Preclinical Models for Studying Fuchs Endothelial Corneal Dystrophy
Fuchs Endothelial Corneal Dystrophy (FECD) is a corneal endothelial disease that causes microenvironment alterations and endothelial cell loss, which leads to vision impairment. It has a high global prevalence, especially in elderly populations. FECD is also one of the leading indications of corneal...
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| Format: | Article |
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MDPI AG
2025-03-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/14/7/505 |
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| author | Fancheng Sun Lexie W. Q. Xi Wesley Luu Myagmartsend Enkhbat Dawn Neo Jodhbir S. Mehta Gary S. L. Peh Evelyn K. F. Yim |
| author_facet | Fancheng Sun Lexie W. Q. Xi Wesley Luu Myagmartsend Enkhbat Dawn Neo Jodhbir S. Mehta Gary S. L. Peh Evelyn K. F. Yim |
| author_sort | Fancheng Sun |
| collection | DOAJ |
| description | Fuchs Endothelial Corneal Dystrophy (FECD) is a corneal endothelial disease that causes microenvironment alterations and endothelial cell loss, which leads to vision impairment. It has a high global prevalence, especially in elderly populations. FECD is also one of the leading indications of corneal transplantation globally. Currently, there is no clearly defined canonical pathway for this disease, and it has been proposed that the combinatorial effects of genetic mutations and exogenous factors cause FECD. Clinical studies and observations have provided valuable knowledge and understanding of FECD, while preclinical studies are essential for gaining insights into disease progression and mechanisms for the development and testing of regenerative medicine therapies. In this review, we first introduce the proposed genetic and molecular pathologies of FECD. Notably, we discuss the impact of abnormal extracellular matrix deposition (guttata), endothelial-to-mesenchymal transition, cell senescence, and oxidative stress on the pathology and etiology of FECD. We review and summarize the in vitro cell models, ex vivo tissues, and in vivo animal models used to study FECD. The benefits and challenges of each model are also discussed. |
| format | Article |
| id | doaj-art-2ce6122c202244f8b89f881272bec99e |
| institution | DOAJ |
| issn | 2073-4409 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj-art-2ce6122c202244f8b89f881272bec99e2025-08-20T03:06:31ZengMDPI AGCells2073-44092025-03-0114750510.3390/cells14070505Preclinical Models for Studying Fuchs Endothelial Corneal DystrophyFancheng Sun0Lexie W. Q. Xi1Wesley Luu2Myagmartsend Enkhbat3Dawn Neo4Jodhbir S. Mehta5Gary S. L. Peh6Evelyn K. F. Yim7Department of Chemical Engineering, University of Waterloo, Waterloo, ON NL2 3G1, CanadaDepartment of Chemical Engineering, University of Waterloo, Waterloo, ON NL2 3G1, CanadaDepartment of Chemical Engineering, University of Waterloo, Waterloo, ON NL2 3G1, CanadaDepartment of Chemical Engineering, University of Waterloo, Waterloo, ON NL2 3G1, CanadaSingapore Eye Research Institute, Singapore 169856, SingaporeSingapore Eye Research Institute, Singapore 169856, SingaporeSingapore Eye Research Institute, Singapore 169856, SingaporeDepartment of Chemical Engineering, University of Waterloo, Waterloo, ON NL2 3G1, CanadaFuchs Endothelial Corneal Dystrophy (FECD) is a corneal endothelial disease that causes microenvironment alterations and endothelial cell loss, which leads to vision impairment. It has a high global prevalence, especially in elderly populations. FECD is also one of the leading indications of corneal transplantation globally. Currently, there is no clearly defined canonical pathway for this disease, and it has been proposed that the combinatorial effects of genetic mutations and exogenous factors cause FECD. Clinical studies and observations have provided valuable knowledge and understanding of FECD, while preclinical studies are essential for gaining insights into disease progression and mechanisms for the development and testing of regenerative medicine therapies. In this review, we first introduce the proposed genetic and molecular pathologies of FECD. Notably, we discuss the impact of abnormal extracellular matrix deposition (guttata), endothelial-to-mesenchymal transition, cell senescence, and oxidative stress on the pathology and etiology of FECD. We review and summarize the in vitro cell models, ex vivo tissues, and in vivo animal models used to study FECD. The benefits and challenges of each model are also discussed.https://www.mdpi.com/2073-4409/14/7/505Fuchs Endothelial Corneal Dystrophy (FECD)pathogenesiscorneal endothelial cells (CEnCs)disease modeling |
| spellingShingle | Fancheng Sun Lexie W. Q. Xi Wesley Luu Myagmartsend Enkhbat Dawn Neo Jodhbir S. Mehta Gary S. L. Peh Evelyn K. F. Yim Preclinical Models for Studying Fuchs Endothelial Corneal Dystrophy Cells Fuchs Endothelial Corneal Dystrophy (FECD) pathogenesis corneal endothelial cells (CEnCs) disease modeling |
| title | Preclinical Models for Studying Fuchs Endothelial Corneal Dystrophy |
| title_full | Preclinical Models for Studying Fuchs Endothelial Corneal Dystrophy |
| title_fullStr | Preclinical Models for Studying Fuchs Endothelial Corneal Dystrophy |
| title_full_unstemmed | Preclinical Models for Studying Fuchs Endothelial Corneal Dystrophy |
| title_short | Preclinical Models for Studying Fuchs Endothelial Corneal Dystrophy |
| title_sort | preclinical models for studying fuchs endothelial corneal dystrophy |
| topic | Fuchs Endothelial Corneal Dystrophy (FECD) pathogenesis corneal endothelial cells (CEnCs) disease modeling |
| url | https://www.mdpi.com/2073-4409/14/7/505 |
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