Keratin/chitosan film promotes wound healing in rats with combined radiation-wound injury
Abstract Human hair keratin, a natural protein derived from human hair, has emerged prominently in the field of wound repair, showcasing its unique regenerative capabilities and extensive application potential. However, it is a challenge for the keratin to efficiently therapy the impaired wound heal...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Springer
2025-01-01
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| Series: | Journal of Materials Science: Materials in Medicine |
| Online Access: | https://doi.org/10.1007/s10856-025-06860-z |
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| author | Yu-mei Wang Tong Xin Hao Deng Jie Chen Shen-lin Tang Li-sheng Liu Xiao-liang Chen |
| author_facet | Yu-mei Wang Tong Xin Hao Deng Jie Chen Shen-lin Tang Li-sheng Liu Xiao-liang Chen |
| author_sort | Yu-mei Wang |
| collection | DOAJ |
| description | Abstract Human hair keratin, a natural protein derived from human hair, has emerged prominently in the field of wound repair, showcasing its unique regenerative capabilities and extensive application potential. However, it is a challenge for the keratin to efficiently therapy the impaired wound healing, such as combined radiation-wound injury. Here, we report a keratin/chitosan (KRT/CS) film for skin repair of chronic wounds in in rats with combined radiation-wound injury. In brief, the KRT/CS film was characterized by scanning electron microscopy (SEM), mechanical property analysis, water absorption, and swelling analysis. A rat model of combined radiation-wound injury was employed to evaluate the therapeutic efficacy of the KRT/CS film. Finally, the systemic biotoxicity of KRT/CS film was assessed through histological analysis. The surface of KRT/CS film was uniform and smooth compared with the KRT film, and the mechanical property, swelling rate and water absorption rate of KRT/CS film were significantly improved, which can meet the application requirements of wound excipient dressing. Furthermore, the combined radiation-wound injury in rats was established that the wound closure rate was achieved 74.46% after 14 days of treatment with KRT/CS film, comparing to the single KRT membrane and commercially available Band-Aids. Histological analysis demonstrated that the amount of angiogenesis and collagen deposition in wounds treated with KRT/CS were significantly improved. These findings demonstrate the KRT/CS film as a promising therapeutic agent for combined radiation-wound injury. Graphical Abstract |
| format | Article |
| id | doaj-art-2ca0ae1e5da34908b266b129ae8d0814 |
| institution | Kabale University |
| issn | 1573-4838 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Springer |
| record_format | Article |
| series | Journal of Materials Science: Materials in Medicine |
| spelling | doaj-art-2ca0ae1e5da34908b266b129ae8d08142025-02-02T12:06:30ZengSpringerJournal of Materials Science: Materials in Medicine1573-48382025-01-0136111110.1007/s10856-025-06860-zKeratin/chitosan film promotes wound healing in rats with combined radiation-wound injuryYu-mei Wang0Tong Xin1Hao Deng2Jie Chen3Shen-lin Tang4Li-sheng Liu5Xiao-liang Chen6Department of Nuclear Medicine, Chongqing University Cancer HospitalDepartment of Nuclear Medicine, Chongqing University Cancer HospitalDepartment of Nuclear Medicine, Chongqing University Cancer HospitalDepartment of Nuclear Medicine, Chongqing University Cancer HospitalDepartment of Nuclear Medicine, Chongqing University Cancer HospitalDepartment of Nuclear Medicine, Chongqing University Cancer HospitalDepartment of Nuclear Medicine, Chongqing University Cancer HospitalAbstract Human hair keratin, a natural protein derived from human hair, has emerged prominently in the field of wound repair, showcasing its unique regenerative capabilities and extensive application potential. However, it is a challenge for the keratin to efficiently therapy the impaired wound healing, such as combined radiation-wound injury. Here, we report a keratin/chitosan (KRT/CS) film for skin repair of chronic wounds in in rats with combined radiation-wound injury. In brief, the KRT/CS film was characterized by scanning electron microscopy (SEM), mechanical property analysis, water absorption, and swelling analysis. A rat model of combined radiation-wound injury was employed to evaluate the therapeutic efficacy of the KRT/CS film. Finally, the systemic biotoxicity of KRT/CS film was assessed through histological analysis. The surface of KRT/CS film was uniform and smooth compared with the KRT film, and the mechanical property, swelling rate and water absorption rate of KRT/CS film were significantly improved, which can meet the application requirements of wound excipient dressing. Furthermore, the combined radiation-wound injury in rats was established that the wound closure rate was achieved 74.46% after 14 days of treatment with KRT/CS film, comparing to the single KRT membrane and commercially available Band-Aids. Histological analysis demonstrated that the amount of angiogenesis and collagen deposition in wounds treated with KRT/CS were significantly improved. These findings demonstrate the KRT/CS film as a promising therapeutic agent for combined radiation-wound injury. Graphical Abstracthttps://doi.org/10.1007/s10856-025-06860-z |
| spellingShingle | Yu-mei Wang Tong Xin Hao Deng Jie Chen Shen-lin Tang Li-sheng Liu Xiao-liang Chen Keratin/chitosan film promotes wound healing in rats with combined radiation-wound injury Journal of Materials Science: Materials in Medicine |
| title | Keratin/chitosan film promotes wound healing in rats with combined radiation-wound injury |
| title_full | Keratin/chitosan film promotes wound healing in rats with combined radiation-wound injury |
| title_fullStr | Keratin/chitosan film promotes wound healing in rats with combined radiation-wound injury |
| title_full_unstemmed | Keratin/chitosan film promotes wound healing in rats with combined radiation-wound injury |
| title_short | Keratin/chitosan film promotes wound healing in rats with combined radiation-wound injury |
| title_sort | keratin chitosan film promotes wound healing in rats with combined radiation wound injury |
| url | https://doi.org/10.1007/s10856-025-06860-z |
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