Familial Aggregation for Ischemic Heart Disease
<strong>Background:</strong> ischemic heart disease is a nosological entity of multifactorial origin with genetic predisposition and susceptible to environmental changes. <br /><strong>Objective:</strong> to determine the existence of familial aggregation for ischemic h...
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Universidad de las Ciencias Médicas de Cienfuegos
2022-09-01
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| Online Access: | https://revfinlay.sld.cu/index.php/finlay/article/view/1165 |
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| author | José Leandro Pérez Guerrero William Arias Salazar |
| author_facet | José Leandro Pérez Guerrero William Arias Salazar |
| author_sort | José Leandro Pérez Guerrero |
| collection | DOAJ |
| description | <strong>Background:</strong> ischemic heart disease is a nosological entity of multifactorial origin with genetic predisposition and susceptible to environmental changes. <br /><strong>Objective:</strong> to determine the existence of familial aggregation for ischemic heart disease in patients seen in the cardiology clinic at the Vladimir Ilich Lenin General Teaching Hospital in Holguín. <br /><strong>Methods:</strong> an analytical observational study of cases and controls (family aggregation study) was carried out. The sample was made up of 60 new patients with a diagnosis of ischemic heart disease (cases) and another 60 patients without a diagnosis of coronary heart disease (controls), paired in a 1:1 ratio. The following variables were used: sex, age, family history of ischemic heart disease and environmental risk factors: smoking, hyperlipidemia, high blood pressure and sedentary lifestyle. The Chi square statistician was used by the Mantel-Haenszel method. The odds ratio (OR) was then calculated to determine the magnitude of association through the ratio of cross products. <br /><strong>Results:</strong> in the case group there was a higher frequency in the family history for ischemic heart disease, being higher for first degree relatives with 31 relatives and 41.3 %. Hyperlipidemia was the most frequent risk factor with 36.7 % in the case group and 37.1 % in the control group. An approximately 4-fold increased risk of suffering from ischemic heart disease was determined in those individuals with a positive first-degree family history, while patients with hyperlipidemia have a 4.8 times greater risk of suffering from ischemic heart disease. <br /><strong>Conclusions:</strong> there is family aggregation for ischemic heart disease and a higher risk of getting sick was shown in patients with a positive family history for the disease, mainly with first-degree relatives and with hyperlipidemia. |
| format | Article |
| id | doaj-art-2d6bd117dc934643a488bae430f137bd |
| institution | Kabale University |
| issn | 2221-2434 |
| language | Spanish |
| publishDate | 2022-09-01 |
| publisher | Universidad de las Ciencias Médicas de Cienfuegos |
| record_format | Article |
| series | Revista Finlay |
| spelling | doaj-art-2d6bd117dc934643a488bae430f137bd2025-01-30T21:22:01ZspaUniversidad de las Ciencias Médicas de CienfuegosRevista Finlay2221-24342022-09-01123314321593Familial Aggregation for Ischemic Heart DiseaseJosé Leandro Pérez Guerrero0William Arias Salazar1Universidad de Ciencias Médicas de Holguín. Hospital General Docente Vladimir Ilich Lenin. Holguín.Universidad de Ciencias Médicas de Holguín. Hospital General Docente Vladimir Ilich Lenin. Holguín.<strong>Background:</strong> ischemic heart disease is a nosological entity of multifactorial origin with genetic predisposition and susceptible to environmental changes. <br /><strong>Objective:</strong> to determine the existence of familial aggregation for ischemic heart disease in patients seen in the cardiology clinic at the Vladimir Ilich Lenin General Teaching Hospital in Holguín. <br /><strong>Methods:</strong> an analytical observational study of cases and controls (family aggregation study) was carried out. The sample was made up of 60 new patients with a diagnosis of ischemic heart disease (cases) and another 60 patients without a diagnosis of coronary heart disease (controls), paired in a 1:1 ratio. The following variables were used: sex, age, family history of ischemic heart disease and environmental risk factors: smoking, hyperlipidemia, high blood pressure and sedentary lifestyle. The Chi square statistician was used by the Mantel-Haenszel method. The odds ratio (OR) was then calculated to determine the magnitude of association through the ratio of cross products. <br /><strong>Results:</strong> in the case group there was a higher frequency in the family history for ischemic heart disease, being higher for first degree relatives with 31 relatives and 41.3 %. Hyperlipidemia was the most frequent risk factor with 36.7 % in the case group and 37.1 % in the control group. An approximately 4-fold increased risk of suffering from ischemic heart disease was determined in those individuals with a positive first-degree family history, while patients with hyperlipidemia have a 4.8 times greater risk of suffering from ischemic heart disease. <br /><strong>Conclusions:</strong> there is family aggregation for ischemic heart disease and a higher risk of getting sick was shown in patients with a positive family history for the disease, mainly with first-degree relatives and with hyperlipidemia.https://revfinlay.sld.cu/index.php/finlay/article/view/1165cardiopatía isquémicafactores de riesgoherencia multifactorialriesgos ambientalesherenciagenes |
| spellingShingle | José Leandro Pérez Guerrero William Arias Salazar Familial Aggregation for Ischemic Heart Disease Revista Finlay cardiopatía isquémica factores de riesgo herencia multifactorial riesgos ambientales herencia genes |
| title | Familial Aggregation for Ischemic Heart Disease |
| title_full | Familial Aggregation for Ischemic Heart Disease |
| title_fullStr | Familial Aggregation for Ischemic Heart Disease |
| title_full_unstemmed | Familial Aggregation for Ischemic Heart Disease |
| title_short | Familial Aggregation for Ischemic Heart Disease |
| title_sort | familial aggregation for ischemic heart disease |
| topic | cardiopatía isquémica factores de riesgo herencia multifactorial riesgos ambientales herencia genes |
| url | https://revfinlay.sld.cu/index.php/finlay/article/view/1165 |
| work_keys_str_mv | AT joseleandroperezguerrero familialaggregationforischemicheartdisease AT williamariassalazar familialaggregationforischemicheartdisease |