PD-L1 monoclonal antibody alleviated MI injury of left ventricular function via modulating CD47/SHP2/SIRPα/SYK/FcγR signalings in tumor associated macrophages

PD-L1 monoclonal antibody alleviated MI injury of left ventricular function via modulating CD47/SHP2/SIRPα/SYK/FcγR signalings in tumor associated macrophages

Abstract To investigate how PD-L1 monoclonal antibodies (mAbs) affect the left ventricular function in mice with myocardial infarction (MI) and through what mechanisms they exert their effects. In vivo experiments were conducted using 27 female BALB/c mice, which were divided equally into 3 groups....

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Bibliographic Details
Main Authors: Deyou Kong, Yongzhen Chen, Yajuan Yin, Zhikun Liu, Fang Yang, Xiaohong Li, Dongxing Shen, Jun Zhang
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
PD-L1
CD47/SHP2/SIRPα/SYK/FcγR signaling pathway
cGAMP
Breast cancer
Myocardial infarction
Online Access:https://doi.org/10.1038/s41598-024-85065-w
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https://doi.org/10.1038/s41598-024-85065-w

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