Association between incident falls and subsequent fractures in patients attending the fracture liaison service after an index fracture: a 3-year prospective observational cohort study
Objectives To evaluate the risk of subsequent fractures in patients who attended the Fracture Liaison Service (FLS), with and without incident falls after the index fracture.Design A 3-year prospective observational cohort study.Setting An outpatient FLS in the Netherlands.Participants Patients aged...
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BMJ Publishing Group
2022-07-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/7/e058983.full |
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| author | Piet Geusens Jacqueline R Center Tuan V Nguyen Thach Tran Johanna Driessen Joop P van den Bergh John Eisman Caroline E Wyers Lisanne Vranken Robert Y Van der Velde Heinrich M J Janzing Sjoerd Kaarsemakers Dana Bliuc |
| author_facet | Piet Geusens Jacqueline R Center Tuan V Nguyen Thach Tran Johanna Driessen Joop P van den Bergh John Eisman Caroline E Wyers Lisanne Vranken Robert Y Van der Velde Heinrich M J Janzing Sjoerd Kaarsemakers Dana Bliuc |
| author_sort | Piet Geusens |
| collection | DOAJ |
| description | Objectives To evaluate the risk of subsequent fractures in patients who attended the Fracture Liaison Service (FLS), with and without incident falls after the index fracture.Design A 3-year prospective observational cohort study.Setting An outpatient FLS in the Netherlands.Participants Patients aged 50+ years with a recent clinical fracture.Outcome measures Incident falls and subsequent fractures.Results The study included 488 patients (71.9% women, mean age: 64.6±8.6 years). During the 3-year follow-up, 959 falls had been ascertained in 296 patients (60.7%) (ie, fallers), and 60 subsequent fractures were ascertained in 53 patients (10.9%). Of the fractures, 47 (78.3%) were fall related, of which 25 (53.2%) were sustained at the first fall incident at a median of 34 weeks. An incident fall was associated with an approximately 9-fold (HR: 8.6, 95% CI 3.1 to 23.8) increase in the risk of subsequent fractures.Conclusion These data suggest that subsequent fractures among patients on treatment prescribed in an FLS setting are common, and that an incident fall is a strong predictor of subsequent fracture risk. Immediate attention for fall risk could be beneficial in an FLS model of care.Trial registration number NL45707.072.13. |
| format | Article |
| id | doaj-art-2d2b12b904c5471c8f304548dbcbf41d |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2022-07-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-2d2b12b904c5471c8f304548dbcbf41d2025-01-30T16:40:09ZengBMJ Publishing GroupBMJ Open2044-60552022-07-0112710.1136/bmjopen-2021-058983Association between incident falls and subsequent fractures in patients attending the fracture liaison service after an index fracture: a 3-year prospective observational cohort studyPiet Geusens0Jacqueline R Center1Tuan V Nguyen2Thach Tran3Johanna Driessen4Joop P van den Bergh5John Eisman6Caroline E Wyers7Lisanne Vranken8Robert Y Van der Velde9Heinrich M J Janzing10Sjoerd Kaarsemakers11Dana Bliuc12Faculty of Medicine and Life Sciences, Hasselt University, Diepenbeek, BelgiumGarvan Institute of Medical Research, Sydney, NSW, AustraliaDepartment of Osteoporosis and Bone Biology, Garvan Institute of Medical Research, Sydney, New South Wales, AustraliaBone Biology Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales, AustraliaDepartment of Clinical Pharmacy and Toxicology, Maastricht University Medical Centre+, Maastricht, The NetherlandsDepartment of Internal Medicine, Research School NUTRIM, Maastricht University Medical Centre+, Maastricht, The NetherlandsDepartment of Osteoporosis and Bone Biology, Garvan Institute of Medical Research, Sydney, New South Wales, AustraliaDepartment of Internal Medicine, VieCuri Medical Centre, Venlo, The NetherlandsDepartment of Internal Medicine, VieCuri Medical Centre, Venlo, The NetherlandsDepartment of Internal Medicine, VieCuri Medical Centre, Venlo, The NetherlandsDepartment of Surgery, VieCuri Medical Centre, Venlo, The NetherlandsDepartment of Orthopedic Surgery, VieCuri Medical Centre, Venlo, The Netherlandssenior research officerObjectives To evaluate the risk of subsequent fractures in patients who attended the Fracture Liaison Service (FLS), with and without incident falls after the index fracture.Design A 3-year prospective observational cohort study.Setting An outpatient FLS in the Netherlands.Participants Patients aged 50+ years with a recent clinical fracture.Outcome measures Incident falls and subsequent fractures.Results The study included 488 patients (71.9% women, mean age: 64.6±8.6 years). During the 3-year follow-up, 959 falls had been ascertained in 296 patients (60.7%) (ie, fallers), and 60 subsequent fractures were ascertained in 53 patients (10.9%). Of the fractures, 47 (78.3%) were fall related, of which 25 (53.2%) were sustained at the first fall incident at a median of 34 weeks. An incident fall was associated with an approximately 9-fold (HR: 8.6, 95% CI 3.1 to 23.8) increase in the risk of subsequent fractures.Conclusion These data suggest that subsequent fractures among patients on treatment prescribed in an FLS setting are common, and that an incident fall is a strong predictor of subsequent fracture risk. Immediate attention for fall risk could be beneficial in an FLS model of care.Trial registration number NL45707.072.13.https://bmjopen.bmj.com/content/12/7/e058983.full |
| spellingShingle | Piet Geusens Jacqueline R Center Tuan V Nguyen Thach Tran Johanna Driessen Joop P van den Bergh John Eisman Caroline E Wyers Lisanne Vranken Robert Y Van der Velde Heinrich M J Janzing Sjoerd Kaarsemakers Dana Bliuc Association between incident falls and subsequent fractures in patients attending the fracture liaison service after an index fracture: a 3-year prospective observational cohort study BMJ Open |
| title | Association between incident falls and subsequent fractures in patients attending the fracture liaison service after an index fracture: a 3-year prospective observational cohort study |
| title_full | Association between incident falls and subsequent fractures in patients attending the fracture liaison service after an index fracture: a 3-year prospective observational cohort study |
| title_fullStr | Association between incident falls and subsequent fractures in patients attending the fracture liaison service after an index fracture: a 3-year prospective observational cohort study |
| title_full_unstemmed | Association between incident falls and subsequent fractures in patients attending the fracture liaison service after an index fracture: a 3-year prospective observational cohort study |
| title_short | Association between incident falls and subsequent fractures in patients attending the fracture liaison service after an index fracture: a 3-year prospective observational cohort study |
| title_sort | association between incident falls and subsequent fractures in patients attending the fracture liaison service after an index fracture a 3 year prospective observational cohort study |
| url | https://bmjopen.bmj.com/content/12/7/e058983.full |
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