Peptide nucleic acid-immobilised paper combined with multiplex recombinase polymerase amplification for the ultrasensitive and rapid detection of rifampicin-resistant tuberculosis

Peptide nucleic acid-immobilised paper combined with multiplex recombinase polymerase amplification for the ultrasensitive and rapid detection of rifampicin-resistant tuberculosis

Abstract Rifampicin-resistant tuberculosis (RR-TB) is a critical issue with significant implications for patient care, public health, and TB control efforts that necessitate comprehensive strategies for detection. This study presents a novel point-of-care diagnostic tool for RR-TB detection employin...

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Bibliographic Details
Main Authors: Nuttapon Jirakittiwut, Panuwat Sathianpitayakul, Pitak Santanirand, Yukihiro Akeda, Tirayut Vilaivan, Panan Ratthawongjirakul
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Peptide nucleic acid
Recombinase polymerase amplification
Rifampicin-resistant tuberculosis
Paper-based sensor
Online Access:https://doi.org/10.1038/s41598-025-86691-8
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