Serum adiponectin levels in patients with rheumatoid arthritis
Background and Objective: Rheumatoid arthritis (RA) is a chronic inflammatory polyarthritis of common occurrence. Adiponectin is an adipocytokine shown to exert anti-inflammatory as well as pro-inflammatory effects. Our objective was to study the serum adiponectin levels in RA and explore its associ...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2019-01-01
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| Series: | Indian Journal of Rheumatology |
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| Online Access: | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2019;volume=14;issue=2;spage=119;epage=122;aulast=Veluri |
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| _version_ | 1832544111440166912 |
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| author | Ganesh Veluri Kiranmayi S Vinapamula P VLN Srinivasa Rao Sirisha Kommireddy Suchitra Musturu Manohar Pullaiah Pasupuleti |
| author_facet | Ganesh Veluri Kiranmayi S Vinapamula P VLN Srinivasa Rao Sirisha Kommireddy Suchitra Musturu Manohar Pullaiah Pasupuleti |
| author_sort | Ganesh Veluri |
| collection | DOAJ |
| description | Background and Objective: Rheumatoid arthritis (RA) is a chronic inflammatory polyarthritis of common occurrence. Adiponectin is an adipocytokine shown to exert anti-inflammatory as well as pro-inflammatory effects. Our objective was to study the serum adiponectin levels in RA and explore its association with RA disease activity.
Materials and Methods: Forty RA patients (newly diagnosed n = 20, RA in clinical remission n = 20) and thirty age-, gender-, and body mass index (BMI)-matched apparently healthy controls were included. Serum adiponectin levels were measured by enzyme-linked immunosorbent assay. RA clinical remission was defined by a Disease Activity Score 28 of <2.6.
Results: Serum adiponectin levels were significantly lower in RA patients compared to controls. Both groups of RA patients had lower adiponectin levels than controls. There was no difference in adiponectin levels between the two groups of RA patients. There was no association of adiponectin with disease activity or BMI.
Conclusions: Serum adiponectin concentration is decreased in RA patients and was not associated with disease activity. |
| format | Article |
| id | doaj-art-2d74dda0a8044c31b547bf9193e19794 |
| institution | Kabale University |
| issn | 0973-3698 0973-3701 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Indian Journal of Rheumatology |
| spelling | doaj-art-2d74dda0a8044c31b547bf9193e197942025-02-03T10:54:59ZengSAGE PublishingIndian Journal of Rheumatology0973-36980973-37012019-01-0114211912210.4103/injr.injr_143_18Serum adiponectin levels in patients with rheumatoid arthritisGanesh VeluriKiranmayi S VinapamulaP VLN Srinivasa RaoSirisha KommireddySuchitra Musturu ManoharPullaiah PasupuletiBackground and Objective: Rheumatoid arthritis (RA) is a chronic inflammatory polyarthritis of common occurrence. Adiponectin is an adipocytokine shown to exert anti-inflammatory as well as pro-inflammatory effects. Our objective was to study the serum adiponectin levels in RA and explore its association with RA disease activity. Materials and Methods: Forty RA patients (newly diagnosed n = 20, RA in clinical remission n = 20) and thirty age-, gender-, and body mass index (BMI)-matched apparently healthy controls were included. Serum adiponectin levels were measured by enzyme-linked immunosorbent assay. RA clinical remission was defined by a Disease Activity Score 28 of <2.6. Results: Serum adiponectin levels were significantly lower in RA patients compared to controls. Both groups of RA patients had lower adiponectin levels than controls. There was no difference in adiponectin levels between the two groups of RA patients. There was no association of adiponectin with disease activity or BMI. Conclusions: Serum adiponectin concentration is decreased in RA patients and was not associated with disease activity.http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2019;volume=14;issue=2;spage=119;epage=122;aulast=VeluriAdiponectindisease activityDisease Activity Score 28inflammationrheumatoid arthritis |
| spellingShingle | Ganesh Veluri Kiranmayi S Vinapamula P VLN Srinivasa Rao Sirisha Kommireddy Suchitra Musturu Manohar Pullaiah Pasupuleti Serum adiponectin levels in patients with rheumatoid arthritis Indian Journal of Rheumatology Adiponectin disease activity Disease Activity Score 28 inflammation rheumatoid arthritis |
| title | Serum adiponectin levels in patients with rheumatoid arthritis |
| title_full | Serum adiponectin levels in patients with rheumatoid arthritis |
| title_fullStr | Serum adiponectin levels in patients with rheumatoid arthritis |
| title_full_unstemmed | Serum adiponectin levels in patients with rheumatoid arthritis |
| title_short | Serum adiponectin levels in patients with rheumatoid arthritis |
| title_sort | serum adiponectin levels in patients with rheumatoid arthritis |
| topic | Adiponectin disease activity Disease Activity Score 28 inflammation rheumatoid arthritis |
| url | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2019;volume=14;issue=2;spage=119;epage=122;aulast=Veluri |
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