Surveillance Following Hepatitis B Surface Antigen Loss: An Issue Requiring Attention
Due to the lack of agents that directly target covalently closed circular DNA and integrated HBV DNA in hepatocytes, achieving a complete cure for chronic hepatitis B (CHB) remains challenging. The latest guidelines recommend (hepatitis B surface antigen) HBsAg loss as the ideal treatment target for...
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MDPI AG
2024-12-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/14/1/8 |
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| author | Shuai-Wen Huang Hong Long Jia-Quan Huang |
| author_facet | Shuai-Wen Huang Hong Long Jia-Quan Huang |
| author_sort | Shuai-Wen Huang |
| collection | DOAJ |
| description | Due to the lack of agents that directly target covalently closed circular DNA and integrated HBV DNA in hepatocytes, achieving a complete cure for chronic hepatitis B (CHB) remains challenging. The latest guidelines recommend (hepatitis B surface antigen) HBsAg loss as the ideal treatment target for improving liver function, histopathology, and long-term prognosis. However, even after HBsAg loss, hepatitis B virus can persist, with a risk of recurrence, reactivation, cirrhosis, and hepatocellular carcinoma. Therefore, follow-up and surveillance are still necessary. With increasing treatment options available for achieving HBsAg loss in patients with CHB, developing effective surveillance strategies has become crucial. Recent studies on outcomes following HBsAg loss provide new insights for refining current surveillance strategies, though further improvement is needed through long-term observation and follow-up. |
| format | Article |
| id | doaj-art-2cdf9449006e4d8ea2a520ae1b543a30 |
| institution | Kabale University |
| issn | 2076-0817 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj-art-2cdf9449006e4d8ea2a520ae1b543a302025-01-24T13:44:34ZengMDPI AGPathogens2076-08172024-12-01141810.3390/pathogens14010008Surveillance Following Hepatitis B Surface Antigen Loss: An Issue Requiring AttentionShuai-Wen Huang0Hong Long1Jia-Quan Huang2Department of General Practice, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, ChinaDepartment of General Practice, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, ChinaDepartment and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, ChinaDue to the lack of agents that directly target covalently closed circular DNA and integrated HBV DNA in hepatocytes, achieving a complete cure for chronic hepatitis B (CHB) remains challenging. The latest guidelines recommend (hepatitis B surface antigen) HBsAg loss as the ideal treatment target for improving liver function, histopathology, and long-term prognosis. However, even after HBsAg loss, hepatitis B virus can persist, with a risk of recurrence, reactivation, cirrhosis, and hepatocellular carcinoma. Therefore, follow-up and surveillance are still necessary. With increasing treatment options available for achieving HBsAg loss in patients with CHB, developing effective surveillance strategies has become crucial. Recent studies on outcomes following HBsAg loss provide new insights for refining current surveillance strategies, though further improvement is needed through long-term observation and follow-up.https://www.mdpi.com/2076-0817/14/1/8HBsAg losssurveillanceHBsAg recurrenceHBV reactivationHBV reinfectioncirrhosis |
| spellingShingle | Shuai-Wen Huang Hong Long Jia-Quan Huang Surveillance Following Hepatitis B Surface Antigen Loss: An Issue Requiring Attention Pathogens HBsAg loss surveillance HBsAg recurrence HBV reactivation HBV reinfection cirrhosis |
| title | Surveillance Following Hepatitis B Surface Antigen Loss: An Issue Requiring Attention |
| title_full | Surveillance Following Hepatitis B Surface Antigen Loss: An Issue Requiring Attention |
| title_fullStr | Surveillance Following Hepatitis B Surface Antigen Loss: An Issue Requiring Attention |
| title_full_unstemmed | Surveillance Following Hepatitis B Surface Antigen Loss: An Issue Requiring Attention |
| title_short | Surveillance Following Hepatitis B Surface Antigen Loss: An Issue Requiring Attention |
| title_sort | surveillance following hepatitis b surface antigen loss an issue requiring attention |
| topic | HBsAg loss surveillance HBsAg recurrence HBV reactivation HBV reinfection cirrhosis |
| url | https://www.mdpi.com/2076-0817/14/1/8 |
| work_keys_str_mv | AT shuaiwenhuang surveillancefollowinghepatitisbsurfaceantigenlossanissuerequiringattention AT honglong surveillancefollowinghepatitisbsurfaceantigenlossanissuerequiringattention AT jiaquanhuang surveillancefollowinghepatitisbsurfaceantigenlossanissuerequiringattention |