Current Hypotheses on How Microsatellite Instability Leads to Enhanced Survival of Lynch Syndrome Patients
High levels of microsatellite instability (MSI-high) are a cardinal feature of colorectal tumors from patients with Lynch Syndrome. Other key characteristics of Lynch Syndrome are that these patients experience fewer metastases and have enhanced survival when compared to patients diagnosed with micr...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2010/170432 |
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| author | Kristen M. Drescher Poonam Sharma Henry T. Lynch |
| author_facet | Kristen M. Drescher Poonam Sharma Henry T. Lynch |
| author_sort | Kristen M. Drescher |
| collection | DOAJ |
| description | High levels of microsatellite instability (MSI-high) are a cardinal feature of colorectal tumors from patients with Lynch Syndrome. Other key characteristics of Lynch Syndrome are that these patients experience fewer metastases and have enhanced survival when compared to patients diagnosed with microsatellite stable (MSS) colorectal cancer. Many of the characteristics associated with Lynch Syndrome including enhanced survival are also observed in patients with sporadic MSI-high colorectal cancer. In this review we will present the current state of knowledge regarding the mechanisms that are utilized by the host to control colorectal cancer in Lynch Syndrome and why these same mechanisms fail in MSS colorectal cancers. |
| format | Article |
| id | doaj-art-2d336995cf374c3f968822707c533e34 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-2d336995cf374c3f968822707c533e342025-02-03T06:00:22ZengWileyClinical and Developmental Immunology1740-25221740-25302010-01-01201010.1155/2010/170432170432Current Hypotheses on How Microsatellite Instability Leads to Enhanced Survival of Lynch Syndrome PatientsKristen M. Drescher0Poonam Sharma1Henry T. Lynch2Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE 68178, USADepartment of Pathology, Creighton University School of Medicine, Omaha, NE 68178, USADepartment of Preventative Medicine, Creighton University School of Medicine, Omaha, NE 68178, USAHigh levels of microsatellite instability (MSI-high) are a cardinal feature of colorectal tumors from patients with Lynch Syndrome. Other key characteristics of Lynch Syndrome are that these patients experience fewer metastases and have enhanced survival when compared to patients diagnosed with microsatellite stable (MSS) colorectal cancer. Many of the characteristics associated with Lynch Syndrome including enhanced survival are also observed in patients with sporadic MSI-high colorectal cancer. In this review we will present the current state of knowledge regarding the mechanisms that are utilized by the host to control colorectal cancer in Lynch Syndrome and why these same mechanisms fail in MSS colorectal cancers.http://dx.doi.org/10.1155/2010/170432 |
| spellingShingle | Kristen M. Drescher Poonam Sharma Henry T. Lynch Current Hypotheses on How Microsatellite Instability Leads to Enhanced Survival of Lynch Syndrome Patients Clinical and Developmental Immunology |
| title | Current Hypotheses on How Microsatellite Instability Leads to Enhanced Survival of Lynch Syndrome Patients |
| title_full | Current Hypotheses on How Microsatellite Instability Leads to Enhanced Survival of Lynch Syndrome Patients |
| title_fullStr | Current Hypotheses on How Microsatellite Instability Leads to Enhanced Survival of Lynch Syndrome Patients |
| title_full_unstemmed | Current Hypotheses on How Microsatellite Instability Leads to Enhanced Survival of Lynch Syndrome Patients |
| title_short | Current Hypotheses on How Microsatellite Instability Leads to Enhanced Survival of Lynch Syndrome Patients |
| title_sort | current hypotheses on how microsatellite instability leads to enhanced survival of lynch syndrome patients |
| url | http://dx.doi.org/10.1155/2010/170432 |
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