Effects of Gestational Inflammation with Postpartum Enriched Environment on Age-Related Changes in Cognition and Hippocampal Synaptic Plasticity-Related Proteins
Increasing evidence indicates that exposure to inflammation during pregnancy intensifies the offspring’s cognitive impairment during aging, which might be correlated with changes in some synaptic plasticity-related proteins. In addition, an enriched environment (EE) can significantly exert a benefic...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2020/9082945 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832550821792841728 |
|---|---|
| author | Shi-Yu Sun Xue-Yan Li He-Hua Ge Yu-Xin Zhang Zhe-Zhe Zhang Zhan-Qiang Zhuang Chong-Yang Ren Fang Wang Gui-Hai Chen |
| author_facet | Shi-Yu Sun Xue-Yan Li He-Hua Ge Yu-Xin Zhang Zhe-Zhe Zhang Zhan-Qiang Zhuang Chong-Yang Ren Fang Wang Gui-Hai Chen |
| author_sort | Shi-Yu Sun |
| collection | DOAJ |
| description | Increasing evidence indicates that exposure to inflammation during pregnancy intensifies the offspring’s cognitive impairment during aging, which might be correlated with changes in some synaptic plasticity-related proteins. In addition, an enriched environment (EE) can significantly exert a beneficial impact on cognition and synaptic plasticity. However, it is unclear whether gestational inflammation combined with postnatal EE affects the changes in cognition and synaptic plasticity-related proteins during aging. In this study, pregnant mice were intraperitoneally injected with lipopolysaccharides (LPS, 50 μg/kg) or normal saline at days 15–17 of pregnancy. At 21 days after delivery, some LPS-treated mice were randomly selected for EE treatment. At the age of 6 and 18 months, Morris water maze (MWM) and western blotting were, respectively, used to evaluate or measure the ability of spatial learning and memory and the levels of postsynaptic plasticity-related proteins in the hippocampus, including postsynaptic density protein 95 (PSD-95), α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) GluA1 subunit, and Homer-1b/c. The results showed that 18-month-old control mice had worse spatial learning and memory and lower levels of these synaptic plasticity-related proteins (PSD-95, GluA1, and Homer-1b/c) than the 6-month-old controls. Gestational LPS exposure exacerbated these age-related changes of cognition and synaptic proteins, but EE could alleviate the treatment effect of LPS. In addition, the performance during learning and memory periods in the MWM correlated with the hippocampal levels of PSD-95, GluA1, and Homer-1b/c. Our results suggested that gestational inflammation accelerated age-related cognitive impairment and the decline of PSD-95, GluA1, and Homer-1b/c protein expression, and postpartum EE could alleviate these changes. |
| format | Article |
| id | doaj-art-2d234e7521a249bdb3154f787bbb6927 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-2d234e7521a249bdb3154f787bbb69272025-02-03T06:05:44ZengWileyNeural Plasticity2090-59041687-54432020-01-01202010.1155/2020/90829459082945Effects of Gestational Inflammation with Postpartum Enriched Environment on Age-Related Changes in Cognition and Hippocampal Synaptic Plasticity-Related ProteinsShi-Yu Sun0Xue-Yan Li1He-Hua Ge2Yu-Xin Zhang3Zhe-Zhe Zhang4Zhan-Qiang Zhuang5Chong-Yang Ren6Fang Wang7Gui-Hai Chen8Department of Neurology (Sleep Disorders), The Affiliated Chaohu Hospital of Anhui Medical University, Hefei, 238000 Anhui Province, ChinaDepartment of Neurology (Sleep Disorders), The Affiliated Chaohu Hospital of Anhui Medical University, Hefei, 238000 Anhui Province, ChinaDepartment of Neurology (Sleep Disorders), The Affiliated Chaohu Hospital of Anhui Medical University, Hefei, 238000 Anhui Province, ChinaDepartment of Neurology, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601 Anhui Province, ChinaDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022 Anhui Province, ChinaDepartment of Neurology (Sleep Disorders), The Affiliated Chaohu Hospital of Anhui Medical University, Hefei, 238000 Anhui Province, ChinaDepartment of Neurology (Sleep Disorders), The Affiliated Chaohu Hospital of Anhui Medical University, Hefei, 238000 Anhui Province, ChinaDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022 Anhui Province, ChinaDepartment of Neurology (Sleep Disorders), The Affiliated Chaohu Hospital of Anhui Medical University, Hefei, 238000 Anhui Province, ChinaIncreasing evidence indicates that exposure to inflammation during pregnancy intensifies the offspring’s cognitive impairment during aging, which might be correlated with changes in some synaptic plasticity-related proteins. In addition, an enriched environment (EE) can significantly exert a beneficial impact on cognition and synaptic plasticity. However, it is unclear whether gestational inflammation combined with postnatal EE affects the changes in cognition and synaptic plasticity-related proteins during aging. In this study, pregnant mice were intraperitoneally injected with lipopolysaccharides (LPS, 50 μg/kg) or normal saline at days 15–17 of pregnancy. At 21 days after delivery, some LPS-treated mice were randomly selected for EE treatment. At the age of 6 and 18 months, Morris water maze (MWM) and western blotting were, respectively, used to evaluate or measure the ability of spatial learning and memory and the levels of postsynaptic plasticity-related proteins in the hippocampus, including postsynaptic density protein 95 (PSD-95), α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) GluA1 subunit, and Homer-1b/c. The results showed that 18-month-old control mice had worse spatial learning and memory and lower levels of these synaptic plasticity-related proteins (PSD-95, GluA1, and Homer-1b/c) than the 6-month-old controls. Gestational LPS exposure exacerbated these age-related changes of cognition and synaptic proteins, but EE could alleviate the treatment effect of LPS. In addition, the performance during learning and memory periods in the MWM correlated with the hippocampal levels of PSD-95, GluA1, and Homer-1b/c. Our results suggested that gestational inflammation accelerated age-related cognitive impairment and the decline of PSD-95, GluA1, and Homer-1b/c protein expression, and postpartum EE could alleviate these changes.http://dx.doi.org/10.1155/2020/9082945 |
| spellingShingle | Shi-Yu Sun Xue-Yan Li He-Hua Ge Yu-Xin Zhang Zhe-Zhe Zhang Zhan-Qiang Zhuang Chong-Yang Ren Fang Wang Gui-Hai Chen Effects of Gestational Inflammation with Postpartum Enriched Environment on Age-Related Changes in Cognition and Hippocampal Synaptic Plasticity-Related Proteins Neural Plasticity |
| title | Effects of Gestational Inflammation with Postpartum Enriched Environment on Age-Related Changes in Cognition and Hippocampal Synaptic Plasticity-Related Proteins |
| title_full | Effects of Gestational Inflammation with Postpartum Enriched Environment on Age-Related Changes in Cognition and Hippocampal Synaptic Plasticity-Related Proteins |
| title_fullStr | Effects of Gestational Inflammation with Postpartum Enriched Environment on Age-Related Changes in Cognition and Hippocampal Synaptic Plasticity-Related Proteins |
| title_full_unstemmed | Effects of Gestational Inflammation with Postpartum Enriched Environment on Age-Related Changes in Cognition and Hippocampal Synaptic Plasticity-Related Proteins |
| title_short | Effects of Gestational Inflammation with Postpartum Enriched Environment on Age-Related Changes in Cognition and Hippocampal Synaptic Plasticity-Related Proteins |
| title_sort | effects of gestational inflammation with postpartum enriched environment on age related changes in cognition and hippocampal synaptic plasticity related proteins |
| url | http://dx.doi.org/10.1155/2020/9082945 |
| work_keys_str_mv | AT shiyusun effectsofgestationalinflammationwithpostpartumenrichedenvironmentonagerelatedchangesincognitionandhippocampalsynapticplasticityrelatedproteins AT xueyanli effectsofgestationalinflammationwithpostpartumenrichedenvironmentonagerelatedchangesincognitionandhippocampalsynapticplasticityrelatedproteins AT hehuage effectsofgestationalinflammationwithpostpartumenrichedenvironmentonagerelatedchangesincognitionandhippocampalsynapticplasticityrelatedproteins AT yuxinzhang effectsofgestationalinflammationwithpostpartumenrichedenvironmentonagerelatedchangesincognitionandhippocampalsynapticplasticityrelatedproteins AT zhezhezhang effectsofgestationalinflammationwithpostpartumenrichedenvironmentonagerelatedchangesincognitionandhippocampalsynapticplasticityrelatedproteins AT zhanqiangzhuang effectsofgestationalinflammationwithpostpartumenrichedenvironmentonagerelatedchangesincognitionandhippocampalsynapticplasticityrelatedproteins AT chongyangren effectsofgestationalinflammationwithpostpartumenrichedenvironmentonagerelatedchangesincognitionandhippocampalsynapticplasticityrelatedproteins AT fangwang effectsofgestationalinflammationwithpostpartumenrichedenvironmentonagerelatedchangesincognitionandhippocampalsynapticplasticityrelatedproteins AT guihaichen effectsofgestationalinflammationwithpostpartumenrichedenvironmentonagerelatedchangesincognitionandhippocampalsynapticplasticityrelatedproteins |