The Effect of Probiotics on Gut Microbiota Modulation and Its Role in Mitigating Diabetes-Induced Hepatic Damage in Wistar Rats
The gut microbiota plays a crucial role in regulating health and mitigating diabetes-induced liver injury. This study evaluated the hepatoprotective effects of <i>Bifidobacterium bifidum</i> supplementation, both alone and in combination with metformin, in a rat model of diabetes-induced...
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2025-03-01
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| author | Alaa Talal Qumsani |
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| description | The gut microbiota plays a crucial role in regulating health and mitigating diabetes-induced liver injury. This study evaluated the hepatoprotective effects of <i>Bifidobacterium bifidum</i> supplementation, both alone and in combination with metformin, in a rat model of diabetes-induced liver dysfunction. Rats were divided into six groups: control, probiotic only, metformin only, diabetic, diabetic with probiotic supplementation, and diabetic with combined probiotic and metformin treatment. Diabetes was induced using a single streptozotocin (STZ) injection following a 12 h fast. Probiotic supplementation (1 × 10<sup>9</sup> CFU/kg daily) was initiated 2 weeks before diabetes induction and continued throughout the experiment, while metformin was administered concurrently at a therapeutic dose. Weekly assessments included fasting blood glucose, insulin levels, glycation markers, and liver function tests. Both probiotic and metformin treatments significantly improved glycemic control (<i>p</i> < 0.05) and reduced fasting blood glucose levels (<i>p</i> < 0.01), with the combined therapy demonstrating the most pronounced effects. Additionally, insulin sensitivity was enhanced (<i>p</i> < 0.05), antioxidant enzyme levels were restored (<i>p</i> < 0.01), and histopathological analyses revealed preserved liver architecture, decreased inflammation (<i>p</i> < 0.01), and reduced fibrosis (<i>p</i> < 0.05). The Comet assay confirmed a significant reduction in DNA damage (<i>p</i> < 0.01), indicating the protective effects of the interventions against diabetes-induced hepatic injury. These findings highlight the potential of combining <i>Bifidobacterium bifidum</i> supplementation with metformin as a promising probiotic-based therapeutic approach for managing diabetes-related liver complications. Future studies are warranted to confirm these results and to optimize the long-term efficacy of probiotic interventions in diabetes management. |
| format | Article |
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| spelling | doaj-art-2d70bc0940f042dbbca6f0d4a76cf3e82025-08-20T03:14:25ZengMDPI AGBiology2079-77372025-03-0114432310.3390/biology14040323The Effect of Probiotics on Gut Microbiota Modulation and Its Role in Mitigating Diabetes-Induced Hepatic Damage in Wistar RatsAlaa Talal Qumsani0Biology Department, Al-Jumum University College, Umm Al-Qura University, Makkah 24382, Saudi ArabiaThe gut microbiota plays a crucial role in regulating health and mitigating diabetes-induced liver injury. This study evaluated the hepatoprotective effects of <i>Bifidobacterium bifidum</i> supplementation, both alone and in combination with metformin, in a rat model of diabetes-induced liver dysfunction. Rats were divided into six groups: control, probiotic only, metformin only, diabetic, diabetic with probiotic supplementation, and diabetic with combined probiotic and metformin treatment. Diabetes was induced using a single streptozotocin (STZ) injection following a 12 h fast. Probiotic supplementation (1 × 10<sup>9</sup> CFU/kg daily) was initiated 2 weeks before diabetes induction and continued throughout the experiment, while metformin was administered concurrently at a therapeutic dose. Weekly assessments included fasting blood glucose, insulin levels, glycation markers, and liver function tests. Both probiotic and metformin treatments significantly improved glycemic control (<i>p</i> < 0.05) and reduced fasting blood glucose levels (<i>p</i> < 0.01), with the combined therapy demonstrating the most pronounced effects. Additionally, insulin sensitivity was enhanced (<i>p</i> < 0.05), antioxidant enzyme levels were restored (<i>p</i> < 0.01), and histopathological analyses revealed preserved liver architecture, decreased inflammation (<i>p</i> < 0.01), and reduced fibrosis (<i>p</i> < 0.05). The Comet assay confirmed a significant reduction in DNA damage (<i>p</i> < 0.01), indicating the protective effects of the interventions against diabetes-induced hepatic injury. These findings highlight the potential of combining <i>Bifidobacterium bifidum</i> supplementation with metformin as a promising probiotic-based therapeutic approach for managing diabetes-related liver complications. Future studies are warranted to confirm these results and to optimize the long-term efficacy of probiotic interventions in diabetes management.https://www.mdpi.com/2079-7737/14/4/323gut microbiota modulationprobiotic supplementationmetformindiabetes-induced hepatic dysfunction<i>Bifidobacterium bifidum</i>liver function preservation |
| spellingShingle | Alaa Talal Qumsani The Effect of Probiotics on Gut Microbiota Modulation and Its Role in Mitigating Diabetes-Induced Hepatic Damage in Wistar Rats Biology gut microbiota modulation probiotic supplementation metformin diabetes-induced hepatic dysfunction <i>Bifidobacterium bifidum</i> liver function preservation |
| title | The Effect of Probiotics on Gut Microbiota Modulation and Its Role in Mitigating Diabetes-Induced Hepatic Damage in Wistar Rats |
| title_full | The Effect of Probiotics on Gut Microbiota Modulation and Its Role in Mitigating Diabetes-Induced Hepatic Damage in Wistar Rats |
| title_fullStr | The Effect of Probiotics on Gut Microbiota Modulation and Its Role in Mitigating Diabetes-Induced Hepatic Damage in Wistar Rats |
| title_full_unstemmed | The Effect of Probiotics on Gut Microbiota Modulation and Its Role in Mitigating Diabetes-Induced Hepatic Damage in Wistar Rats |
| title_short | The Effect of Probiotics on Gut Microbiota Modulation and Its Role in Mitigating Diabetes-Induced Hepatic Damage in Wistar Rats |
| title_sort | effect of probiotics on gut microbiota modulation and its role in mitigating diabetes induced hepatic damage in wistar rats |
| topic | gut microbiota modulation probiotic supplementation metformin diabetes-induced hepatic dysfunction <i>Bifidobacterium bifidum</i> liver function preservation |
| url | https://www.mdpi.com/2079-7737/14/4/323 |
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