Estimation of Antioxidant Levels in Saliva and Serum of Chronic Periodontitis Patients with and without Ischemic Heart Disease
Objective. To investigate whether there is a relationship between periodontitis and ischemic heart disease by estimation of total antioxidant status in saliva and serum. Materials and Methods. A total of 80 samples were collected and divided equally into 4 groups of healthy controls, chronic periodo...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | International Journal of Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2017/1965697 |
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| author | Anahita Punj Santhosh Shenoy N. Suchetha Kumari Priyanka Pampani |
| author_facet | Anahita Punj Santhosh Shenoy N. Suchetha Kumari Priyanka Pampani |
| author_sort | Anahita Punj |
| collection | DOAJ |
| description | Objective. To investigate whether there is a relationship between periodontitis and ischemic heart disease by estimation of total antioxidant status in saliva and serum. Materials and Methods. A total of 80 samples were collected and divided equally into 4 groups of healthy controls, chronic periodontitis patients, ischemic heart disease patients with periodontitis, and ischemic heart disease patients without periodontitis. Saliva and venous blood samples were collected and analyzed for levels of total antioxidant capacity, superoxide dismutase, glutathione peroxidase, and catalase. Results. There were significant (p<0.05) differences in the mean serum levels of total antioxidant capacity (p<0.001), superoxide dismutase (p<0.001), glutathione peroxidase (p<0.006), and catalase (p<0.001) within the 4 groups, whereas the mean salivary levels were significant only for glutathione peroxidase (p=0.001). Both of these serum and salivary antioxidant levels were lower in disease groups of IHD + CP, IHD + H, and CP as compared to healthy controls, with different patterns. Conclusion. Antioxidant capacity is significantly hampered in chronic periodontitis and ischemic heart disease patients with or without periodontitis as compared to healthy controls. The salivary and serum antioxidants may not follow the same increase or decrease as a result of increased oxidant stress due to disease. |
| format | Article |
| id | doaj-art-2cb84cbdc43f40938d08a43885b9b9f6 |
| institution | Kabale University |
| issn | 1687-8728 1687-8736 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Dentistry |
| spelling | doaj-art-2cb84cbdc43f40938d08a43885b9b9f62025-02-03T01:12:14ZengWileyInternational Journal of Dentistry1687-87281687-87362017-01-01201710.1155/2017/19656971965697Estimation of Antioxidant Levels in Saliva and Serum of Chronic Periodontitis Patients with and without Ischemic Heart DiseaseAnahita Punj0Santhosh Shenoy1N. Suchetha Kumari2Priyanka Pampani3Department of Periodontics, A.B. Shetty Memorial Institute of Dental Sciences, Nitte University, Deralakatte, Mangalore, Karnataka 575018, IndiaDepartment of Periodontics, A.B. Shetty Memorial Institute of Dental Sciences, Nitte University, Deralakatte, Mangalore, Karnataka 575018, IndiaDepartment of Biochemistry, K.S. Hegde Medical Academy, Nitte University, Deralakatte, Mangalore, Karnataka 575018, IndiaDepartment of Periodontics, A.B. Shetty Memorial Institute of Dental Sciences, Nitte University, Deralakatte, Mangalore, Karnataka 575018, IndiaObjective. To investigate whether there is a relationship between periodontitis and ischemic heart disease by estimation of total antioxidant status in saliva and serum. Materials and Methods. A total of 80 samples were collected and divided equally into 4 groups of healthy controls, chronic periodontitis patients, ischemic heart disease patients with periodontitis, and ischemic heart disease patients without periodontitis. Saliva and venous blood samples were collected and analyzed for levels of total antioxidant capacity, superoxide dismutase, glutathione peroxidase, and catalase. Results. There were significant (p<0.05) differences in the mean serum levels of total antioxidant capacity (p<0.001), superoxide dismutase (p<0.001), glutathione peroxidase (p<0.006), and catalase (p<0.001) within the 4 groups, whereas the mean salivary levels were significant only for glutathione peroxidase (p=0.001). Both of these serum and salivary antioxidant levels were lower in disease groups of IHD + CP, IHD + H, and CP as compared to healthy controls, with different patterns. Conclusion. Antioxidant capacity is significantly hampered in chronic periodontitis and ischemic heart disease patients with or without periodontitis as compared to healthy controls. The salivary and serum antioxidants may not follow the same increase or decrease as a result of increased oxidant stress due to disease.http://dx.doi.org/10.1155/2017/1965697 |
| spellingShingle | Anahita Punj Santhosh Shenoy N. Suchetha Kumari Priyanka Pampani Estimation of Antioxidant Levels in Saliva and Serum of Chronic Periodontitis Patients with and without Ischemic Heart Disease International Journal of Dentistry |
| title | Estimation of Antioxidant Levels in Saliva and Serum of Chronic Periodontitis Patients with and without Ischemic Heart Disease |
| title_full | Estimation of Antioxidant Levels in Saliva and Serum of Chronic Periodontitis Patients with and without Ischemic Heart Disease |
| title_fullStr | Estimation of Antioxidant Levels in Saliva and Serum of Chronic Periodontitis Patients with and without Ischemic Heart Disease |
| title_full_unstemmed | Estimation of Antioxidant Levels in Saliva and Serum of Chronic Periodontitis Patients with and without Ischemic Heart Disease |
| title_short | Estimation of Antioxidant Levels in Saliva and Serum of Chronic Periodontitis Patients with and without Ischemic Heart Disease |
| title_sort | estimation of antioxidant levels in saliva and serum of chronic periodontitis patients with and without ischemic heart disease |
| url | http://dx.doi.org/10.1155/2017/1965697 |
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