Berberine ameliorates septic cardiomyopathy through protecting mitochondria and upregulating Notch1 signaling in cardiomyocytes

Berberine ameliorates septic cardiomyopathy through protecting mitochondria and upregulating Notch1 signaling in cardiomyocytes

IntroductionSeptic cardiomyopathy (SCM) arises as a consequence of sepsis-associated cardiovascular dysfunction, for which there is currently no specific targeted therapy available. Previous studies have demonstrated the beneficial therapeutic effect of berberine (BBR) on SCM; however, the underlyin...

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Bibliographic Details
Main Authors: Qi Shen, Yufan Yuan, Zelin Li, Ying Ling, Jian Wang, Mingjing Gao, Peng Wang, Mengli Li, Lizhong Lai, Jinlan Jin
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Pharmacology
Subjects:
septic cardiomyopathy
mitochondria
Notch1 signaling pathway
berberine
cardiomyocytes
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1502354/full
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