The epidermal lipid-microbiome loop and immunity: Important players in atopic dermatitis
Background: The promotion of epidermal barrier dysfunction is attributed to abnormalities in the lipid-microbiome positive feedback loop which significantly influences the imbalance of the epithelial immune microenvironment (EIME) in atopic dermatitis (AD). This imbalance encompasses impaired lamell...
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Elsevier
2025-02-01
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| Series: | Journal of Advanced Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2090123224000882 |
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| author | Junchao Wu Lisha Li Tingrui Zhang Jiaye Lu Zongguang Tai Quangang Zhu Zhongjian Chen |
| author_facet | Junchao Wu Lisha Li Tingrui Zhang Jiaye Lu Zongguang Tai Quangang Zhu Zhongjian Chen |
| author_sort | Junchao Wu |
| collection | DOAJ |
| description | Background: The promotion of epidermal barrier dysfunction is attributed to abnormalities in the lipid-microbiome positive feedback loop which significantly influences the imbalance of the epithelial immune microenvironment (EIME) in atopic dermatitis (AD). This imbalance encompasses impaired lamellar membrane integrity, heightened exposure to epidermal pathogens, and the regulation of innate and adaptive immunity. The lipid-microbiome loop is substantially influenced by intense adaptive immunity which is triggered by abnormal loop activity and affects the loop's integrity through the induction of atypical lipid composition and responses to dysregulated epidermal microbes. Immune responses participate in lipid abnormalities within the EIME by downregulating barrier gene expression and are further cascade-amplified by microbial dysregulation which is instigated by barrier impairment. Aim of review: This review examines the relationship between abnormal lipid composition, microbiome disturbances, and immune responses in AD while progressively substantiating the crosstalk mechanism among these factors. Based on this analysis, the “lipid-microbiome” positive feedback loop, regulated by immune responses, is proposed. Key scientific concepts of review: The review delves into the impact of adaptive immune responses that regulate the EIME, driving AD, and investigates potential mechanisms by which lipid supplementation and probiotics may alleviate AD through the up-regulation of the epidermal barrier and modulation of immune signaling. This exploration offers support for targeting the EIME to attenuate AD. |
| format | Article |
| id | doaj-art-2d3e9c81a78b42c1ad0ebbcbdd5d4eb6 |
| institution | Kabale University |
| issn | 2090-1232 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Advanced Research |
| spelling | doaj-art-2d3e9c81a78b42c1ad0ebbcbdd5d4eb62025-01-18T05:04:22ZengElsevierJournal of Advanced Research2090-12322025-02-0168359374The epidermal lipid-microbiome loop and immunity: Important players in atopic dermatitisJunchao Wu0Lisha Li1Tingrui Zhang2Jiaye Lu3Zongguang Tai4Quangang Zhu5Zhongjian Chen6School of Medicine, Shanghai University, Shanghai 200444, China; Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, 200443, ChinaSchool of Medicine, Shanghai University, Shanghai 200444, China; Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, 200443, ChinaSchool of Medicine, Shanghai University, Shanghai 200444, China; Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, 200443, ChinaSchool of Medicine, Shanghai University, Shanghai 200444, China; Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, 200443, ChinaShanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, 200443, China; Shanghai Engineering Research Center for Topical Chinese Medicine, Shanghai, 200443, China; Corresponding authors.Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, 200443, China; Shanghai Engineering Research Center for Topical Chinese Medicine, Shanghai, 200443, China; Corresponding authors.School of Medicine, Shanghai University, Shanghai 200444, China; Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, 200443, China; Shanghai Engineering Research Center for Topical Chinese Medicine, Shanghai, 200443, China; Corresponding authors.Background: The promotion of epidermal barrier dysfunction is attributed to abnormalities in the lipid-microbiome positive feedback loop which significantly influences the imbalance of the epithelial immune microenvironment (EIME) in atopic dermatitis (AD). This imbalance encompasses impaired lamellar membrane integrity, heightened exposure to epidermal pathogens, and the regulation of innate and adaptive immunity. The lipid-microbiome loop is substantially influenced by intense adaptive immunity which is triggered by abnormal loop activity and affects the loop's integrity through the induction of atypical lipid composition and responses to dysregulated epidermal microbes. Immune responses participate in lipid abnormalities within the EIME by downregulating barrier gene expression and are further cascade-amplified by microbial dysregulation which is instigated by barrier impairment. Aim of review: This review examines the relationship between abnormal lipid composition, microbiome disturbances, and immune responses in AD while progressively substantiating the crosstalk mechanism among these factors. Based on this analysis, the “lipid-microbiome” positive feedback loop, regulated by immune responses, is proposed. Key scientific concepts of review: The review delves into the impact of adaptive immune responses that regulate the EIME, driving AD, and investigates potential mechanisms by which lipid supplementation and probiotics may alleviate AD through the up-regulation of the epidermal barrier and modulation of immune signaling. This exploration offers support for targeting the EIME to attenuate AD.http://www.sciencedirect.com/science/article/pii/S2090123224000882Atopic dermatitisLipid-microbiome loopAdaptive immunityEpidermal lipidMicrobe |
| spellingShingle | Junchao Wu Lisha Li Tingrui Zhang Jiaye Lu Zongguang Tai Quangang Zhu Zhongjian Chen The epidermal lipid-microbiome loop and immunity: Important players in atopic dermatitis Journal of Advanced Research Atopic dermatitis Lipid-microbiome loop Adaptive immunity Epidermal lipid Microbe |
| title | The epidermal lipid-microbiome loop and immunity: Important players in atopic dermatitis |
| title_full | The epidermal lipid-microbiome loop and immunity: Important players in atopic dermatitis |
| title_fullStr | The epidermal lipid-microbiome loop and immunity: Important players in atopic dermatitis |
| title_full_unstemmed | The epidermal lipid-microbiome loop and immunity: Important players in atopic dermatitis |
| title_short | The epidermal lipid-microbiome loop and immunity: Important players in atopic dermatitis |
| title_sort | epidermal lipid microbiome loop and immunity important players in atopic dermatitis |
| topic | Atopic dermatitis Lipid-microbiome loop Adaptive immunity Epidermal lipid Microbe |
| url | http://www.sciencedirect.com/science/article/pii/S2090123224000882 |
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