Regulation of microglial physiology by the microbiota
The mammalian gut contains a large, complex community of microorganisms collectively termed the microbiota. It is increasingly appreciated that gut microbes are closely integrated into mammalian physiology, participating in metabolic symbiosis, promoting immune function and signaling to a wide varie...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | Gut Microbes |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2022.2125739 |
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| _version_ | 1850109056680722432 |
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| author | James Cook Marco Prinz |
| author_facet | James Cook Marco Prinz |
| author_sort | James Cook |
| collection | DOAJ |
| description | The mammalian gut contains a large, complex community of microorganisms collectively termed the microbiota. It is increasingly appreciated that gut microbes are closely integrated into mammalian physiology, participating in metabolic symbiosis, promoting immune function and signaling to a wide variety of distant cells, including the brain, via circulating metabolites. Recent advances indicate that microglia, the brain’s resident immune cells, are influenced by microbial metabolites at all stages of life, under both physiological and pathological conditions. The pathways by which microbiota regulate microglial function are therefore of interest for investigating links between neurological disorders and gut microbiome changes. In this review, we discuss the effects and mechanisms of microbiota-microglia signaling in steady state, as well as evidence for the involvement of this signaling axis in CNS pathologies. |
| format | Article |
| id | doaj-art-2c94e2ddfb644c13a6a21f68eb1ecbe0 |
| institution | OA Journals |
| issn | 1949-0976 1949-0984 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj-art-2c94e2ddfb644c13a6a21f68eb1ecbe02025-08-20T02:38:11ZengTaylor & Francis GroupGut Microbes1949-09761949-09842022-12-0114110.1080/19490976.2022.2125739Regulation of microglial physiology by the microbiotaJames Cook0Marco Prinz1Institute of Neuropathology, Medical Faculty, University of Freiburg, Freiburg, GermanyInstitute of Neuropathology, Medical Faculty, University of Freiburg, Freiburg, GermanyThe mammalian gut contains a large, complex community of microorganisms collectively termed the microbiota. It is increasingly appreciated that gut microbes are closely integrated into mammalian physiology, participating in metabolic symbiosis, promoting immune function and signaling to a wide variety of distant cells, including the brain, via circulating metabolites. Recent advances indicate that microglia, the brain’s resident immune cells, are influenced by microbial metabolites at all stages of life, under both physiological and pathological conditions. The pathways by which microbiota regulate microglial function are therefore of interest for investigating links between neurological disorders and gut microbiome changes. In this review, we discuss the effects and mechanisms of microbiota-microglia signaling in steady state, as well as evidence for the involvement of this signaling axis in CNS pathologies.https://www.tandfonline.com/doi/10.1080/19490976.2022.2125739Microgliadevelopmentmicrobiotaneurological disordersgut-derived metabolitesgut-brain axis |
| spellingShingle | James Cook Marco Prinz Regulation of microglial physiology by the microbiota Gut Microbes Microglia development microbiota neurological disorders gut-derived metabolites gut-brain axis |
| title | Regulation of microglial physiology by the microbiota |
| title_full | Regulation of microglial physiology by the microbiota |
| title_fullStr | Regulation of microglial physiology by the microbiota |
| title_full_unstemmed | Regulation of microglial physiology by the microbiota |
| title_short | Regulation of microglial physiology by the microbiota |
| title_sort | regulation of microglial physiology by the microbiota |
| topic | Microglia development microbiota neurological disorders gut-derived metabolites gut-brain axis |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2022.2125739 |
| work_keys_str_mv | AT jamescook regulationofmicroglialphysiologybythemicrobiota AT marcoprinz regulationofmicroglialphysiologybythemicrobiota |