Exosomes as Mediators of Cell-to-Cell Communication in Thyroid Disease
Exosomes are a type of extracellular vehicle, formed by budding cell membranes, containing proteins, DNA, and RNA. Concentrated cargoes from parent cells are enveloped in exosomes, which are cell specific and may have functions in the recipient cell, reflecting a novel physiological and pathological...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2020/4378345 |
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| _version_ | 1832565981022519296 |
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| author | Yi Wang Feng Xu Jia-Yu Zhong Xiao Lin Su-Kang Shan Bei Guo Ming-Hui Zheng Ling-Qing Yuan |
| author_facet | Yi Wang Feng Xu Jia-Yu Zhong Xiao Lin Su-Kang Shan Bei Guo Ming-Hui Zheng Ling-Qing Yuan |
| author_sort | Yi Wang |
| collection | DOAJ |
| description | Exosomes are a type of extracellular vehicle, formed by budding cell membranes, containing proteins, DNA, and RNA. Concentrated cargoes from parent cells are enveloped in exosomes, which are cell specific and may have functions in the recipient cell, reflecting a novel physiological and pathological mechanism in disease development. As a transmitter, exosomes shuttle to different cells or tissues and mediate communications among these organelles. To date, several studies have demonstrated that exosomes play crucial roles in disease pathogenesis and development, such as breast and prostate cancer. However, studies investigating connections between exosomes and thyroid disease are limited. In this review, recent research advances on exosomes in thyroid cancer and Graves’ disease are reviewed. These studies suggest that exosomes are involved in thyroid disease and appear as impressive potentials in thyroid therapeutic areas. |
| format | Article |
| id | doaj-art-2d8695c6c5c1419a988ff26b6c0cccca |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-2d8695c6c5c1419a988ff26b6c0cccca2025-02-03T01:05:29ZengWileyInternational Journal of Endocrinology1687-83371687-83452020-01-01202010.1155/2020/43783454378345Exosomes as Mediators of Cell-to-Cell Communication in Thyroid DiseaseYi Wang0Feng Xu1Jia-Yu Zhong2Xiao Lin3Su-Kang Shan4Bei Guo5Ming-Hui Zheng6Ling-Qing Yuan7Department of Metabolism and Endocrinology, National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Metabolism and Endocrinology, National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Metabolism and Endocrinology, National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Radiology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Metabolism and Endocrinology, National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Metabolism and Endocrinology, National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Metabolism and Endocrinology, National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Metabolism and Endocrinology, National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, ChinaExosomes are a type of extracellular vehicle, formed by budding cell membranes, containing proteins, DNA, and RNA. Concentrated cargoes from parent cells are enveloped in exosomes, which are cell specific and may have functions in the recipient cell, reflecting a novel physiological and pathological mechanism in disease development. As a transmitter, exosomes shuttle to different cells or tissues and mediate communications among these organelles. To date, several studies have demonstrated that exosomes play crucial roles in disease pathogenesis and development, such as breast and prostate cancer. However, studies investigating connections between exosomes and thyroid disease are limited. In this review, recent research advances on exosomes in thyroid cancer and Graves’ disease are reviewed. These studies suggest that exosomes are involved in thyroid disease and appear as impressive potentials in thyroid therapeutic areas.http://dx.doi.org/10.1155/2020/4378345 |
| spellingShingle | Yi Wang Feng Xu Jia-Yu Zhong Xiao Lin Su-Kang Shan Bei Guo Ming-Hui Zheng Ling-Qing Yuan Exosomes as Mediators of Cell-to-Cell Communication in Thyroid Disease International Journal of Endocrinology |
| title | Exosomes as Mediators of Cell-to-Cell Communication in Thyroid Disease |
| title_full | Exosomes as Mediators of Cell-to-Cell Communication in Thyroid Disease |
| title_fullStr | Exosomes as Mediators of Cell-to-Cell Communication in Thyroid Disease |
| title_full_unstemmed | Exosomes as Mediators of Cell-to-Cell Communication in Thyroid Disease |
| title_short | Exosomes as Mediators of Cell-to-Cell Communication in Thyroid Disease |
| title_sort | exosomes as mediators of cell to cell communication in thyroid disease |
| url | http://dx.doi.org/10.1155/2020/4378345 |
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