Modulatory effect of Echium plantagineum oil on the n-3 LC-PUFA biosynthetic capacity of chicken (Gallus gallus)
Poultry can be a sustainable source of eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3) through the bioconversion of dietary alpha-linolenic acid (ALA, 18:3n-3). However, this process is currently limited by the high n-6/n-3 ratio in poultry diets affecting the competitio...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-02-01
|
| Series: | Poultry Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0032579125000574 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832594126776827904 |
|---|---|
| author | Jesús Villora José Antonio Pérez Nieves Guadalupe Acosta Deiene Rodríguez-Barreto Pedro Juan Alonso Mónica B. Betancor Alexandr Torres Sergio Álvarez Covadonga Rodríguez |
| author_facet | Jesús Villora José Antonio Pérez Nieves Guadalupe Acosta Deiene Rodríguez-Barreto Pedro Juan Alonso Mónica B. Betancor Alexandr Torres Sergio Álvarez Covadonga Rodríguez |
| author_sort | Jesús Villora |
| collection | DOAJ |
| description | Poultry can be a sustainable source of eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3) through the bioconversion of dietary alpha-linolenic acid (ALA, 18:3n-3). However, this process is currently limited by the high n-6/n-3 ratio in poultry diets affecting the competition between n-6 and n-3 fatty acids (FA) for the same biosynthetic enzymes, and the rate-limiting Δ6 desaturase which act at both, the first and final steps of DHA synthesis pathway. Echium plantagineum oil (EO) is an unusual source of stearidonic acid (SDA, 18:4n-3) which bypasses the first Δ6 desaturase step potentially increasing n-3 long-chain polyunsaturated fatty acids (LC-PUFA) synthesis. To explore this hypothesis, 60 Canarian male chickens at 18 weeks of age were divided into three groups and fed diets differing only in their FA formulation: soy oil (SO) rich in linoleic acid (LA, 18:2n-6); linseed oil (LO) rich in ALA; and EO, a balanced LA/ALA oil also rich in SDA and γ-linolenic acid (GLA, 18:3n-6). The dietary treatments did not affect the total lipid (TL) content (p>0.05) and did not substantially vary the lipid class (LC) profiles in the brain, liver, intestine, and muscle tissues. However, the inclusion of LO and EO equally increased n-3 polyunsaturated fatty acids (PUFA) levels in the brain, liver, and intestine compared to animals fed with SO (p<0.05). Moreover, EO increased hepatic relative expressions of the fatty acid elongases (elovl2 and elovl5). Consequently, and in alignment with our hypothesis, EO was more effective than LO in enriching chicken thigh meat with n-3 LC-PUFA (6.0 vs 4.2%; p<0.05). We concluded that lowering the dietary LA/ALA ratio and increasing the SDA content in poultry diets enhance the potential of chicken metabolism for enriching poultry products with n-3 LC-PUFA. Emerging evidence suggest that local plants like those including in Echium genus, rich in SDA and with a balanced LA/ALA ratio, could offer a more sustainable and efficient alternative to traditional ALA sources in poultry production. |
| format | Article |
| id | doaj-art-2cb1c1866d4745a69cb4e540fe22804f |
| institution | Kabale University |
| issn | 0032-5791 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Poultry Science |
| spelling | doaj-art-2cb1c1866d4745a69cb4e540fe22804f2025-01-20T04:17:15ZengElsevierPoultry Science0032-57912025-02-011042104820Modulatory effect of Echium plantagineum oil on the n-3 LC-PUFA biosynthetic capacity of chicken (Gallus gallus)Jesús Villora0José Antonio Pérez1Nieves Guadalupe Acosta2Deiene Rodríguez-Barreto3Pedro Juan Alonso4Mónica B. Betancor5Alexandr Torres6Sergio Álvarez7Covadonga Rodríguez8Departamento de Biología Animal, Edafología y Geología, Universidad de La Laguna. Avenida Astrofísico Francisco Sánchez s/n, 38206 La Laguna, Tenerife, Spain; Unidad de Producción Animal, Pastos y Forrajes en Zonas Áridas y Subtropicales, Instituto Canario de Investigaciones Agrarias, 38200 San Cristóbal de La Laguna, Tenerife, Spain; Corresponding author at: 38206 La Laguna, Tenerife, Spain.Departamento de Biología Animal, Edafología y Geología, Universidad de La Laguna. Avenida Astrofísico Francisco Sánchez s/n, 38206 La Laguna, Tenerife, SpainDepartamento de Biología Animal, Edafología y Geología, Universidad de La Laguna. Avenida Astrofísico Francisco Sánchez s/n, 38206 La Laguna, Tenerife, SpainDepartamento de Biología Animal, Edafología y Geología, Universidad de La Laguna. Avenida Astrofísico Francisco Sánchez s/n, 38206 La Laguna, Tenerife, SpainGraneros de Tenerife S.L., Departamento Técnico Grupo Capisa. Avda. República de Nicaragua, 11-13, 35010 Las Palmas de Gran Canaria, Gran Canaria, SpainInstitute of Aquaculture, Faculty of Natural Sciences, University of Stirling. Stirling FK9 4LA, UKUnidad de Producción Animal, Pastos y Forrajes en Zonas Áridas y Subtropicales, Instituto Canario de Investigaciones Agrarias, 38200 San Cristóbal de La Laguna, Tenerife, SpainUnidad de Producción Animal, Pastos y Forrajes en Zonas Áridas y Subtropicales, Instituto Canario de Investigaciones Agrarias, 38200 San Cristóbal de La Laguna, Tenerife, SpainDepartamento de Biología Animal, Edafología y Geología, Universidad de La Laguna. Avenida Astrofísico Francisco Sánchez s/n, 38206 La Laguna, Tenerife, SpainPoultry can be a sustainable source of eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3) through the bioconversion of dietary alpha-linolenic acid (ALA, 18:3n-3). However, this process is currently limited by the high n-6/n-3 ratio in poultry diets affecting the competition between n-6 and n-3 fatty acids (FA) for the same biosynthetic enzymes, and the rate-limiting Δ6 desaturase which act at both, the first and final steps of DHA synthesis pathway. Echium plantagineum oil (EO) is an unusual source of stearidonic acid (SDA, 18:4n-3) which bypasses the first Δ6 desaturase step potentially increasing n-3 long-chain polyunsaturated fatty acids (LC-PUFA) synthesis. To explore this hypothesis, 60 Canarian male chickens at 18 weeks of age were divided into three groups and fed diets differing only in their FA formulation: soy oil (SO) rich in linoleic acid (LA, 18:2n-6); linseed oil (LO) rich in ALA; and EO, a balanced LA/ALA oil also rich in SDA and γ-linolenic acid (GLA, 18:3n-6). The dietary treatments did not affect the total lipid (TL) content (p>0.05) and did not substantially vary the lipid class (LC) profiles in the brain, liver, intestine, and muscle tissues. However, the inclusion of LO and EO equally increased n-3 polyunsaturated fatty acids (PUFA) levels in the brain, liver, and intestine compared to animals fed with SO (p<0.05). Moreover, EO increased hepatic relative expressions of the fatty acid elongases (elovl2 and elovl5). Consequently, and in alignment with our hypothesis, EO was more effective than LO in enriching chicken thigh meat with n-3 LC-PUFA (6.0 vs 4.2%; p<0.05). We concluded that lowering the dietary LA/ALA ratio and increasing the SDA content in poultry diets enhance the potential of chicken metabolism for enriching poultry products with n-3 LC-PUFA. Emerging evidence suggest that local plants like those including in Echium genus, rich in SDA and with a balanced LA/ALA ratio, could offer a more sustainable and efficient alternative to traditional ALA sources in poultry production.http://www.sciencedirect.com/science/article/pii/S0032579125000574DesaturationElongationGene expressionLipid metabolismPoultry |
| spellingShingle | Jesús Villora José Antonio Pérez Nieves Guadalupe Acosta Deiene Rodríguez-Barreto Pedro Juan Alonso Mónica B. Betancor Alexandr Torres Sergio Álvarez Covadonga Rodríguez Modulatory effect of Echium plantagineum oil on the n-3 LC-PUFA biosynthetic capacity of chicken (Gallus gallus) Poultry Science Desaturation Elongation Gene expression Lipid metabolism Poultry |
| title | Modulatory effect of Echium plantagineum oil on the n-3 LC-PUFA biosynthetic capacity of chicken (Gallus gallus) |
| title_full | Modulatory effect of Echium plantagineum oil on the n-3 LC-PUFA biosynthetic capacity of chicken (Gallus gallus) |
| title_fullStr | Modulatory effect of Echium plantagineum oil on the n-3 LC-PUFA biosynthetic capacity of chicken (Gallus gallus) |
| title_full_unstemmed | Modulatory effect of Echium plantagineum oil on the n-3 LC-PUFA biosynthetic capacity of chicken (Gallus gallus) |
| title_short | Modulatory effect of Echium plantagineum oil on the n-3 LC-PUFA biosynthetic capacity of chicken (Gallus gallus) |
| title_sort | modulatory effect of echium plantagineum oil on the n 3 lc pufa biosynthetic capacity of chicken gallus gallus |
| topic | Desaturation Elongation Gene expression Lipid metabolism Poultry |
| url | http://www.sciencedirect.com/science/article/pii/S0032579125000574 |
| work_keys_str_mv | AT jesusvillora modulatoryeffectofechiumplantagineumoilonthen3lcpufabiosyntheticcapacityofchickengallusgallus AT joseantonioperez modulatoryeffectofechiumplantagineumoilonthen3lcpufabiosyntheticcapacityofchickengallusgallus AT nievesguadalupeacosta modulatoryeffectofechiumplantagineumoilonthen3lcpufabiosyntheticcapacityofchickengallusgallus AT deienerodriguezbarreto modulatoryeffectofechiumplantagineumoilonthen3lcpufabiosyntheticcapacityofchickengallusgallus AT pedrojuanalonso modulatoryeffectofechiumplantagineumoilonthen3lcpufabiosyntheticcapacityofchickengallusgallus AT monicabbetancor modulatoryeffectofechiumplantagineumoilonthen3lcpufabiosyntheticcapacityofchickengallusgallus AT alexandrtorres modulatoryeffectofechiumplantagineumoilonthen3lcpufabiosyntheticcapacityofchickengallusgallus AT sergioalvarez modulatoryeffectofechiumplantagineumoilonthen3lcpufabiosyntheticcapacityofchickengallusgallus AT covadongarodriguez modulatoryeffectofechiumplantagineumoilonthen3lcpufabiosyntheticcapacityofchickengallusgallus |