The role of autophagy in periodontal diseases: a bibliometric analysis from 2006 to 2023
BackgroundPeriodontal disease is a chronic inflammatory condition affecting the supporting structures of the teeth, involving complex interactions between systemic and local immune responses. Autophagy is a tightly regulated cellular process that is responsible for degrading and recycling cellular c...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-05-01
|
| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1493459/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849312328274673664 |
|---|---|
| author | Bitong Zhang Bitong Zhang Yahui Wang Yahui Wang Yahui Wang Haoxiang Chang Haoxiang Chang Chong Wang Chong Wang Hong Fan Hong Fan Xiuyun Ren Xiuyun Ren |
| author_facet | Bitong Zhang Bitong Zhang Yahui Wang Yahui Wang Yahui Wang Haoxiang Chang Haoxiang Chang Chong Wang Chong Wang Hong Fan Hong Fan Xiuyun Ren Xiuyun Ren |
| author_sort | Bitong Zhang |
| collection | DOAJ |
| description | BackgroundPeriodontal disease is a chronic inflammatory condition affecting the supporting structures of the teeth, involving complex interactions between systemic and local immune responses. Autophagy is a tightly regulated cellular process that is responsible for degrading and recycling cellular components, playing a pivotal role in maintaining cellular homeostasis and modulating inflammation in periodontal disease. In recent years, the relationship between these two factors has attracted attention from scholars globally. However, bibliometric analyses in this field are still limited.ObjectivesTo analyze the bibliometric trends and research hotspots related to the role of autophagy in periodontal disease.MethodsArticles and reviews examining the association between periodontal disease and autophagy were retrieved from the Web of Science Core Collection (WOSCC) on 20 June 2024. Bibliometric and knowledge mapping analyses were performed using CiteSpace [6.3. R1 (64-bit) Advanced].ResultsThrough a bibliometric analysis of literature published between 2006 and 2023 on the role of autophagy in periodontal disease, 341 relevant studies were identified. The results indicate a steady annual increase in studies on this topic, with a significant upward trend observed post-2015. Keyword analysis identifies “apoptosis,” “Porphyromonas gingivalis,” “oxidative stress,” “inflammation,” “periodontitis,” “osteogenic differentiation,” “cell death,” and “orthodontic tooth movement” as key research hotspots. Collaboration network analysis identifies China as the leading contributor to research in this field. Document co-citation analysis highlights several influential studies examining the “double-edged sword” role of autophagy in periodontal disease, illustrating how autophagy alleviates oxidative stress and inflammation in periodontitis by removing damaged organelles, inhibiting pro-inflammatory mediators, and promoting periodontal tissue repair through the secretion of pro-angiogenic cytokines. However, excessive autophagy may lead to apoptosis when cellular stress surpasses the repair capacity. This study identifies key trends and research hotspots in autophagy and periodontal disease, underscoring the importance of international collaboration and high-impact journals for advancing the field and guiding future research.ConclusionRecent studies indicate that autophagy has emerged as a critical mediator with dual roles in periodontal disease. Therefore, early control of periodontal inflammation, along with the exploration of how to harness the protective functions of autophagy, may provide future research directions for managing periodontal disease. |
| format | Article |
| id | doaj-art-2d8af4fc7bb345b4b00a35707815c3ff |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-2d8af4fc7bb345b4b00a35707815c3ff2025-08-20T03:53:07ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-05-011210.3389/fmed.2025.14934591493459The role of autophagy in periodontal diseases: a bibliometric analysis from 2006 to 2023Bitong Zhang0Bitong Zhang1Yahui Wang2Yahui Wang3Yahui Wang4Haoxiang Chang5Haoxiang Chang6Chong Wang7Chong Wang8Hong Fan9Hong Fan10Xiuyun Ren11Xiuyun Ren12Shanxi Medical University School and Hospital of Stomatology, Taiyuan, ChinaShanxi Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan, ChinaShanxi Medical University School and Hospital of Stomatology, Taiyuan, ChinaShanxi Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan, ChinaDepartment of Orthodontics, Shanxi Provincial People’s Hospital, The Fifth Clinical Medical College of Shanxi Medical University, Taiyuan, ChinaShanxi Medical University School and Hospital of Stomatology, Taiyuan, ChinaShanxi Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan, ChinaShanxi Medical University School and Hospital of Stomatology, Taiyuan, ChinaShanxi Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan, ChinaShanxi Medical University School and Hospital of Stomatology, Taiyuan, ChinaDepartment of Orthodontics, Shanxi Provincial People’s Hospital, The Fifth Clinical Medical College of Shanxi Medical University, Taiyuan, ChinaShanxi Medical University School and Hospital of Stomatology, Taiyuan, ChinaShanxi Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan, ChinaBackgroundPeriodontal disease is a chronic inflammatory condition affecting the supporting structures of the teeth, involving complex interactions between systemic and local immune responses. Autophagy is a tightly regulated cellular process that is responsible for degrading and recycling cellular components, playing a pivotal role in maintaining cellular homeostasis and modulating inflammation in periodontal disease. In recent years, the relationship between these two factors has attracted attention from scholars globally. However, bibliometric analyses in this field are still limited.ObjectivesTo analyze the bibliometric trends and research hotspots related to the role of autophagy in periodontal disease.MethodsArticles and reviews examining the association between periodontal disease and autophagy were retrieved from the Web of Science Core Collection (WOSCC) on 20 June 2024. Bibliometric and knowledge mapping analyses were performed using CiteSpace [6.3. R1 (64-bit) Advanced].ResultsThrough a bibliometric analysis of literature published between 2006 and 2023 on the role of autophagy in periodontal disease, 341 relevant studies were identified. The results indicate a steady annual increase in studies on this topic, with a significant upward trend observed post-2015. Keyword analysis identifies “apoptosis,” “Porphyromonas gingivalis,” “oxidative stress,” “inflammation,” “periodontitis,” “osteogenic differentiation,” “cell death,” and “orthodontic tooth movement” as key research hotspots. Collaboration network analysis identifies China as the leading contributor to research in this field. Document co-citation analysis highlights several influential studies examining the “double-edged sword” role of autophagy in periodontal disease, illustrating how autophagy alleviates oxidative stress and inflammation in periodontitis by removing damaged organelles, inhibiting pro-inflammatory mediators, and promoting periodontal tissue repair through the secretion of pro-angiogenic cytokines. However, excessive autophagy may lead to apoptosis when cellular stress surpasses the repair capacity. This study identifies key trends and research hotspots in autophagy and periodontal disease, underscoring the importance of international collaboration and high-impact journals for advancing the field and guiding future research.ConclusionRecent studies indicate that autophagy has emerged as a critical mediator with dual roles in periodontal disease. Therefore, early control of periodontal inflammation, along with the exploration of how to harness the protective functions of autophagy, may provide future research directions for managing periodontal disease.https://www.frontiersin.org/articles/10.3389/fmed.2025.1493459/fullperiodontal diseasesautophagybibliometric analysisorthodontic tooth movementperiodontal treatment efficacy |
| spellingShingle | Bitong Zhang Bitong Zhang Yahui Wang Yahui Wang Yahui Wang Haoxiang Chang Haoxiang Chang Chong Wang Chong Wang Hong Fan Hong Fan Xiuyun Ren Xiuyun Ren The role of autophagy in periodontal diseases: a bibliometric analysis from 2006 to 2023 Frontiers in Medicine periodontal diseases autophagy bibliometric analysis orthodontic tooth movement periodontal treatment efficacy |
| title | The role of autophagy in periodontal diseases: a bibliometric analysis from 2006 to 2023 |
| title_full | The role of autophagy in periodontal diseases: a bibliometric analysis from 2006 to 2023 |
| title_fullStr | The role of autophagy in periodontal diseases: a bibliometric analysis from 2006 to 2023 |
| title_full_unstemmed | The role of autophagy in periodontal diseases: a bibliometric analysis from 2006 to 2023 |
| title_short | The role of autophagy in periodontal diseases: a bibliometric analysis from 2006 to 2023 |
| title_sort | role of autophagy in periodontal diseases a bibliometric analysis from 2006 to 2023 |
| topic | periodontal diseases autophagy bibliometric analysis orthodontic tooth movement periodontal treatment efficacy |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1493459/full |
| work_keys_str_mv | AT bitongzhang theroleofautophagyinperiodontaldiseasesabibliometricanalysisfrom2006to2023 AT bitongzhang theroleofautophagyinperiodontaldiseasesabibliometricanalysisfrom2006to2023 AT yahuiwang theroleofautophagyinperiodontaldiseasesabibliometricanalysisfrom2006to2023 AT yahuiwang theroleofautophagyinperiodontaldiseasesabibliometricanalysisfrom2006to2023 AT yahuiwang theroleofautophagyinperiodontaldiseasesabibliometricanalysisfrom2006to2023 AT haoxiangchang theroleofautophagyinperiodontaldiseasesabibliometricanalysisfrom2006to2023 AT haoxiangchang theroleofautophagyinperiodontaldiseasesabibliometricanalysisfrom2006to2023 AT chongwang theroleofautophagyinperiodontaldiseasesabibliometricanalysisfrom2006to2023 AT chongwang theroleofautophagyinperiodontaldiseasesabibliometricanalysisfrom2006to2023 AT hongfan theroleofautophagyinperiodontaldiseasesabibliometricanalysisfrom2006to2023 AT hongfan theroleofautophagyinperiodontaldiseasesabibliometricanalysisfrom2006to2023 AT xiuyunren theroleofautophagyinperiodontaldiseasesabibliometricanalysisfrom2006to2023 AT xiuyunren theroleofautophagyinperiodontaldiseasesabibliometricanalysisfrom2006to2023 AT bitongzhang roleofautophagyinperiodontaldiseasesabibliometricanalysisfrom2006to2023 AT bitongzhang roleofautophagyinperiodontaldiseasesabibliometricanalysisfrom2006to2023 AT yahuiwang roleofautophagyinperiodontaldiseasesabibliometricanalysisfrom2006to2023 AT yahuiwang roleofautophagyinperiodontaldiseasesabibliometricanalysisfrom2006to2023 AT yahuiwang roleofautophagyinperiodontaldiseasesabibliometricanalysisfrom2006to2023 AT haoxiangchang roleofautophagyinperiodontaldiseasesabibliometricanalysisfrom2006to2023 AT haoxiangchang roleofautophagyinperiodontaldiseasesabibliometricanalysisfrom2006to2023 AT chongwang roleofautophagyinperiodontaldiseasesabibliometricanalysisfrom2006to2023 AT chongwang roleofautophagyinperiodontaldiseasesabibliometricanalysisfrom2006to2023 AT hongfan roleofautophagyinperiodontaldiseasesabibliometricanalysisfrom2006to2023 AT hongfan roleofautophagyinperiodontaldiseasesabibliometricanalysisfrom2006to2023 AT xiuyunren roleofautophagyinperiodontaldiseasesabibliometricanalysisfrom2006to2023 AT xiuyunren roleofautophagyinperiodontaldiseasesabibliometricanalysisfrom2006to2023 |