XRCC1 R194W and R399Q Polymorphisms and Colorectal Cancer Risk in a Northeastern Mexican Population
Colorectal cancer (CRC) is one of the most common cancers worldwide. Its etiopathogenesis is complex, mainly influenced by genetic instability caused by the accumulation of mutations. The XRCC1 gene, which is involved in DNA repair, has been associated with CRC through the R194W (C194T) and R399Q (G...
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Genetics Research |
| Online Access: | http://dx.doi.org/10.1155/2023/5565646 |
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| author | Juan Pablo Meza-Espinoza Valeria Peralta-Leal Jorge Durán-González Nelly Macías-Gómez Anabel Bocanegra-Alonso Evelia Leal-Ugarte |
| author_facet | Juan Pablo Meza-Espinoza Valeria Peralta-Leal Jorge Durán-González Nelly Macías-Gómez Anabel Bocanegra-Alonso Evelia Leal-Ugarte |
| author_sort | Juan Pablo Meza-Espinoza |
| collection | DOAJ |
| description | Colorectal cancer (CRC) is one of the most common cancers worldwide. Its etiopathogenesis is complex, mainly influenced by genetic instability caused by the accumulation of mutations. The XRCC1 gene, which is involved in DNA repair, has been associated with CRC through the R194W (C194T) and R399Q (G399A) polymorphisms, but the results are inconsistent. Here, we analyzed the association of these polymorphisms with sporadic CRC in a northeastern Mexican population, including 155 male CRC patients and 155 male controls. Genotyping was performed using the RFLP method. An association with CRC was found for the 399A allele (G vs A; OR = 1.48 (1.03–2.13), P=0.034) and for the 399AA genotype in a codominant model (AA vs GG; OR = 3.11 (1.06–9.10), P=0.031). In contrast, there were no significant differences between CRC patients and controls for the C194T polymorphism (C vs T; OR = 0.82 (0.52–1.31), P=0.41). These results are consistent with many similar studies, but further research is needed to verify whether the XRCC1 R194W and R399Q polymorphisms play a role in CRC etiology. The functional significance of these polymorphisms is unclear, but some studies suggest that they influence DNA repair capacity and, thus, cancer risk. |
| format | Article |
| id | doaj-art-2d973d6bbbd946cf8577be13442f5e1e |
| institution | Kabale University |
| issn | 1469-5073 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Genetics Research |
| spelling | doaj-art-2d973d6bbbd946cf8577be13442f5e1e2025-02-03T06:43:10ZengWileyGenetics Research1469-50732023-01-01202310.1155/2023/5565646XRCC1 R194W and R399Q Polymorphisms and Colorectal Cancer Risk in a Northeastern Mexican PopulationJuan Pablo Meza-Espinoza0Valeria Peralta-Leal1Jorge Durán-González2Nelly Macías-Gómez3Anabel Bocanegra-Alonso4Evelia Leal-Ugarte5Facultad de Medicina e Ingeniería en Sistemas Computacionales de MatamorosFacultad de Medicina e Ingeniería en Sistemas Computacionales de MatamorosFacultad de Medicina e Ingeniería en Sistemas Computacionales de MatamorosCentro Universitario del SurUnidad Académica Multidisciplinaria Reynosa-AztlánFacultad de Medicina e Ingeniería en Sistemas Computacionales de MatamorosColorectal cancer (CRC) is one of the most common cancers worldwide. Its etiopathogenesis is complex, mainly influenced by genetic instability caused by the accumulation of mutations. The XRCC1 gene, which is involved in DNA repair, has been associated with CRC through the R194W (C194T) and R399Q (G399A) polymorphisms, but the results are inconsistent. Here, we analyzed the association of these polymorphisms with sporadic CRC in a northeastern Mexican population, including 155 male CRC patients and 155 male controls. Genotyping was performed using the RFLP method. An association with CRC was found for the 399A allele (G vs A; OR = 1.48 (1.03–2.13), P=0.034) and for the 399AA genotype in a codominant model (AA vs GG; OR = 3.11 (1.06–9.10), P=0.031). In contrast, there were no significant differences between CRC patients and controls for the C194T polymorphism (C vs T; OR = 0.82 (0.52–1.31), P=0.41). These results are consistent with many similar studies, but further research is needed to verify whether the XRCC1 R194W and R399Q polymorphisms play a role in CRC etiology. The functional significance of these polymorphisms is unclear, but some studies suggest that they influence DNA repair capacity and, thus, cancer risk.http://dx.doi.org/10.1155/2023/5565646 |
| spellingShingle | Juan Pablo Meza-Espinoza Valeria Peralta-Leal Jorge Durán-González Nelly Macías-Gómez Anabel Bocanegra-Alonso Evelia Leal-Ugarte XRCC1 R194W and R399Q Polymorphisms and Colorectal Cancer Risk in a Northeastern Mexican Population Genetics Research |
| title | XRCC1 R194W and R399Q Polymorphisms and Colorectal Cancer Risk in a Northeastern Mexican Population |
| title_full | XRCC1 R194W and R399Q Polymorphisms and Colorectal Cancer Risk in a Northeastern Mexican Population |
| title_fullStr | XRCC1 R194W and R399Q Polymorphisms and Colorectal Cancer Risk in a Northeastern Mexican Population |
| title_full_unstemmed | XRCC1 R194W and R399Q Polymorphisms and Colorectal Cancer Risk in a Northeastern Mexican Population |
| title_short | XRCC1 R194W and R399Q Polymorphisms and Colorectal Cancer Risk in a Northeastern Mexican Population |
| title_sort | xrcc1 r194w and r399q polymorphisms and colorectal cancer risk in a northeastern mexican population |
| url | http://dx.doi.org/10.1155/2023/5565646 |
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