Integrating engineered nanomaterials with extracellular vesicles: advancing targeted drug delivery and biomedical applications
Extracellular vesicles (EVs), natural membrane-bound structures released by cells, offer a promising platform for precise and targeted delivery of therapeutic payloads, including drugs and nanoparticles. This comprehensive review explores the integration of engineered nanomaterials with EVs to advan...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Nanotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnano.2024.1513683/full |
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| author | Hai Jiang Ranil Vikraman Kumarasamy JinJin Pei Kamaraj Raju Gopalakrishnan Velliyur Kanniappan Chella Perumal Palanisamy Ion Dan Mironescu |
| author_facet | Hai Jiang Ranil Vikraman Kumarasamy JinJin Pei Kamaraj Raju Gopalakrishnan Velliyur Kanniappan Chella Perumal Palanisamy Ion Dan Mironescu |
| author_sort | Hai Jiang |
| collection | DOAJ |
| description | Extracellular vesicles (EVs), natural membrane-bound structures released by cells, offer a promising platform for precise and targeted delivery of therapeutic payloads, including drugs and nanoparticles. This comprehensive review explores the integration of engineered nanomaterials with EVs to advance drug delivery systems. It covers various aspects of this integration, including techniques for synthesizing, loading, characterizing, and applying nanomaterials within EVs. Methodologies for integrating diverse nanocarriers like nanoparticles, liposomes, and quantum dots into EVs are discussed, along with characterization methods such as electron microscopy and light scattering. Attention is also given to considerations of biological compatibility, safety assessments, and strategies for surface modification to enhance targeting precision. Highlighting various applications, including targeted drug delivery, cancer therapy, and vaccine development, the review underscores the potential of EV-nanomaterial hybrids to leverage EVs’ innate targeting capabilities and the versatility of nanomaterials. However, it also addresses challenges such as scalability, standardization, and safety that must be overcome to facilitate the clinical translation of these promising biomedical solutions. |
| format | Article |
| id | doaj-art-2ce11cb00b5440c7ab7a96d0fbc73226 |
| institution | Kabale University |
| issn | 2673-3013 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nanotechnology |
| spelling | doaj-art-2ce11cb00b5440c7ab7a96d0fbc732262025-01-22T07:13:37ZengFrontiers Media S.A.Frontiers in Nanotechnology2673-30132025-01-01610.3389/fnano.2024.15136831513683Integrating engineered nanomaterials with extracellular vesicles: advancing targeted drug delivery and biomedical applicationsHai Jiang0Ranil Vikraman Kumarasamy1JinJin Pei2Kamaraj Raju3Gopalakrishnan Velliyur Kanniappan4Chella Perumal Palanisamy5Ion Dan Mironescu6Qinba State Key Laboratory of Biological Resources and Ecological Environment, 2011 QinLing-Bashan Mountains Bioresources Comprehensive Development C. I. C, Shaanxi Province Key Laboratory of Bio-Resources, College of Bioscience and Bioengineering, Shaanxi University of Technology, Hanzhong, ChinaDepartment of Biochemistry, Bharathidasan University, Tiruchirappalli, Tamil Nadu, IndiaQinba State Key Laboratory of Biological Resources and Ecological Environment, 2011 QinLing-Bashan Mountains Bioresources Comprehensive Development C. I. C, Shaanxi Province Key Laboratory of Bio-Resources, College of Bioscience and Bioengineering, Shaanxi University of Technology, Hanzhong, ChinaDepartment of Biotechnology, Rathinam College of Arts and Science, Coimbatore, Tamil Nadu, IndiaCentre for Global Health Research, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IndiaDepartment of Chemical Technology, Faculty of Science, Chulalongkorn University, Bangkok, ThailandFaculty of Agricultural Sciences Food Industry and Environmental Protection, Lucian Blaga University of Sibiu, Sibiu, RomaniaExtracellular vesicles (EVs), natural membrane-bound structures released by cells, offer a promising platform for precise and targeted delivery of therapeutic payloads, including drugs and nanoparticles. This comprehensive review explores the integration of engineered nanomaterials with EVs to advance drug delivery systems. It covers various aspects of this integration, including techniques for synthesizing, loading, characterizing, and applying nanomaterials within EVs. Methodologies for integrating diverse nanocarriers like nanoparticles, liposomes, and quantum dots into EVs are discussed, along with characterization methods such as electron microscopy and light scattering. Attention is also given to considerations of biological compatibility, safety assessments, and strategies for surface modification to enhance targeting precision. Highlighting various applications, including targeted drug delivery, cancer therapy, and vaccine development, the review underscores the potential of EV-nanomaterial hybrids to leverage EVs’ innate targeting capabilities and the versatility of nanomaterials. However, it also addresses challenges such as scalability, standardization, and safety that must be overcome to facilitate the clinical translation of these promising biomedical solutions.https://www.frontiersin.org/articles/10.3389/fnano.2024.1513683/fullengineered nanomaterialsextracellular vesiclescharacterizationtargeted drug deliverybiomedical applications |
| spellingShingle | Hai Jiang Ranil Vikraman Kumarasamy JinJin Pei Kamaraj Raju Gopalakrishnan Velliyur Kanniappan Chella Perumal Palanisamy Ion Dan Mironescu Integrating engineered nanomaterials with extracellular vesicles: advancing targeted drug delivery and biomedical applications Frontiers in Nanotechnology engineered nanomaterials extracellular vesicles characterization targeted drug delivery biomedical applications |
| title | Integrating engineered nanomaterials with extracellular vesicles: advancing targeted drug delivery and biomedical applications |
| title_full | Integrating engineered nanomaterials with extracellular vesicles: advancing targeted drug delivery and biomedical applications |
| title_fullStr | Integrating engineered nanomaterials with extracellular vesicles: advancing targeted drug delivery and biomedical applications |
| title_full_unstemmed | Integrating engineered nanomaterials with extracellular vesicles: advancing targeted drug delivery and biomedical applications |
| title_short | Integrating engineered nanomaterials with extracellular vesicles: advancing targeted drug delivery and biomedical applications |
| title_sort | integrating engineered nanomaterials with extracellular vesicles advancing targeted drug delivery and biomedical applications |
| topic | engineered nanomaterials extracellular vesicles characterization targeted drug delivery biomedical applications |
| url | https://www.frontiersin.org/articles/10.3389/fnano.2024.1513683/full |
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