SOLVENT FREE SYNTHESIS OF CHALCONE AS ANTIBACTERIAL SUBSTANCE
The aims of this study was to synthesize a compound of 3-methoxy-4-hydroxychalcone through Claisen-Schmidt condensation with grinding technique (solvent-free). Vanillin, acetophenone and 60 % NaOH catalyst used in this synthesis. Characterization of products was done with a spectrophotometer FTIR an...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Universitas Sebelas Maret
2017-03-01
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| Series: | Alchemy |
| Subjects: | |
| Online Access: | https://jurnal.uns.ac.id/alchemy/article/view/4324 |
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| Summary: | The aims of this study was to synthesize a compound of 3-methoxy-4-hydroxychalcone through Claisen-Schmidt condensation with grinding technique (solvent-free). Vanillin, acetophenone and 60 % NaOH catalyst used in this synthesis. Characterization of products was done with a spectrophotometer FTIR and 1H-NMR spectrometer. The product was obtained as a orange solid which has a melting point at 58-59 ˚C. Identification of the product by IR spectrophotometer showed the absorption of C=C in the wavenumber of 1496.76 cm-1 which confirmed that the hydration reaction of chalcone had occurred. Analysis using 1H-NMR spectrometer also showed the proton of the CH=CH appearing on chemical shift (δ) 7.99 ppm. The antibacterial activity test showed that the compounds of 3-methoxy-4-hydroxychalcone has a potential as an antibacterial against bacteria E. coli and B. subtilis. |
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| ISSN: | 1412-4092 2443-4183 |