Inflammation-Related Mechanisms in Chronic Kidney Disease Prediction, Progression, and Outcome
Persistent, low-grade inflammation is now considered a hallmark feature of chronic kidney disease (CKD), being involved in the development of all-cause mortality of these patients. Although substantial improvements have been made in clinical care, CKD remains a major public health burden, affecting...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/2180373 |
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| author | Simona Mihai Elena Codrici Ionela Daniela Popescu Ana-Maria Enciu Lucian Albulescu Laura Georgiana Necula Cristina Mambet Gabriela Anton Cristiana Tanase |
| author_facet | Simona Mihai Elena Codrici Ionela Daniela Popescu Ana-Maria Enciu Lucian Albulescu Laura Georgiana Necula Cristina Mambet Gabriela Anton Cristiana Tanase |
| author_sort | Simona Mihai |
| collection | DOAJ |
| description | Persistent, low-grade inflammation is now considered a hallmark feature of chronic kidney disease (CKD), being involved in the development of all-cause mortality of these patients. Although substantial improvements have been made in clinical care, CKD remains a major public health burden, affecting 10–15% of the population, and its prevalence is constantly growing. Due to its insidious nature, CKD is rarely diagnosed in early stages, and once developed, its progression is unfortunately irreversible. There are many factors that contribute to the setting of the inflammatory status in CKD, including increased production of proinflammatory cytokines, oxidative stress and acidosis, chronic and recurrent infections, altered metabolism of adipose tissue, and last but not least, gut microbiota dysbiosis, an underestimated source of microinflammation. In this scenario, a huge step forward was made by the increasing progression of omics approaches, specially designed for identification of biomarkers useful for early diagnostic and follow-up. Recent omics advances could provide novel insights in deciphering the disease pathophysiology; thus, identification of circulating biomarker panels using state-of-the-art proteomic technologies could improve CKD early diagnosis, monitoring, and prognostics. This review aims to summarize the recent knowledge regarding the relationship between inflammation and CKD, highlighting the current proteomic approaches, as well as the inflammasomes and gut microbiota dysbiosis involvement in the setting of CKD, culminating with the troubling bidirectional connection between CKD and renal malignancy, raised on the background of an inflammatory condition. |
| format | Article |
| id | doaj-art-2d619335db654c52a80cc31b9362c763 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-2d619335db654c52a80cc31b9362c7632025-02-03T01:25:22ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/21803732180373Inflammation-Related Mechanisms in Chronic Kidney Disease Prediction, Progression, and OutcomeSimona Mihai0Elena Codrici1Ionela Daniela Popescu2Ana-Maria Enciu3Lucian Albulescu4Laura Georgiana Necula5Cristina Mambet6Gabriela Anton7Cristiana Tanase8Victor Babes National Institute of Pathology, 050096 Bucharest, RomaniaVictor Babes National Institute of Pathology, 050096 Bucharest, RomaniaVictor Babes National Institute of Pathology, 050096 Bucharest, RomaniaVictor Babes National Institute of Pathology, 050096 Bucharest, RomaniaVictor Babes National Institute of Pathology, 050096 Bucharest, RomaniaVictor Babes National Institute of Pathology, 050096 Bucharest, RomaniaStefan S. Nicolau Institute of Virology, Molecular Virology Department, 030304 Bucharest, RomaniaStefan S. Nicolau Institute of Virology, Molecular Virology Department, 030304 Bucharest, RomaniaVictor Babes National Institute of Pathology, 050096 Bucharest, RomaniaPersistent, low-grade inflammation is now considered a hallmark feature of chronic kidney disease (CKD), being involved in the development of all-cause mortality of these patients. Although substantial improvements have been made in clinical care, CKD remains a major public health burden, affecting 10–15% of the population, and its prevalence is constantly growing. Due to its insidious nature, CKD is rarely diagnosed in early stages, and once developed, its progression is unfortunately irreversible. There are many factors that contribute to the setting of the inflammatory status in CKD, including increased production of proinflammatory cytokines, oxidative stress and acidosis, chronic and recurrent infections, altered metabolism of adipose tissue, and last but not least, gut microbiota dysbiosis, an underestimated source of microinflammation. In this scenario, a huge step forward was made by the increasing progression of omics approaches, specially designed for identification of biomarkers useful for early diagnostic and follow-up. Recent omics advances could provide novel insights in deciphering the disease pathophysiology; thus, identification of circulating biomarker panels using state-of-the-art proteomic technologies could improve CKD early diagnosis, monitoring, and prognostics. This review aims to summarize the recent knowledge regarding the relationship between inflammation and CKD, highlighting the current proteomic approaches, as well as the inflammasomes and gut microbiota dysbiosis involvement in the setting of CKD, culminating with the troubling bidirectional connection between CKD and renal malignancy, raised on the background of an inflammatory condition.http://dx.doi.org/10.1155/2018/2180373 |
| spellingShingle | Simona Mihai Elena Codrici Ionela Daniela Popescu Ana-Maria Enciu Lucian Albulescu Laura Georgiana Necula Cristina Mambet Gabriela Anton Cristiana Tanase Inflammation-Related Mechanisms in Chronic Kidney Disease Prediction, Progression, and Outcome Journal of Immunology Research |
| title | Inflammation-Related Mechanisms in Chronic Kidney Disease Prediction, Progression, and Outcome |
| title_full | Inflammation-Related Mechanisms in Chronic Kidney Disease Prediction, Progression, and Outcome |
| title_fullStr | Inflammation-Related Mechanisms in Chronic Kidney Disease Prediction, Progression, and Outcome |
| title_full_unstemmed | Inflammation-Related Mechanisms in Chronic Kidney Disease Prediction, Progression, and Outcome |
| title_short | Inflammation-Related Mechanisms in Chronic Kidney Disease Prediction, Progression, and Outcome |
| title_sort | inflammation related mechanisms in chronic kidney disease prediction progression and outcome |
| url | http://dx.doi.org/10.1155/2018/2180373 |
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