Impact of Advanced Platelet-Rich Fibrin on Early Bone Healing After Endodontic Microsurgery: A Randomized Controlled Trial
<b>Background:</b> Apical surgery can address periapical pathologies when conventional endodontic treatments fail. Advanced platelet-rich fibrin (A-PRF) has emerged as a regenerative material with the potential to enhance healing in periapical surgery. In this study, we evaluated the eff...
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MDPI AG
2025-02-01
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| author | Aleksandra Karkle Laura Neimane Maksims Zolovs Matiss Dambergs Dita Meistere Anete Vaskevica Anda Slaidina |
| author_facet | Aleksandra Karkle Laura Neimane Maksims Zolovs Matiss Dambergs Dita Meistere Anete Vaskevica Anda Slaidina |
| author_sort | Aleksandra Karkle |
| collection | DOAJ |
| description | <b>Background:</b> Apical surgery can address periapical pathologies when conventional endodontic treatments fail. Advanced platelet-rich fibrin (A-PRF) has emerged as a regenerative material with the potential to enhance healing in periapical surgery. In this study, we evaluated the effect of A-PRF on periapical lesion healing using cone beam computed tomography (CBCT). <b>Methods:</b> A randomized controlled trial at Rīga Stradiņš University Institute of Stomatology included 43 participants (15 males, 28 females; mean age: 44 years) with periradicular lesions. Participants were divided into experimental and control groups. Baseline and follow-up CBCT imaging assessed lesion volumes at 6 and 12 months post-surgery. <b>Results:</b> Mean lesion volumes significantly decreased from 431.4 mm<sup>3</sup> at baseline to 102.8 mm<sup>3</sup> at 6 months and 49.2 mm<sup>3</sup> at 12 months (<i>p</i> < 0.001). A-PRF did not significantly reduce the lesion sizes compared to the controls (<i>p</i> = 0.043), but was associated with reduced inflammation and enhanced soft tissue healing. Key confounders included gender and baseline lesion volume, with males exhibiting smaller lesion sizes postoperatively. <b>Conclusions:</b> The results suggest that A-PRF may not offer a significant advantage in terms of reducing defect size or improving radiographic resolution. |
| format | Article |
| id | doaj-art-2d548ecee4a84e49bdc876eaab5b1ebd |
| institution | DOAJ |
| issn | 2075-4418 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
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| series | Diagnostics |
| spelling | doaj-art-2d548ecee4a84e49bdc876eaab5b1ebd2025-08-20T02:59:14ZengMDPI AGDiagnostics2075-44182025-02-0115551610.3390/diagnostics15050516Impact of Advanced Platelet-Rich Fibrin on Early Bone Healing After Endodontic Microsurgery: A Randomized Controlled TrialAleksandra Karkle0Laura Neimane1Maksims Zolovs2Matiss Dambergs3Dita Meistere4Anete Vaskevica5Anda Slaidina6Department of Conservative Dentistry and Oral Health, Riga Stradins University, LV-1007 Riga, LatviaDepartment of Conservative Dentistry and Oral Health, Riga Stradins University, LV-1007 Riga, LatviaStatistics Unit, Riga Stradins University, LV-1007 Riga, LatviaRSU Institute of Stomatology, LV-1007 Riga, LatviaDepartment of Conservative Dentistry and Oral Health, Riga Stradins University, LV-1007 Riga, LatviaDepartment of Conservative Dentistry and Oral Health, Riga Stradins University, LV-1007 Riga, LatviaRSU Institute of Stomatology, LV-1007 Riga, Latvia<b>Background:</b> Apical surgery can address periapical pathologies when conventional endodontic treatments fail. Advanced platelet-rich fibrin (A-PRF) has emerged as a regenerative material with the potential to enhance healing in periapical surgery. In this study, we evaluated the effect of A-PRF on periapical lesion healing using cone beam computed tomography (CBCT). <b>Methods:</b> A randomized controlled trial at Rīga Stradiņš University Institute of Stomatology included 43 participants (15 males, 28 females; mean age: 44 years) with periradicular lesions. Participants were divided into experimental and control groups. Baseline and follow-up CBCT imaging assessed lesion volumes at 6 and 12 months post-surgery. <b>Results:</b> Mean lesion volumes significantly decreased from 431.4 mm<sup>3</sup> at baseline to 102.8 mm<sup>3</sup> at 6 months and 49.2 mm<sup>3</sup> at 12 months (<i>p</i> < 0.001). A-PRF did not significantly reduce the lesion sizes compared to the controls (<i>p</i> = 0.043), but was associated with reduced inflammation and enhanced soft tissue healing. Key confounders included gender and baseline lesion volume, with males exhibiting smaller lesion sizes postoperatively. <b>Conclusions:</b> The results suggest that A-PRF may not offer a significant advantage in terms of reducing defect size or improving radiographic resolution.https://www.mdpi.com/2075-4418/15/5/516apical surgeryadvanced platelet-rich fibrinbone regenerationCBCT |
| spellingShingle | Aleksandra Karkle Laura Neimane Maksims Zolovs Matiss Dambergs Dita Meistere Anete Vaskevica Anda Slaidina Impact of Advanced Platelet-Rich Fibrin on Early Bone Healing After Endodontic Microsurgery: A Randomized Controlled Trial Diagnostics apical surgery advanced platelet-rich fibrin bone regeneration CBCT |
| title | Impact of Advanced Platelet-Rich Fibrin on Early Bone Healing After Endodontic Microsurgery: A Randomized Controlled Trial |
| title_full | Impact of Advanced Platelet-Rich Fibrin on Early Bone Healing After Endodontic Microsurgery: A Randomized Controlled Trial |
| title_fullStr | Impact of Advanced Platelet-Rich Fibrin on Early Bone Healing After Endodontic Microsurgery: A Randomized Controlled Trial |
| title_full_unstemmed | Impact of Advanced Platelet-Rich Fibrin on Early Bone Healing After Endodontic Microsurgery: A Randomized Controlled Trial |
| title_short | Impact of Advanced Platelet-Rich Fibrin on Early Bone Healing After Endodontic Microsurgery: A Randomized Controlled Trial |
| title_sort | impact of advanced platelet rich fibrin on early bone healing after endodontic microsurgery a randomized controlled trial |
| topic | apical surgery advanced platelet-rich fibrin bone regeneration CBCT |
| url | https://www.mdpi.com/2075-4418/15/5/516 |
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