Application of Proteomics to Inflammatory Bowel Disease Research: Current Status and Future Perspectives
Inflammatory bowel disease (IBD) is a chronic relapsing/remitting inflammatory illness of the gastrointestinal tract of unknown aetiology. Despite recent advances in decoding the pathophysiology of IBD, many questions regarding disease pathogenesis remain. Genome-wide association studies (GWAS) and...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2019/1426954 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832558987854217216 |
|---|---|
| author | Arash Assadsangabi Caroline A. Evans Bernard M. Corfe Alan Lobo |
| author_facet | Arash Assadsangabi Caroline A. Evans Bernard M. Corfe Alan Lobo |
| author_sort | Arash Assadsangabi |
| collection | DOAJ |
| description | Inflammatory bowel disease (IBD) is a chronic relapsing/remitting inflammatory illness of the gastrointestinal tract of unknown aetiology. Despite recent advances in decoding the pathophysiology of IBD, many questions regarding disease pathogenesis remain. Genome-wide association studies (GWAS) and knockout mouse models have significantly advanced our understanding of genetic susceptibility loci and inflammatory pathways involved in IBD pathogenesis. Despite their important contribution to a better delineation of the disease process in IBD, these genetic findings have had little clinical impact to date. This is because the presence of a given gene mutation does not automatically correspond to changes in its expression or final metabolic or structural effect(s). Furthermore, the existence of these gene susceptibility loci in the normal population suggests other driving prerequisites for the disease manifestation. Proteins can be considered the main functional units as almost all intracellular physiological functions as well as intercellular interactions are dependent on them. Proteomics provides methods for the large-scale study of the proteins encoded by the genome of an organism or a cell, to directly investigate the proteins and pathways involved. Understanding the proteome composition and alterations yields insights into IBD pathogenesis as well as identifying potential biomarkers of disease activity, mucosal healing, and cancer progression. This review describes the state of the art in the field with respect to the study of IBD and the potential for translation from biomarker discovery to clinical application. |
| format | Article |
| id | doaj-art-2d2fce076d99425bb7020c44c0afe88d |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-2d2fce076d99425bb7020c44c0afe88d2025-02-03T01:31:03ZengWileyGastroenterology Research and Practice1687-61211687-630X2019-01-01201910.1155/2019/14269541426954Application of Proteomics to Inflammatory Bowel Disease Research: Current Status and Future PerspectivesArash Assadsangabi0Caroline A. Evans1Bernard M. Corfe2Alan Lobo3Gastroenterology Unit, Salford Royal Hospital, Salford, UKDepartment of Chemical and Biological Engineering, University of Sheffield, Sheffield, UKMolecular Gastroenterology Research Group, Academic Unit of Surgical Oncology, Department of Oncology and Insigneo Institute, University of Sheffield, Sheffield, UKGastroenterology Unit, Salford Royal Hospital, Salford, UKInflammatory bowel disease (IBD) is a chronic relapsing/remitting inflammatory illness of the gastrointestinal tract of unknown aetiology. Despite recent advances in decoding the pathophysiology of IBD, many questions regarding disease pathogenesis remain. Genome-wide association studies (GWAS) and knockout mouse models have significantly advanced our understanding of genetic susceptibility loci and inflammatory pathways involved in IBD pathogenesis. Despite their important contribution to a better delineation of the disease process in IBD, these genetic findings have had little clinical impact to date. This is because the presence of a given gene mutation does not automatically correspond to changes in its expression or final metabolic or structural effect(s). Furthermore, the existence of these gene susceptibility loci in the normal population suggests other driving prerequisites for the disease manifestation. Proteins can be considered the main functional units as almost all intracellular physiological functions as well as intercellular interactions are dependent on them. Proteomics provides methods for the large-scale study of the proteins encoded by the genome of an organism or a cell, to directly investigate the proteins and pathways involved. Understanding the proteome composition and alterations yields insights into IBD pathogenesis as well as identifying potential biomarkers of disease activity, mucosal healing, and cancer progression. This review describes the state of the art in the field with respect to the study of IBD and the potential for translation from biomarker discovery to clinical application.http://dx.doi.org/10.1155/2019/1426954 |
| spellingShingle | Arash Assadsangabi Caroline A. Evans Bernard M. Corfe Alan Lobo Application of Proteomics to Inflammatory Bowel Disease Research: Current Status and Future Perspectives Gastroenterology Research and Practice |
| title | Application of Proteomics to Inflammatory Bowel Disease Research: Current Status and Future Perspectives |
| title_full | Application of Proteomics to Inflammatory Bowel Disease Research: Current Status and Future Perspectives |
| title_fullStr | Application of Proteomics to Inflammatory Bowel Disease Research: Current Status and Future Perspectives |
| title_full_unstemmed | Application of Proteomics to Inflammatory Bowel Disease Research: Current Status and Future Perspectives |
| title_short | Application of Proteomics to Inflammatory Bowel Disease Research: Current Status and Future Perspectives |
| title_sort | application of proteomics to inflammatory bowel disease research current status and future perspectives |
| url | http://dx.doi.org/10.1155/2019/1426954 |
| work_keys_str_mv | AT arashassadsangabi applicationofproteomicstoinflammatoryboweldiseaseresearchcurrentstatusandfutureperspectives AT carolineaevans applicationofproteomicstoinflammatoryboweldiseaseresearchcurrentstatusandfutureperspectives AT bernardmcorfe applicationofproteomicstoinflammatoryboweldiseaseresearchcurrentstatusandfutureperspectives AT alanlobo applicationofproteomicstoinflammatoryboweldiseaseresearchcurrentstatusandfutureperspectives |