Familial Aggregation for Ischemic Heart Disease
<strong>Background:</strong> ischemic heart disease is a nosological entity of multifactorial origin with genetic predisposition and susceptible to environmental changes. <br /><strong>Objective:</strong> to determine the existence of familial aggregation for ischemic h...
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| Main Authors: | , |
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| Format: | Article |
| Language: | Spanish |
| Published: |
Universidad de las Ciencias Médicas de Cienfuegos
2022-09-01
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| Series: | Revista Finlay |
| Subjects: | |
| Online Access: | https://revfinlay.sld.cu/index.php/finlay/article/view/1165 |
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| Summary: | <strong>Background:</strong> ischemic heart disease is a nosological entity of multifactorial origin with genetic predisposition and susceptible to environmental changes. <br /><strong>Objective:</strong> to determine the existence of familial aggregation for ischemic heart disease in patients seen in the cardiology clinic at the Vladimir Ilich Lenin General Teaching Hospital in Holguín. <br /><strong>Methods:</strong> an analytical observational study of cases and controls (family aggregation study) was carried out. The sample was made up of 60 new patients with a diagnosis of ischemic heart disease (cases) and another 60 patients without a diagnosis of coronary heart disease (controls), paired in a 1:1 ratio. The following variables were used: sex, age, family history of ischemic heart disease and environmental risk factors: smoking, hyperlipidemia, high blood pressure and sedentary lifestyle. The Chi square statistician was used by the Mantel-Haenszel method. The odds ratio (OR) was then calculated to determine the magnitude of association through the ratio of cross products. <br /><strong>Results:</strong> in the case group there was a higher frequency in the family history for ischemic heart disease, being higher for first degree relatives with 31 relatives and 41.3 %. Hyperlipidemia was the most frequent risk factor with 36.7 % in the case group and 37.1 % in the control group. An approximately 4-fold increased risk of suffering from ischemic heart disease was determined in those individuals with a positive first-degree family history, while patients with hyperlipidemia have a 4.8 times greater risk of suffering from ischemic heart disease. <br /><strong>Conclusions:</strong> there is family aggregation for ischemic heart disease and a higher risk of getting sick was shown in patients with a positive family history for the disease, mainly with first-degree relatives and with hyperlipidemia. |
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| ISSN: | 2221-2434 |