Association of ambient air pollutants with blood physiological and biochemical indicators and systemic immune inflammation index in people living around Beijing: an analysis of air pollution and population health data
ObjectiveTo investigate the association of ambient air pollutants with blood physiological and biochemical indicators and systemic immune inflammation index in people living around the Beijing metropolitan area and to provide a basis for formulating intervention policies on the health hazards of air...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
Editorial Office of Chinese Journal of Public Health
2024-11-01
|
| Series: | Zhongguo gonggong weisheng |
| Subjects: | |
| Online Access: | https://www.zgggws.com/article/doi/10.11847/zgggws1144645 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832591017931440128 |
|---|---|
| author | Bingqian DU Zhiqiang REN Peian CHEN Zhenjun LI |
| author_facet | Bingqian DU Zhiqiang REN Peian CHEN Zhenjun LI |
| author_sort | Bingqian DU |
| collection | DOAJ |
| description | ObjectiveTo investigate the association of ambient air pollutants with blood physiological and biochemical indicators and systemic immune inflammation index in people living around the Beijing metropolitan area and to provide a basis for formulating intervention policies on the health hazards of air pollution. MethodsData on demographics and blood physiological and biochemical indicators of 1 150 residents (8 – 90 years old) living around the Beijing metropolitan area, as well as monitoring data of air pollutants in the area for the period of 2018 – 2019, were collected from the Air Pollution and Population Health Database of the National Population Health Science Data Center. Correlation analysis was performed and multiple linear regression and restricted cubic spline (RCS) models were applied to assess the association of air pollutants with blood physiological and biochemical indicators and systemic immune inflammation index (SIRI). ResultsSpearman correlation analysis showed that the concentrations of particulate matter with an aerodynamic diameter of less than 2.5 μm (PM2.5) and carbon monoxide (CO) were positively correlated with monocyte count (MO#), eosinophil count (EOS#), and red blood cell distribution width standard deviation (RDW-SD), and negatively correlated with mean corpuscular hemoglobin concentration (MCHC) and platelet crit (PCT) (all P < 0.05). Particulate matter with an aerodynamic diameter of less than 10 μm (PM10) concentration was positively correlated with MO# and SIRI, and negatively correlated with mean corpuscular hemoglobin (MCH) and MCHC (all P < 0.01). Nitrogen dioxide (NO2) concentration was positively correlated with MO# and RDW-SD, and negatively correlated with MCHC and PCT (all P < 0.01). Sulfur dioxide (SO2) concentration was positively correlated with RDW-SD, and negatively correlated with neutrophil count (NEUT#) and MCHC (all P < 0.05). Ozone (O3) concentration was negatively correlated with EOS#, MCH, and MCHC (all P < 0.01). After adjusting for confounders such as gender and age, multiple linear regression analysis showed that for every 1 μg/m3 increase in PM2.5 concentration, MCHC decreased by 2.947 g/L; for every 1 μg/m3 increase in PM10 concentration, NEUT#, MO#, and SIRI increased by 0.236 × 109/L, 0.025 × 109/L, and 0.112, respectively; for each 1 μg/m3 increase in NO2 concentration, MO#, RDW-SD, and SIRI increased by 0.011×109/L, 0.136 fL, and 0.023, respectively, and MCHC decreased by 2.743 g/L; for every 1 μg/m3 increase in SO2 concentration, MCHC decreased by 1.871 g/L; for every 1 μg/m3 increase in CO concentration, MCHC and RDW-SD decreased by 1.383 g/L and 0.460 fL, respectively; for each 1 μg/m3 increase in O3 concentration, MO#, RDW-SD, and SIRI increased by 0.005×109/L, 0.113 fL, and 0.005, respectively, and MCHC decreased by 1.245 g/L. RCS model analysis showed an inverted U-shaped relationship between PM10 concentration and MO# and MCH, and between O3 concentration and SIRI (all P for nonlinearity < 0.05). A U-shaped relationship was observed between PM2.5 concentration and MO#, between PM10 concentration and PCT, and between CO concentration and MO# (all P for nonlinearity < 0.05). ConclusionsLong-term exposure to air pollutants such as PM2.5, PM10, NO2, SO2, CO, and O3 may increase the risk of systemic immune inflammation in the exposed population. |
| format | Article |
| id | doaj-art-2cf59c1bd76242498bc974f7eb5818b7 |
| institution | Kabale University |
| issn | 1001-0580 |
| language | zho |
| publishDate | 2024-11-01 |
| publisher | Editorial Office of Chinese Journal of Public Health |
| record_format | Article |
| series | Zhongguo gonggong weisheng |
| spelling | doaj-art-2cf59c1bd76242498bc974f7eb5818b72025-01-23T05:12:02ZzhoEditorial Office of Chinese Journal of Public HealthZhongguo gonggong weisheng1001-05802024-11-0140111336134010.11847/zgggws11446451144645Association of ambient air pollutants with blood physiological and biochemical indicators and systemic immune inflammation index in people living around Beijing: an analysis of air pollution and population health dataBingqian DU0Zhiqiang REN1Peian CHEN2Zhenjun LI3National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Chinese Center for Disease Control and Prevention, Beijing 102206, ChinaSchool of Public Health and Emergency Management, Southern University of Science and Technology, Shenzhen 518055, ChinaSchool of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Chinese Center for Disease Control and Prevention, Beijing 102206, ChinaObjectiveTo investigate the association of ambient air pollutants with blood physiological and biochemical indicators and systemic immune inflammation index in people living around the Beijing metropolitan area and to provide a basis for formulating intervention policies on the health hazards of air pollution. MethodsData on demographics and blood physiological and biochemical indicators of 1 150 residents (8 – 90 years old) living around the Beijing metropolitan area, as well as monitoring data of air pollutants in the area for the period of 2018 – 2019, were collected from the Air Pollution and Population Health Database of the National Population Health Science Data Center. Correlation analysis was performed and multiple linear regression and restricted cubic spline (RCS) models were applied to assess the association of air pollutants with blood physiological and biochemical indicators and systemic immune inflammation index (SIRI). ResultsSpearman correlation analysis showed that the concentrations of particulate matter with an aerodynamic diameter of less than 2.5 μm (PM2.5) and carbon monoxide (CO) were positively correlated with monocyte count (MO#), eosinophil count (EOS#), and red blood cell distribution width standard deviation (RDW-SD), and negatively correlated with mean corpuscular hemoglobin concentration (MCHC) and platelet crit (PCT) (all P < 0.05). Particulate matter with an aerodynamic diameter of less than 10 μm (PM10) concentration was positively correlated with MO# and SIRI, and negatively correlated with mean corpuscular hemoglobin (MCH) and MCHC (all P < 0.01). Nitrogen dioxide (NO2) concentration was positively correlated with MO# and RDW-SD, and negatively correlated with MCHC and PCT (all P < 0.01). Sulfur dioxide (SO2) concentration was positively correlated with RDW-SD, and negatively correlated with neutrophil count (NEUT#) and MCHC (all P < 0.05). Ozone (O3) concentration was negatively correlated with EOS#, MCH, and MCHC (all P < 0.01). After adjusting for confounders such as gender and age, multiple linear regression analysis showed that for every 1 μg/m3 increase in PM2.5 concentration, MCHC decreased by 2.947 g/L; for every 1 μg/m3 increase in PM10 concentration, NEUT#, MO#, and SIRI increased by 0.236 × 109/L, 0.025 × 109/L, and 0.112, respectively; for each 1 μg/m3 increase in NO2 concentration, MO#, RDW-SD, and SIRI increased by 0.011×109/L, 0.136 fL, and 0.023, respectively, and MCHC decreased by 2.743 g/L; for every 1 μg/m3 increase in SO2 concentration, MCHC decreased by 1.871 g/L; for every 1 μg/m3 increase in CO concentration, MCHC and RDW-SD decreased by 1.383 g/L and 0.460 fL, respectively; for each 1 μg/m3 increase in O3 concentration, MO#, RDW-SD, and SIRI increased by 0.005×109/L, 0.113 fL, and 0.005, respectively, and MCHC decreased by 1.245 g/L. RCS model analysis showed an inverted U-shaped relationship between PM10 concentration and MO# and MCH, and between O3 concentration and SIRI (all P for nonlinearity < 0.05). A U-shaped relationship was observed between PM2.5 concentration and MO#, between PM10 concentration and PCT, and between CO concentration and MO# (all P for nonlinearity < 0.05). ConclusionsLong-term exposure to air pollutants such as PM2.5, PM10, NO2, SO2, CO, and O3 may increase the risk of systemic immune inflammation in the exposed population.https://www.zgggws.com/article/doi/10.11847/zgggws1144645air pollutantssystemic immune inflammationrelationship |
| spellingShingle | Bingqian DU Zhiqiang REN Peian CHEN Zhenjun LI Association of ambient air pollutants with blood physiological and biochemical indicators and systemic immune inflammation index in people living around Beijing: an analysis of air pollution and population health data Zhongguo gonggong weisheng air pollutants systemic immune inflammation relationship |
| title | Association of ambient air pollutants with blood physiological and biochemical indicators and systemic immune inflammation index in people living around Beijing: an analysis of air pollution and population health data |
| title_full | Association of ambient air pollutants with blood physiological and biochemical indicators and systemic immune inflammation index in people living around Beijing: an analysis of air pollution and population health data |
| title_fullStr | Association of ambient air pollutants with blood physiological and biochemical indicators and systemic immune inflammation index in people living around Beijing: an analysis of air pollution and population health data |
| title_full_unstemmed | Association of ambient air pollutants with blood physiological and biochemical indicators and systemic immune inflammation index in people living around Beijing: an analysis of air pollution and population health data |
| title_short | Association of ambient air pollutants with blood physiological and biochemical indicators and systemic immune inflammation index in people living around Beijing: an analysis of air pollution and population health data |
| title_sort | association of ambient air pollutants with blood physiological and biochemical indicators and systemic immune inflammation index in people living around beijing an analysis of air pollution and population health data |
| topic | air pollutants systemic immune inflammation relationship |
| url | https://www.zgggws.com/article/doi/10.11847/zgggws1144645 |
| work_keys_str_mv | AT bingqiandu associationofambientairpollutantswithbloodphysiologicalandbiochemicalindicatorsandsystemicimmuneinflammationindexinpeoplelivingaroundbeijingananalysisofairpollutionandpopulationhealthdata AT zhiqiangren associationofambientairpollutantswithbloodphysiologicalandbiochemicalindicatorsandsystemicimmuneinflammationindexinpeoplelivingaroundbeijingananalysisofairpollutionandpopulationhealthdata AT peianchen associationofambientairpollutantswithbloodphysiologicalandbiochemicalindicatorsandsystemicimmuneinflammationindexinpeoplelivingaroundbeijingananalysisofairpollutionandpopulationhealthdata AT zhenjunli associationofambientairpollutantswithbloodphysiologicalandbiochemicalindicatorsandsystemicimmuneinflammationindexinpeoplelivingaroundbeijingananalysisofairpollutionandpopulationhealthdata |