MTBVAC induces superior antibody titers and IgG avidity compared to BCG vaccination in non-human primates

MTBVAC induces superior antibody titers and IgG avidity compared to BCG vaccination in non-human primates

Abstract The only currently licensed vaccine against tuberculosis (TB), Bacille Calmette Guérin (BCG), is insufficient to control the epidemic. MTBVAC is a live attenuated strain of Mycobacterium tuberculosis (M.tb) and is one the most advanced TB vaccine candidates in the pipeline. It is more effic...

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Main Authors: Marco Polo Peralta-Álvarez, Keya Downward, Andrew White, Hugo Redondo Azema, Laura Sibley, Charlotte Sarfas, Alexandra Morrison, Mike Dennis, Delia Diaz-Santana, Stephanie A. Harris, Shuailin Li, Eugenia Puentes, Nacho Aguilo, Carlos Martin, Sally Sharpe, Helen McShane, Rachel Tanner
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-024-01009-5
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