Association between BDNF rs6265 and Obesity in the Boston Puerto Rican Health Study
Brain-derived neurotrophic factor (BDNF) has been associated with regulation of body weight and appetite. The goal of this study was to examine the interactions of a functional variant (rs6265) in the BDNF gene with dietary intake for obesity traits in the Boston Puerto Rican Health Study. BDNF rs62...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2012/102942 |
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| author | Xian-Yong Ma Wei Qiao Qiu Caren E. Smith Laurence D. Parnell Zong-Yong Jiang Jose M. Ordovas Katherine L. Tucker Chao-Qiang Lai |
| author_facet | Xian-Yong Ma Wei Qiao Qiu Caren E. Smith Laurence D. Parnell Zong-Yong Jiang Jose M. Ordovas Katherine L. Tucker Chao-Qiang Lai |
| author_sort | Xian-Yong Ma |
| collection | DOAJ |
| description | Brain-derived neurotrophic factor (BDNF) has been associated with regulation of body weight and appetite. The goal of this study was to examine the interactions of a functional variant (rs6265) in the BDNF gene with dietary intake for obesity traits in the Boston Puerto Rican Health Study. BDNF rs6265 was genotyped in 1147 Puerto Rican adults and examined for association with obesity-related traits. Men (n=242) with the GG genotype had higher BMI (P=0.009), waist circumference (P=0.002), hip (P=0.002), and weight (P=0.03) than GA or AA carriers (n=94). They had twice the risk of being overweight (BMI≥25) relative to GA or AA carriers (OR = 2.08, CI = 1.02–4.23, and P=0.043). Interactions between rs6265 and polyunsaturated fatty acids (PUFA) intake were associated with BMI, hip, and weight, and n-3 : n-6 PUFA ratio with waist circumference in men. In contrast, women (n=595) with the GG genotype had significantly lower BMI (P=0.009), hip (P=0.029), and weight (P=0.027) than GA or AA carriers (n=216). Women with the GG genotype were 50% less likely to be overweight compared to GA or AA carriers (OR = 0.05, CI = 0.27–0.91, and P=0.024). In summary, BDNF rs6265 is differentially associated with obesity risk by sex and interacts with PUFA intake influencing obesity traits in Boston Puerto Rican men. |
| format | Article |
| id | doaj-art-2d4012e82094473090022ab212520f46 |
| institution | Kabale University |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-2d4012e82094473090022ab212520f462025-02-03T01:02:45ZengWileyJournal of Obesity2090-07082090-07162012-01-01201210.1155/2012/102942102942Association between BDNF rs6265 and Obesity in the Boston Puerto Rican Health StudyXian-Yong Ma0Wei Qiao Qiu1Caren E. Smith2Laurence D. Parnell3Zong-Yong Jiang4Jose M. Ordovas5Katherine L. Tucker6Chao-Qiang Lai7Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, ChinaAlzheimer’s Disease Center at Boston university, Boston, MA 02215, USANutrition and Genomics Laboratory, JM-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USANutrition and Genomics Laboratory, JM-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USAInstitute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, ChinaNutrition and Genomics Laboratory, JM-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USADepartment of Health Sciences, Northeastern University, Boston, MA 02115, USANutrition and Genomics Laboratory, JM-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USABrain-derived neurotrophic factor (BDNF) has been associated with regulation of body weight and appetite. The goal of this study was to examine the interactions of a functional variant (rs6265) in the BDNF gene with dietary intake for obesity traits in the Boston Puerto Rican Health Study. BDNF rs6265 was genotyped in 1147 Puerto Rican adults and examined for association with obesity-related traits. Men (n=242) with the GG genotype had higher BMI (P=0.009), waist circumference (P=0.002), hip (P=0.002), and weight (P=0.03) than GA or AA carriers (n=94). They had twice the risk of being overweight (BMI≥25) relative to GA or AA carriers (OR = 2.08, CI = 1.02–4.23, and P=0.043). Interactions between rs6265 and polyunsaturated fatty acids (PUFA) intake were associated with BMI, hip, and weight, and n-3 : n-6 PUFA ratio with waist circumference in men. In contrast, women (n=595) with the GG genotype had significantly lower BMI (P=0.009), hip (P=0.029), and weight (P=0.027) than GA or AA carriers (n=216). Women with the GG genotype were 50% less likely to be overweight compared to GA or AA carriers (OR = 0.05, CI = 0.27–0.91, and P=0.024). In summary, BDNF rs6265 is differentially associated with obesity risk by sex and interacts with PUFA intake influencing obesity traits in Boston Puerto Rican men.http://dx.doi.org/10.1155/2012/102942 |
| spellingShingle | Xian-Yong Ma Wei Qiao Qiu Caren E. Smith Laurence D. Parnell Zong-Yong Jiang Jose M. Ordovas Katherine L. Tucker Chao-Qiang Lai Association between BDNF rs6265 and Obesity in the Boston Puerto Rican Health Study Journal of Obesity |
| title | Association between BDNF rs6265 and Obesity in the Boston Puerto Rican Health Study |
| title_full | Association between BDNF rs6265 and Obesity in the Boston Puerto Rican Health Study |
| title_fullStr | Association between BDNF rs6265 and Obesity in the Boston Puerto Rican Health Study |
| title_full_unstemmed | Association between BDNF rs6265 and Obesity in the Boston Puerto Rican Health Study |
| title_short | Association between BDNF rs6265 and Obesity in the Boston Puerto Rican Health Study |
| title_sort | association between bdnf rs6265 and obesity in the boston puerto rican health study |
| url | http://dx.doi.org/10.1155/2012/102942 |
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