Safety Evaluation of Artocarpus altilis as Pharmaceutical Agent in Wistar Rats
This study was designed to elucidate the acute toxicity of Artocarpus altilis leaf and bark extracts. In acute toxicity study, no mortality or any toxic reaction was recorded in any group after 14 days of administering the extracts (2000 mg Kg−1 BW). The extracts (ALA, ABA, ALM, and ABM) did not cau...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Toxicology |
| Online Access: | http://dx.doi.org/10.1155/2014/980404 |
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| author | Sudha Sairam Asna Urooj |
| author_facet | Sudha Sairam Asna Urooj |
| author_sort | Sudha Sairam |
| collection | DOAJ |
| description | This study was designed to elucidate the acute toxicity of Artocarpus altilis leaf and bark extracts. In acute toxicity study, no mortality or any toxic reaction was recorded in any group after 14 days of administering the extracts (2000 mg Kg−1 BW). The extracts (ALA, ABA, ALM, and ABM) did not cause any behavioural or physical changes in experimental rats. There was no significant (P≤0.05) difference in the biochemical parameters analysed between the groups. Slight elevation in activities of AST and ALT in extract treated groups was observed, but this did not exert any deleterious effect on the normal metabolism which was supported by the histopathology of liver. Histopathological studies showed no remarkable changes after 14 days of oral administration of ALA, ABA, ALM, and ABM extracts. The study contributes to establishing the nontoxic quality parameters of Artocarpus altilis leaf and bark parts and the results suggest the safety of the extracts in therapeutic uses. |
| format | Article |
| id | doaj-art-2d7fda459aa64448aef70adb6c6080bd |
| institution | Kabale University |
| issn | 1687-8191 1687-8205 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Toxicology |
| spelling | doaj-art-2d7fda459aa64448aef70adb6c6080bd2025-02-03T01:09:10ZengWileyJournal of Toxicology1687-81911687-82052014-01-01201410.1155/2014/980404980404Safety Evaluation of Artocarpus altilis as Pharmaceutical Agent in Wistar RatsSudha Sairam0Asna Urooj1Department of Studies in Food Science and Nutrition, University of Mysore, Mysore 570006, IndiaDepartment of Studies in Food Science and Nutrition, University of Mysore, Mysore 570006, IndiaThis study was designed to elucidate the acute toxicity of Artocarpus altilis leaf and bark extracts. In acute toxicity study, no mortality or any toxic reaction was recorded in any group after 14 days of administering the extracts (2000 mg Kg−1 BW). The extracts (ALA, ABA, ALM, and ABM) did not cause any behavioural or physical changes in experimental rats. There was no significant (P≤0.05) difference in the biochemical parameters analysed between the groups. Slight elevation in activities of AST and ALT in extract treated groups was observed, but this did not exert any deleterious effect on the normal metabolism which was supported by the histopathology of liver. Histopathological studies showed no remarkable changes after 14 days of oral administration of ALA, ABA, ALM, and ABM extracts. The study contributes to establishing the nontoxic quality parameters of Artocarpus altilis leaf and bark parts and the results suggest the safety of the extracts in therapeutic uses.http://dx.doi.org/10.1155/2014/980404 |
| spellingShingle | Sudha Sairam Asna Urooj Safety Evaluation of Artocarpus altilis as Pharmaceutical Agent in Wistar Rats Journal of Toxicology |
| title | Safety Evaluation of Artocarpus altilis as Pharmaceutical Agent in Wistar Rats |
| title_full | Safety Evaluation of Artocarpus altilis as Pharmaceutical Agent in Wistar Rats |
| title_fullStr | Safety Evaluation of Artocarpus altilis as Pharmaceutical Agent in Wistar Rats |
| title_full_unstemmed | Safety Evaluation of Artocarpus altilis as Pharmaceutical Agent in Wistar Rats |
| title_short | Safety Evaluation of Artocarpus altilis as Pharmaceutical Agent in Wistar Rats |
| title_sort | safety evaluation of artocarpus altilis as pharmaceutical agent in wistar rats |
| url | http://dx.doi.org/10.1155/2014/980404 |
| work_keys_str_mv | AT sudhasairam safetyevaluationofartocarpusaltilisaspharmaceuticalagentinwistarrats AT asnaurooj safetyevaluationofartocarpusaltilisaspharmaceuticalagentinwistarrats |