Current Status of Alginate in Drug Delivery
Alginate is one of the natural polymers that are often used in drug- and protein-delivery systems. The use of alginate can provide several advantages including ease of preparation, biocompatibility, biodegradability, and nontoxicity. It can be applied to various routes of drug administration includi...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Advances in Pharmacological and Pharmaceutical Sciences |
| Online Access: | http://dx.doi.org/10.1155/2020/8886095 |
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| author | Dewi Melani Hariyadi Nazrul Islam |
| author_facet | Dewi Melani Hariyadi Nazrul Islam |
| author_sort | Dewi Melani Hariyadi |
| collection | DOAJ |
| description | Alginate is one of the natural polymers that are often used in drug- and protein-delivery systems. The use of alginate can provide several advantages including ease of preparation, biocompatibility, biodegradability, and nontoxicity. It can be applied to various routes of drug administration including targeted or localized drug-delivery systems. The development of alginates as a selected polymer in various delivery systems can be adjusted depending on the challenges that must be overcome by drug or proteins or the system itself. The increased effectiveness and safety of sodium alginate in the drug- or protein-delivery system are evidenced by changing the physicochemical characteristics of the drug or proteins. In this review, various routes of alginate-based drug or protein delivery, the effectivity of alginate in the stem cells, and cell encapsulation have been discussed. The recent advances in the in vivo alginate-based drug-delivery systems as well as their toxicities have also been reviewed. |
| format | Article |
| id | doaj-art-2d3de7684df84c3b92be69b8dfad3340 |
| institution | Kabale University |
| issn | 2633-4690 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Pharmacological and Pharmaceutical Sciences |
| spelling | doaj-art-2d3de7684df84c3b92be69b8dfad33402025-02-03T05:49:54ZengWileyAdvances in Pharmacological and Pharmaceutical Sciences2633-46902020-01-01202010.1155/2020/88860958886095Current Status of Alginate in Drug DeliveryDewi Melani Hariyadi0Nazrul Islam1Pharmaceutics Department, Faculty of Pharmacy, Airlangga University, Nanizar Zaman Joenoes Building, Jl. Mulyorejo Campus C, Surabaya 60115, IndonesiaSchool of Clinical Sciences, Queensland University of Technology, Brisbane, AustraliaAlginate is one of the natural polymers that are often used in drug- and protein-delivery systems. The use of alginate can provide several advantages including ease of preparation, biocompatibility, biodegradability, and nontoxicity. It can be applied to various routes of drug administration including targeted or localized drug-delivery systems. The development of alginates as a selected polymer in various delivery systems can be adjusted depending on the challenges that must be overcome by drug or proteins or the system itself. The increased effectiveness and safety of sodium alginate in the drug- or protein-delivery system are evidenced by changing the physicochemical characteristics of the drug or proteins. In this review, various routes of alginate-based drug or protein delivery, the effectivity of alginate in the stem cells, and cell encapsulation have been discussed. The recent advances in the in vivo alginate-based drug-delivery systems as well as their toxicities have also been reviewed.http://dx.doi.org/10.1155/2020/8886095 |
| spellingShingle | Dewi Melani Hariyadi Nazrul Islam Current Status of Alginate in Drug Delivery Advances in Pharmacological and Pharmaceutical Sciences |
| title | Current Status of Alginate in Drug Delivery |
| title_full | Current Status of Alginate in Drug Delivery |
| title_fullStr | Current Status of Alginate in Drug Delivery |
| title_full_unstemmed | Current Status of Alginate in Drug Delivery |
| title_short | Current Status of Alginate in Drug Delivery |
| title_sort | current status of alginate in drug delivery |
| url | http://dx.doi.org/10.1155/2020/8886095 |
| work_keys_str_mv | AT dewimelanihariyadi currentstatusofalginateindrugdelivery AT nazrulislam currentstatusofalginateindrugdelivery |