Novel Arsenic Nanoparticles Are More Effective and Less Toxic than As (III) to Inhibit Extracellular and Intracellular Proliferation of Leishmania donovani
Visceral leishmaniasis, a vector-borne tropical disease that is threatening about 350 million people worldwide, is caused by the protozoan parasite Leishmania donovani. Metalloids like arsenic and antimony have been used to treat diseases like leishmaniasis caused by the kinetoplastid parasites. Ars...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | Journal of Parasitology Research |
| Online Access: | http://dx.doi.org/10.1155/2014/187640 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832563974772621312 |
|---|---|
| author | Sudipta Chakraborty Kaushik Bhar Sandip Saha Rajarshi Chakrabarti Anjali Pal Anirban Siddhanta |
| author_facet | Sudipta Chakraborty Kaushik Bhar Sandip Saha Rajarshi Chakrabarti Anjali Pal Anirban Siddhanta |
| author_sort | Sudipta Chakraborty |
| collection | DOAJ |
| description | Visceral leishmaniasis, a vector-borne tropical disease that is threatening about 350 million people worldwide, is caused by the protozoan parasite Leishmania donovani. Metalloids like arsenic and antimony have been used to treat diseases like leishmaniasis caused by the kinetoplastid parasites. Arsenic (III) at a relatively higher concentration (30 μg/mL) has been shown to have antileishmanial activity, but this concentration is reported to be toxic in several experimental mammalian systems. Nanosized metal (0) particles have been shown to be more effective than their higher oxidation state forms. There is no information so far regarding arsenic nanoparticles (As-NPs) as an antileishmanial agent. We have tested the antileishmanial properties of the As-NPs, developed for the first time in our laboratory. As-NPs inhibited the in vitro growth, oxygen consumption, infectivity, and intramacrophage proliferation of L. donovani parasites at a concentration which is about several fold lower than that of As (III). Moreover, this antileishmanial activity has comparatively less cytotoxic effect on the mouse macrophage cell line. It is evident from our findings that As-NPs have more potential than As (III) to be used as an antileishmanial agent. |
| format | Article |
| id | doaj-art-2d54fe7aba7c4895affa34e695cc4224 |
| institution | Kabale University |
| issn | 2090-0023 2090-0031 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Parasitology Research |
| spelling | doaj-art-2d54fe7aba7c4895affa34e695cc42242025-02-03T01:12:09ZengWileyJournal of Parasitology Research2090-00232090-00312014-01-01201410.1155/2014/187640187640Novel Arsenic Nanoparticles Are More Effective and Less Toxic than As (III) to Inhibit Extracellular and Intracellular Proliferation of Leishmania donovaniSudipta Chakraborty0Kaushik Bhar1Sandip Saha2Rajarshi Chakrabarti3Anjali Pal4Anirban Siddhanta5Department of Biochemistry, University of Calcutta, Kolkata 700019, IndiaDepartment of Biochemistry, University of Calcutta, Kolkata 700019, IndiaDepartment of Civil Engineering, Indian Institute of Technology, Kharagpur 721302, IndiaDepartment of Biochemistry, University of Calcutta, Kolkata 700019, IndiaDepartment of Civil Engineering, Indian Institute of Technology, Kharagpur 721302, IndiaDepartment of Biochemistry, University of Calcutta, Kolkata 700019, IndiaVisceral leishmaniasis, a vector-borne tropical disease that is threatening about 350 million people worldwide, is caused by the protozoan parasite Leishmania donovani. Metalloids like arsenic and antimony have been used to treat diseases like leishmaniasis caused by the kinetoplastid parasites. Arsenic (III) at a relatively higher concentration (30 μg/mL) has been shown to have antileishmanial activity, but this concentration is reported to be toxic in several experimental mammalian systems. Nanosized metal (0) particles have been shown to be more effective than their higher oxidation state forms. There is no information so far regarding arsenic nanoparticles (As-NPs) as an antileishmanial agent. We have tested the antileishmanial properties of the As-NPs, developed for the first time in our laboratory. As-NPs inhibited the in vitro growth, oxygen consumption, infectivity, and intramacrophage proliferation of L. donovani parasites at a concentration which is about several fold lower than that of As (III). Moreover, this antileishmanial activity has comparatively less cytotoxic effect on the mouse macrophage cell line. It is evident from our findings that As-NPs have more potential than As (III) to be used as an antileishmanial agent.http://dx.doi.org/10.1155/2014/187640 |
| spellingShingle | Sudipta Chakraborty Kaushik Bhar Sandip Saha Rajarshi Chakrabarti Anjali Pal Anirban Siddhanta Novel Arsenic Nanoparticles Are More Effective and Less Toxic than As (III) to Inhibit Extracellular and Intracellular Proliferation of Leishmania donovani Journal of Parasitology Research |
| title | Novel Arsenic Nanoparticles Are More Effective and Less Toxic than As (III) to Inhibit Extracellular and Intracellular Proliferation of Leishmania donovani |
| title_full | Novel Arsenic Nanoparticles Are More Effective and Less Toxic than As (III) to Inhibit Extracellular and Intracellular Proliferation of Leishmania donovani |
| title_fullStr | Novel Arsenic Nanoparticles Are More Effective and Less Toxic than As (III) to Inhibit Extracellular and Intracellular Proliferation of Leishmania donovani |
| title_full_unstemmed | Novel Arsenic Nanoparticles Are More Effective and Less Toxic than As (III) to Inhibit Extracellular and Intracellular Proliferation of Leishmania donovani |
| title_short | Novel Arsenic Nanoparticles Are More Effective and Less Toxic than As (III) to Inhibit Extracellular and Intracellular Proliferation of Leishmania donovani |
| title_sort | novel arsenic nanoparticles are more effective and less toxic than as iii to inhibit extracellular and intracellular proliferation of leishmania donovani |
| url | http://dx.doi.org/10.1155/2014/187640 |
| work_keys_str_mv | AT sudiptachakraborty novelarsenicnanoparticlesaremoreeffectiveandlesstoxicthanasiiitoinhibitextracellularandintracellularproliferationofleishmaniadonovani AT kaushikbhar novelarsenicnanoparticlesaremoreeffectiveandlesstoxicthanasiiitoinhibitextracellularandintracellularproliferationofleishmaniadonovani AT sandipsaha novelarsenicnanoparticlesaremoreeffectiveandlesstoxicthanasiiitoinhibitextracellularandintracellularproliferationofleishmaniadonovani AT rajarshichakrabarti novelarsenicnanoparticlesaremoreeffectiveandlesstoxicthanasiiitoinhibitextracellularandintracellularproliferationofleishmaniadonovani AT anjalipal novelarsenicnanoparticlesaremoreeffectiveandlesstoxicthanasiiitoinhibitextracellularandintracellularproliferationofleishmaniadonovani AT anirbansiddhanta novelarsenicnanoparticlesaremoreeffectiveandlesstoxicthanasiiitoinhibitextracellularandintracellularproliferationofleishmaniadonovani |