Extradigestive Manifestation of Helicobacter Pylori Infection in Children and Adolescents

Helicobacter pylori infection fulfills each of Koch's postulates as a human pathogen causing chronic active gastritis. Disease consequences that develop in a subset of infected subjects include peptic ulcerations, gastric adenocarcinoma and mucosa-associated lymphoid tissue lymphoma. More recen...

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Main Authors: Philip M Sherman, Frank YH Lin
Format: Article
Language:English
Published: Wiley 2005-01-01
Series:Canadian Journal of Gastroenterology
Online Access:http://dx.doi.org/10.1155/2005/971974
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author Philip M Sherman
Frank YH Lin
author_facet Philip M Sherman
Frank YH Lin
author_sort Philip M Sherman
collection DOAJ
description Helicobacter pylori infection fulfills each of Koch's postulates as a human pathogen causing chronic active gastritis. Disease consequences that develop in a subset of infected subjects include peptic ulcerations, gastric adenocarcinoma and mucosa-associated lymphoid tissue lymphoma. More recently, multiple publications have advocated a role for H pylori infection in causing a variety of extraintestinal manifestations. Many of these reports suffer from being case reports or case series without adequate controls. As a result, purported manifestations may simply be coincidental in nature. On the other hand, increasing evidence supports H pylori infection as a cause of sideropenic (refractory iron deficiency) anemia. Moderate evidence supports H pylori gastric infection as a cause of some cases of immune thrombocytopenic purpura due to molecular mimicry. Guidelines should be adjusted in accordance with advancing knowledge in the field.
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series Canadian Journal of Gastroenterology
spelling doaj-art-2d4b6c07a3934e30bd6817c0f6ad70552025-02-03T01:09:09ZengWileyCanadian Journal of Gastroenterology0835-79002005-01-0119742142410.1155/2005/971974Extradigestive Manifestation of Helicobacter Pylori Infection in Children and AdolescentsPhilip M Sherman0Frank YH Lin1Research Institute, Hospital for Sick Children, University of Toronto, Toronto, Ontario, CanadaResearch Institute, Hospital for Sick Children, University of Toronto, Toronto, Ontario, CanadaHelicobacter pylori infection fulfills each of Koch's postulates as a human pathogen causing chronic active gastritis. Disease consequences that develop in a subset of infected subjects include peptic ulcerations, gastric adenocarcinoma and mucosa-associated lymphoid tissue lymphoma. More recently, multiple publications have advocated a role for H pylori infection in causing a variety of extraintestinal manifestations. Many of these reports suffer from being case reports or case series without adequate controls. As a result, purported manifestations may simply be coincidental in nature. On the other hand, increasing evidence supports H pylori infection as a cause of sideropenic (refractory iron deficiency) anemia. Moderate evidence supports H pylori gastric infection as a cause of some cases of immune thrombocytopenic purpura due to molecular mimicry. Guidelines should be adjusted in accordance with advancing knowledge in the field.http://dx.doi.org/10.1155/2005/971974
spellingShingle Philip M Sherman
Frank YH Lin
Extradigestive Manifestation of Helicobacter Pylori Infection in Children and Adolescents
Canadian Journal of Gastroenterology
title Extradigestive Manifestation of Helicobacter Pylori Infection in Children and Adolescents
title_full Extradigestive Manifestation of Helicobacter Pylori Infection in Children and Adolescents
title_fullStr Extradigestive Manifestation of Helicobacter Pylori Infection in Children and Adolescents
title_full_unstemmed Extradigestive Manifestation of Helicobacter Pylori Infection in Children and Adolescents
title_short Extradigestive Manifestation of Helicobacter Pylori Infection in Children and Adolescents
title_sort extradigestive manifestation of helicobacter pylori infection in children and adolescents
url http://dx.doi.org/10.1155/2005/971974
work_keys_str_mv AT philipmsherman extradigestivemanifestationofhelicobacterpyloriinfectioninchildrenandadolescents
AT frankyhlin extradigestivemanifestationofhelicobacterpyloriinfectioninchildrenandadolescents