the Effects of Different Fermentation Times on Antioxidant Activities of <i>Ophiocordyceps sinensis</i>
by: Min He, et al.
Published: (2025-01-01)

The critical role of MLKL in hemorrhagic stroke and the therapeutic potential of its associated protein network
by: Yi Wang, et al.
Published: (2025-01-01)

Association between composite dietary antioxidant index and hyperlipidemia in adults based on the NHANES
by: Kaidi Nie, et al.
Published: (2025-01-01)

Simultaneous Determination of Multiple Acid-Suppressing Drugs by UPLC-MS/MS Method and Application for Pharmacokinetics Study
by: Li X, et al.
Published: (2025-02-01)

Validation of Colchicine Assay Method for Therapeutic Drug Monitoring in Human Plasma
by: Fadime Canbolat
Published: (2022-12-01)

Concurrent Extraction and Analysis of Atmospheric Particulate Matter-bound PBDEs, PAHs, Nitrated PAHs, and OPEs
by: Hsin-Chieh Kung, et al.
Published: (2023-12-01)

Evaluation of Malathion and Malaoxon Contamination in Buffalo and Cow Milk from Afyonkarahisar Region, Turkey, Using Liquid Chromatography/Tandem Mass Spectrometry – a Short Report
by: Kara Recep, et al.
Published: (2016-03-01)

Stability study of thymoquinone, carvacrol and thymol using HPLC-UV and LC-ESI-MS
by: Soliman Rabab M., et al.
Published: (2020-09-01)

Dual-frequency ultrasonic oxidation of cyanobacterial toxins (MC-LR and MC-RR) at drinking water resources: Assessment of analytical methods and ultrasonic reactor configuration
by: Zeynep Eren
Published: (2025-02-01)

A sterol panel for rare lipid disorders: sitosterolemia, cerebrotendinous xanthomatosis and Smith-Lemli-Opitz syndrome
by: Alexander Bauer Westbye, et al.
Published: (2025-01-01)

Proteomic Analysis of the Murine Liver Response to Oral Exposure to Aflatoxin B1 and Ochratoxin A: The Protective Role to Bioactive Compounds
by: Silvia Trombetti, et al.
Published: (2025-01-01)

Elucidation of α-glucosidase inhibitory activity and UHPLC-ESI-QTOF-MS based metabolic profiling of endophytic fungi Alternaria alternata BRN05 isolated from seeds of Swietenia macrophylla king
by: Piyush Kumar, et al.
Published: (2025-01-01)

Characteristics and bioinformatics of peptides from natural and cultured sandfish (Holothuria scabra)
by: Pawitporn Daopa, et al.
Published: (2025-06-01)