Synthesis and Cytotoxicity of Chalcones and 5-Deoxyflavonoids
Chalcones 1~8 and 5-deoxyflavonoids 9~22 were synthesized in good yields by aldol condensation, Algar-Flynn-Oyamada reaction, glycosidation, and deacetylation reaction, respectively, starting from 2-acetyl phenols substituted by methoxy or methoxymethoxy group and appropriately benzaldehydes substit...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/649485 |
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| author | Jing Zhang Xin-Ling Fu Nan Yang Qiu-An Wang |
| author_facet | Jing Zhang Xin-Ling Fu Nan Yang Qiu-An Wang |
| author_sort | Jing Zhang |
| collection | DOAJ |
| description | Chalcones 1~8 and 5-deoxyflavonoids 9~22 were synthesized in good yields by aldol condensation, Algar-Flynn-Oyamada reaction, glycosidation, and deacetylation reaction, respectively, starting from 2-acetyl phenols substituted by methoxy or methoxymethoxy group and appropriately benzaldehydes substituted by methoxy, methoxymethoxy group, or chlorine. Among them, 13 and 17~22 are new compounds. The cytotoxicity bioassays of these chalcones and 5-deoxyflavonoids were screened using the sulforhodamine B (SRB) protein staining method, and the results showed that compounds 2, 4, 5, 6, 10, 15, and 19 exhibited moderate cytotoxicity against the cancer cell line of MDA-MB-231, U251, BGC-823, and B16 in comparison with control drugs (HCPT, Vincristine, and Taxol). |
| format | Article |
| id | doaj-art-2ca5187c83164d8aa10b78dbe15c6fd9 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-2ca5187c83164d8aa10b78dbe15c6fd92025-02-03T05:50:07ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/649485649485Synthesis and Cytotoxicity of Chalcones and 5-DeoxyflavonoidsJing Zhang0Xin-Ling Fu1Nan Yang2Qiu-An Wang3College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, ChinaDepartment of Basic Medical, Changsha Medical University, Changsha 410082, ChinaCollege of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, ChinaCollege of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, ChinaChalcones 1~8 and 5-deoxyflavonoids 9~22 were synthesized in good yields by aldol condensation, Algar-Flynn-Oyamada reaction, glycosidation, and deacetylation reaction, respectively, starting from 2-acetyl phenols substituted by methoxy or methoxymethoxy group and appropriately benzaldehydes substituted by methoxy, methoxymethoxy group, or chlorine. Among them, 13 and 17~22 are new compounds. The cytotoxicity bioassays of these chalcones and 5-deoxyflavonoids were screened using the sulforhodamine B (SRB) protein staining method, and the results showed that compounds 2, 4, 5, 6, 10, 15, and 19 exhibited moderate cytotoxicity against the cancer cell line of MDA-MB-231, U251, BGC-823, and B16 in comparison with control drugs (HCPT, Vincristine, and Taxol).http://dx.doi.org/10.1155/2013/649485 |
| spellingShingle | Jing Zhang Xin-Ling Fu Nan Yang Qiu-An Wang Synthesis and Cytotoxicity of Chalcones and 5-Deoxyflavonoids The Scientific World Journal |
| title | Synthesis and Cytotoxicity of Chalcones and 5-Deoxyflavonoids |
| title_full | Synthesis and Cytotoxicity of Chalcones and 5-Deoxyflavonoids |
| title_fullStr | Synthesis and Cytotoxicity of Chalcones and 5-Deoxyflavonoids |
| title_full_unstemmed | Synthesis and Cytotoxicity of Chalcones and 5-Deoxyflavonoids |
| title_short | Synthesis and Cytotoxicity of Chalcones and 5-Deoxyflavonoids |
| title_sort | synthesis and cytotoxicity of chalcones and 5 deoxyflavonoids |
| url | http://dx.doi.org/10.1155/2013/649485 |
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