Inhibition of Germinal Centre Apoptotic Programmes by Epstein-Barr Virus
To establish a persistent latent infection, Epstein-Barr virus (EBV) faces a challenge in that the virus-infected host cell must transit through the germinal centre reaction. This is a site of B cell differentiation where antibody responses are optimised, and the selection criteria for B cells are s...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Advances in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2011/829525 |
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| _version_ | 1832553933537542144 |
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| author | Lindsay C. Spender Gareth J. Inman |
| author_facet | Lindsay C. Spender Gareth J. Inman |
| author_sort | Lindsay C. Spender |
| collection | DOAJ |
| description | To establish a persistent latent infection, Epstein-Barr virus (EBV) faces a challenge in that the virus-infected host cell must transit through the germinal centre reaction. This is a site of B cell differentiation where antibody responses are optimised, and the selection criteria for B cells are stringent. The germinal centre environment is harsh, and the vast majority of B cells here die by apoptosis. Only cells receiving adequate survival signals will differentiate fully to be released into the periphery as long-term memory B cells (the site of persistence). In this review, we detail the apoptotic pathways potentially encountered by EBV-infected B cells during the process of infection, and we describe the functions of those EBV-regulated cellular and viral genes that help promote survival of the host B cell. |
| format | Article |
| id | doaj-art-2d82a477aca44c288c441c360a3d4dd3 |
| institution | Kabale University |
| issn | 1687-9104 1687-9112 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Hematology |
| spelling | doaj-art-2d82a477aca44c288c441c360a3d4dd32025-02-03T05:52:48ZengWileyAdvances in Hematology1687-91041687-91122011-01-01201110.1155/2011/829525829525Inhibition of Germinal Centre Apoptotic Programmes by Epstein-Barr VirusLindsay C. Spender0Gareth J. Inman1Division of Cancer Research, Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UKDivision of Cancer Research, Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UKTo establish a persistent latent infection, Epstein-Barr virus (EBV) faces a challenge in that the virus-infected host cell must transit through the germinal centre reaction. This is a site of B cell differentiation where antibody responses are optimised, and the selection criteria for B cells are stringent. The germinal centre environment is harsh, and the vast majority of B cells here die by apoptosis. Only cells receiving adequate survival signals will differentiate fully to be released into the periphery as long-term memory B cells (the site of persistence). In this review, we detail the apoptotic pathways potentially encountered by EBV-infected B cells during the process of infection, and we describe the functions of those EBV-regulated cellular and viral genes that help promote survival of the host B cell.http://dx.doi.org/10.1155/2011/829525 |
| spellingShingle | Lindsay C. Spender Gareth J. Inman Inhibition of Germinal Centre Apoptotic Programmes by Epstein-Barr Virus Advances in Hematology |
| title | Inhibition of Germinal Centre Apoptotic Programmes by Epstein-Barr Virus |
| title_full | Inhibition of Germinal Centre Apoptotic Programmes by Epstein-Barr Virus |
| title_fullStr | Inhibition of Germinal Centre Apoptotic Programmes by Epstein-Barr Virus |
| title_full_unstemmed | Inhibition of Germinal Centre Apoptotic Programmes by Epstein-Barr Virus |
| title_short | Inhibition of Germinal Centre Apoptotic Programmes by Epstein-Barr Virus |
| title_sort | inhibition of germinal centre apoptotic programmes by epstein barr virus |
| url | http://dx.doi.org/10.1155/2011/829525 |
| work_keys_str_mv | AT lindsaycspender inhibitionofgerminalcentreapoptoticprogrammesbyepsteinbarrvirus AT garethjinman inhibitionofgerminalcentreapoptoticprogrammesbyepsteinbarrvirus |