Berberine attenuates obesity-induced skeletal muscle atrophy via regulation of FUNDC1 in skeletal muscle of mice

Berberine attenuates obesity-induced skeletal muscle atrophy via regulation of FUNDC1 in skeletal muscle of mice

Abstract Skeletal muscle atrophy is a complication of obesity, partially induced by impaired mitophagy. This study investigates whether Berberine(BBR) protects mice from obese skeletal muscle atrophy and the underlying molecular mechanism. Twenty C57BL/6 mice were fed a high-fat diet until they weig...

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Bibliographic Details
Main Authors: Yijie Wu, Yanhui Yang, Caixia Du, Xiaoyue Peng, Wenying Fan, Baocheng Chang, Chunyan Shan
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Obesity-induced skeletal muscle atrophy
Berberine
Mitophagy
FUNDC1
Online Access:https://doi.org/10.1038/s41598-025-89297-2
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